Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joseph K. Wichmann"'
Publikováno v:
Epilepsia. 34:367-371
Summary: The anticonvulsant effects of felbamate (FBM) alone or in combination with phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), or phenobarbital (PB) were investigated against maximal electroshock (MES) seizures in mice. Nonprotective dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3ce5aed7ecc2c6ab886748b59000b7
https://doi.org/10.1111/j.1528-1157.1993.tb02423.x
https://doi.org/10.1111/j.1528-1157.1993.tb02423.x
Publikováno v:
Stroke. 27(7)
Background and Purpose Felbamate, a novel anticonvulsant that binds to the glycine site of the N -methyl- d -aspartate receptor, has been shown to have neuroprotective properties in vitro and in vivo. In a rat pup model of hypoxia-ischemia, felbamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2687c3fd8dee25e7b1202897de89c5
https://pubmed.ncbi.nlm.nih.gov/8685935
https://pubmed.ncbi.nlm.nih.gov/8685935
Publikováno v:
Proceedings of the National Academy of Sciences. 77:6411-6414
Labeled 25-hydroxyvitamin D3-26,23-lactone was isolated from the serum of vitamin D-repleted rats given [3 alpha-3H]-25-hydroxyvitamin D324 hr prior to sacrifice. The metabolite was identified by cochromatography with the authentic lactone on straigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35330f399ddbe9d261138f92bfc72179
https://doi.org/10.1073/pnas.77.11.6411
https://doi.org/10.1073/pnas.77.11.6411
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 494:347-353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0295f0ba5f0e23952b4092943034cc
https://doi.org/10.1016/s0378-4347(00)82687-0
https://doi.org/10.1016/s0378-4347(00)82687-0
Autor:
Nobuo Ikekawa, Yoko Tanaka, T. Taguchi, H.F. De Luca, Joseph K. Wichmann, D.N. Pahuja, Yoshiro Kobayashi
Publikováno v:
Archives of Biochemistry and Biophysics. 218:134-141
Vitamin D-deficient rats given 25-hydroxy-26,26,26,27,27,27-hexafluorovitamin D 3 have no detectable 24,25-dihydroxyvitamin D 3 , 1,25-dihydroxyvitamin D 3 , 25,26-dihydroxyvitamin D 3 , or 25-hydroxyvitamin D 3 -26,23-lactone in their blood while th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3473cf8d46d60db8cd1ccc25ef12ae81
https://doi.org/10.1016/0003-9861(82)90328-9
https://doi.org/10.1016/0003-9861(82)90328-9
Autor:
Heinrich K. Schnoes, Hector F. DeLuca, Richard M. Shepard, Joseph K. Wichmann, Neal A. Jorgensen, Ronald L. Horst
Publikováno v:
Biochemistry. 18:4775-4780
A major vitamin D metabolite was isolated in pure form from the blood plasma of chicks either maintenance levels or large doses of vitamin D3. The isolation involved methanol-chloroform extraction and five column chromatographic procedures. The metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b381147b5cb38bf767be9dc2284056c5
https://doi.org/10.1021/bi00589a002
https://doi.org/10.1021/bi00589a002
Publikováno v:
Tetrahedron Letters. 21:4667-4670
All four possible C-23 and C-25 stereoisomers of the title compound have been synthesized. One of these isomers is identical to the natural product.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9056ca105e3584bbc6e0a731d337300
https://doi.org/10.1016/0040-4039(80)88089-0
https://doi.org/10.1016/0040-4039(80)88089-0
Publikováno v:
Archives of biochemistry and biophysics. 225(2)
To evaluate possible functional roles for 24,25-dihydroxyvitamin D3, 24,24-difluoro-25-hydroxyvitamin D3 has been synthesized and shown to be equally as active as 25-hydroxyvitamin D3 in all known functions of vitamin D. The use of the difluoro compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a216c2ea42c79c744510815bbba43e05
https://pubmed.ncbi.nlm.nih.gov/6688712
https://pubmed.ncbi.nlm.nih.gov/6688712
Publikováno v:
Biochemistry. 20(13)
Vitamin D supplemented rats produce a metabolite of 25-hydroxy[3 alpha-3H]vitamin D3 that is easily separated from known metabolites by using high-performance liquid chromatography. The production of this metabolite in vivo as well as 1,25-dihydroxyv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5a3ce046f3225254f69e511ad0e1b1
https://pubmed.ncbi.nlm.nih.gov/6268149
https://pubmed.ncbi.nlm.nih.gov/6268149
Autor:
Robert U. Simpson, Heinrich K. Schnoes, Hector F. DeLuca, Herbert E. Paaren, Joseph K. Wichmann
Publikováno v:
Archives of biochemistry and biophysics. 230(1)
A primary confluent culture of epithelial cells from rat kidney has been developed. These cells possess a 3.2-3.4 S high-affinity, low-capacity binding protein for 1,25-dihydroxyvitamin D3. They metabolize 25-hydroxyvitamin D3 to at least five metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccde64477af428326f31b628c247f955
https://pubmed.ncbi.nlm.nih.gov/6712232
https://pubmed.ncbi.nlm.nih.gov/6712232