Výsledky vyhledávání - "Joseph K. Mwatha"

Akademický článek

Locating irregularly shaped clusters of infection intensity

Autor: Niko Yiannakoulias, Shona Wilson, H. Curtis Kariuki, Joseph K. Mwatha, John H. Ouma, Eric Muchiri, Gachuhi Kimani, Birgitte J. Vennervald, David W. Dunne

Publikováno v: Geospatial Health, Vol 4, Iss 2, Pp 191-200 (2010)

Patterns of disease may take on irregular geographic shapes, especially when features of the physical environment influence risk. Identifying these patterns can be important for planning, and also identifying new environmental or social factors assoc

Externí odkaz: https://doaj.org/article/0e41c35abb734e4881e4acdb7a5a14dd

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CIRCULATORY CYTOKINES AND HEMATOLOGICAL PROFILES: POSSIBLE BIOMARKERS OF HIV/AIDS DISEASE PROGRESSION

Autor: Joseph K. Mwatha, Jane N. Mugwe, Michael M. Gicheru

Publikováno v: LIFE: International Journal of Health and Life-Sciences. 5:105-118

Introduction: This study sought to identify circulatory cytokines and hematological profiles measureable in blood plasma in newly diagnosed HIV patients as possible biomarkers that could predict the progression of HIV and AIDS disease in the course o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51992169e64b40ec859b3bed27b18505
https://doi.org/10.20319/lijhls.2019.51.105118

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Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren

Autor: Kimani Gachuhi, Joseph K. Mwatha, Shona Wilson, Jovita M. Castelino, Christopher P. Wild, David W. Dunne, Yun Yun Gong, Michael N. Routledge

Publikováno v: Molecular Nutrition & Food Research. 59:574-581

This study explores the relationship between aflatoxin and the insulin-like growth factor (IGF) axis and its potential effect on child growth.One hundred and ninety-nine Kenyan schoolchildren were studied for aflatoxin-albumin adduct (AF-alb), IGF1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f6ec3aac07ec34d30a0d4737c5e555
https://doi.org/10.1002/mnfr.201300619

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Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis

Autor: Shona Wilson, Eric M. Muchiri, Joseph K. Mwatha, Mark Booth, John H. Ouma, Gachuhi Kimani, Birgitte J. Vennervald, Frances M. Jones, H. C. Kariuki, David W. Dunne

Publikováno v: Parasite Immunology

In sub-Saharan Africa, chronic hepatosplenomegaly, with palpable firm/hard organ consistency, is common, particularly among school-aged children. This morbidity can be caused by long-term exposure to malaria, or by Schistosoma mansoni, and it is exac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcb43582c335c7ec0c7d8ed2d871a87
http://europepmc.org/articles/PMC2680340

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Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection

Autor: Joseph K. Mwatha, Mark Booth, David W. Dunne, H. Curtis Kariuki, Eric M. Muchiri, Birgitte J. Vennervald, John H. Ouma, Hilda Kadzo, Gachuhi Kimani, Clifford Amaganga, Edmund Ireri, Shona Wilson

Publikováno v: Tropical Medicine & International Health. 12:1442-1449

OBJECTIVES Chronic exposure to malaria exacerbates Schistosoma mansoni-associated hepatosplenomegaly in school-aged children. However, residual hepatosplenomegaly after treatment of S. mansoni with concurrent mollusciciding suggests malaria could be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04585da724543622f549cc1d20d7632c
https://doi.org/10.1111/j.1365-3156.2007.01950.x

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Increased Human IgE Induced by Killing Schistosoma mansoni In Vivo Is Associated with Pretreatment Th2 Cytokine Responsiveness to Worm Antigens

Autor: Joseph K. Mwatha, Sarah Joseph, David W. Dunne, H. Curtis Kariuki, John H. Ouma, Gachuhi Kimani, Rowena McBeath, Anthony J. C. Fulford, Klaudia Walter, Narcis B. Kabatereine, Frances M. Jones, Birgitte J. Vennervald

