Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joseph K. Angleson"'
Autor:
Navdeep Sandhu, Joseph K. Angleson, Robert M. Dores, Kristin Schmid, Mathilakath M. Vijayan, Liang Liang
Publikováno v:
General and Comparative Endocrinology. 210:145-151
Functional expression of the rainbow trout (rt) melanocortin-2 receptor (MC2R) in CHO cells requires co-expression with a teleost melanocortin-2 receptor accessory protein (MRAP) such as zebrafish (zf) MRAP. Transiently transfected rtMC2R/zfMRAP1 CHO
Publikováno v:
General and Comparative Endocrinology. 188:75-84
The tetrapods are a diverse assemblage of vertebrates, and that diversity is reflected in the sequences of tetrapod melanocortin-2 receptors (MC2Rs). In this review, the features common to human (mammal), Gallus gallus (bird), Anolis carolinensis (re
Publikováno v:
General and Comparative Endocrinology. 181:4-9
There is general agreement that the presence of five melanocortin receptor genes in tetrapods is the result of two genome duplications that occurred prior to the emergence of the gnathostomes, and at least one local gene duplication that occurred ear
Publikováno v:
General and Comparative Endocrinology. 181:203-210
When considering the interactions between the melanocortin peptides (i.e., ACTH, α-MSH, β-MSH, γ-MSH) and the melanocortin receptors (i.e., MC1R, MC2R, MC3R, MC4R, MC5R), it appears that the structure/function relationship between ACTH and MC2R is
Publikováno v:
Endocrinology. 153:4757-4765
Phylogenetic analyses indicate that the genome of the cartilaginous fish, Callorhynchus milii (elephant shark), encodes a melanocortin-2 receptor (MC2R) ortholog. Expression of the elephant shark mc2r cDNA in Chinese hamster ovary (CHO) cells reveale
Autor:
Kristopher Veo, Robert M. Dores, Emily Moser, Liang Liang, Christina Reinick, Joseph K. Angleson
Publikováno v:
General and Comparative Endocrinology. 172:3-9
The melanocortin 2 receptor (MC2R) is unique in terms of ligand selectivity and in vitro expression in mammalian cell lines as compared to the other four mammalian MCRs. It is well established that ACTH is the only melanocortin ligand that can activa
Autor:
John F. Hutton, Erin Domke, Tobias R. Zahn, Margaret MacMorris, Cindi L. Schwartz, Joseph K. Angleson, John C. Hutton
Publikováno v:
Traffic. 5:544-559
We have developed a model system in Caenorhabditis elegans to perform genetic and molecular analysis of peptidergic neurotransmission using green fluorescent protein (GFP)-tagged IDA-1. IDA-1 represents the nematode ortholog of the transmembrane prot
Autor:
Joseph K. Angleson, Larissa Ikenouye
Publikováno v:
The FASEB Journal. 28
Hormone secretion form anterior pituitary cells is known to be regulated by G protein coupled receptors (GPCRs) that regulate intracellular cAMP. The objective of this study was to determine mechan...
Publikováno v:
The Journal of Cell Biology
We used fluorescence imaging of individual exocytic events together with electron microscopy to study the regulation of dense core granule-to-plasma membrane fusion and granule-to-granule fusion events that occur during secretion from rat pituitary l
Publikováno v:
Nature Neuroscience. 2:440-446
Using FM1-43 fluorescence, we have optically detected single exocytic and endocytic events in rat pituitary lactotrophs. About fifty discrete fluorescent spots abruptly appear around the entire surface of a cell bathed in FM1-43 and high-potassium sa