Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joseph Krasovsky"'
Autor:
Madhav V. Dhodapkar, Mavis Y.H. Lee, Joseph Krasovsky, Barrie R. Cassileth, Simon Yeung, Susanna Cunningham-Rundles, Gary Deng, Ping-Chung Leung, David H. Chang
Publikováno v:
Planta Medica. 75:312-315
Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is l
Autor:
Haiteng Deng, Amitabha Mazumder, Radek Spisek, Govind Ragupathi, Sundar Jagannath, Phillip Matthews, David H. Vesole, David H. Chang, Joseph Krasovsky, Madhav V. Dhodapkar
Publikováno v:
Blood. 112:1308-1316
CD1d-restricted T cells have been implicated in the pathogenesis of several chronic inflammatory states. However, the nature of the specific ligands recognized by these cells in vivo in patients with inflammatory or malignant diseases remains unknown
Autor:
Hani Hassoun, Yoshitaka Ando, Nancy Liu, Aisha Hutchinson, David H. Chang, Maggi Pack, Nobusuke Nishi, Kelly Kirchhoff, Rebecca Annable, Keren Osman, Ralph M. Steinman, Kunihiko Hayashi, Jennifer Shay, Anjli Kukreja, Matthew D. Geller, Madhav V. Dhodapkar, Joseph Krasovsky, John Connolly
Publikováno v:
The Journal of Experimental Medicine
Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that are implicated in the resistance to pathogens and tumors. Earlier attempts to mobilize NKT cells, specifically, in vivo in humans met with limited success. Here, we
Publikováno v:
The Journal of Experimental Medicine
Most approaches targeting the immune system against tumors have focused on patients with established tumors. However, whether the immune system can recognize preneoplastic stages of human cancer is not known. Here we show that patients with preneopla
Autor:
Matthew D. Geller, Joseph Krasovsky, Kavita M. Dhodapkar, Madhav V. Dhodapkar, David H. Chang, Kanako Shimizu, Shin-ichiro Fujii
Publikováno v:
The Journal of Experimental Medicine
We studied the function of antitumor T and natural killer T (NKT) cells from the blood and tumor bed in 23 patients with premalignant gammopathy, nonprogressive myeloma, or progressive multiple myeloma. We show that antitumor killer T cells can be de
Publikováno v:
The Journal of Experimental Medicine
Immunostimulatory properties of dendritic cells (DCs) are linked to their maturation state. Injection of mature DCs rapidly enhances antigen-specific CD4+ and CD8+ T cell immunity in humans. Here we describe the immune response to a single injection
Publikováno v:
Journal of Clinical Investigation. 105:R9-R14
We have recently shown that a single injection of mature, antigen-pulsed, human dendritic cells (DCs) rapidly elicits CD4+ and CD8+ T-cell immunity in vivo. The DCs were pulsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxo
Autor:
M V Dhodapkar, H Desai, Nina Bhardwaj, Vincenzo Cerundolo, P R Dunbar, Mark Sapp, Joseph Krasovsky, Sean M. Donahoe, Ralph M. Steinman, Douglas F. Nixon, C Fossella
Publikováno v:
Scopus-Elsevier
Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously with a control injection of autologous monocyte-de
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(20)
Most untreated cancer patients develop progressive tumors. We tested the capacity of T lymphocytes from patients with clinically progressive, multiple myeloma to develop killer function against fresh autologous tumor. In this malignancy, it is feasib
Publikováno v:
The Journal of Experimental Medicine
The mechanism of antitumor effect of monoclonal antibodies (mAbs) is not fully understood. Here we show that coating myeloma cells with anti–syndecan-1 antibody promotes cross-presentation of cellular antigens by dendritic cells (DCs) to autologous