Publikováno v: The Journal of Immunology. 177:5490-5498

In schistosomiasis endemic areas, children are very susceptible to postchemotherapy reinfection, whereas adults are relatively resistant. Different studies have reported that schistosome-specific IL-4 and IL-5 responses, or posttreatment worm-IgE lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb75fc6f1d02b19f8b561989d8a79842
https://doi.org/10.4049/jimmunol.177.8.5490

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Eosinophil Activity inSchistosoma mansoniInfections In Vivo and In Vitro in Relation to Plasma Cytokine Profile Pre- and Posttreatment with Praziquantel

Autor: Birgitte J. Vennervald, Claus M. Reimert, Mark Booth, David W. Dunne, Gachuhi Kimani, Joseph K. Mwatha, Frances M. Jones, Colin M. Fitzsimmons, Karl F. Hoffmann, Sarah Joseph, Narcis B. Kabatereine

Publikováno v: Clinical and Vaccine Immunology. 13:584-593

Eosinophil activity in vivo and in vitro was studied in relation to infection intensities and plasma cytokine profiles of 51Schistosoma mansoni-infected Ugandan fishermen before treatment and 24 h and 3 weeks posttreatment. Blood eosinophil numbers s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b920770c2b595cd1a427e14f38b438
https://doi.org/10.1128/cvi.13.5.584-593.2006

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Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni

Autor: Hilda Kadzo, H. Curtis Kariuki, Gachuhi Kimani, LeeCarol Kenty, John H. Ouma, Edmund Ireri, Joseph K. Mwatha, Birgitte J. Vennervald, Anthony E. Butterworth, Mark Booth, David W. Dunne, Clifford Amaganga

Publikováno v: Transactions of the Royal Society of Tropical Medicine and Hygiene. 99:150-160

Evaluating regression of morbidity associated with parasitic infections is an important component of community-based control programmes. We performed an intervention against Schistosoma mansoni infection, focusing on hepatosplenomegaly in the absence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0aea0ef06c3d87aaf76267b7784baf
https://doi.org/10.1016/j.trstmh.2004.06.009

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Increases in Human T Helper 2 Cytokine Responses toSchistosoma mansoniWorm and Worm‐Tegument Antigens Are Induced by Treatment with Praziquantel

Autor: Gachuhi Kimani, John H. Ouma, Frances M. Jones, Narcis B. Kabatereine, Anthony J. C. Fulford, Timothy Kamau, Edridah M. Tukahebwa, David W. Dunne, Francis Kazibwe, Joseph K. Mwatha, H. C. Kariuki, Birgitte J. Vennervald, Klaudia Walter, Sarah Joseph

Publikováno v: The Journal of Infectious Diseases. 190:835-842

Levels of Schistosoma mansoni-induced interleukin (IL)-4 and IL-5 and posttreatment levels of immunoglobulin E recognizing the parasite's tegument (Teg) correlate with human resistance to subsequent reinfection after treatment. We measured changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad09c26a243092e42bb2635e3f22b116
https://doi.org/10.1086/422604

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Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence

Autor: Narcis B. Kabatereine, Eric M. Muchiri, David W. Dunne, B. J. Vennervald, Gachuhi Kimani, Mark Booth, Joseph K. Mwatha, John H. Ouma, Curtis H. Kariuki, Hilda Kadzo, Edmund Ireri, Francis Kazibwe

Publikováno v: Transactions of the Royal Society of Tropical Medicine and Hygiene. 98:125-136

Peri-portal fibrosis can be a serious sequelae of Schistosoma mansoni infection. Age or duration of exposure have been identified as important risk factors, but their relative importance cannot be easily separated. Here, we have compared two cohorts,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea85fbd603594421013b0e544dc8391c
https://doi.org/10.1016/s0035-9203(03)00018-x

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