Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Joseph K Belanoff"'
Autor:
Jacqueline L Beaudry, Emily C Dunford, Trevor Teich, Dessi Zaharieva, Hazel Hunt, Joseph K Belanoff, Michael C Riddell
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91248 (2014)
The blockade of glucocorticoid (GC) action through antagonism of the glucocorticoid receptor II (GRII) has been used to minimize the undesirable effects of chronically elevated GC levels. Mifepristone (RU486) is known to competitively block GRII acti
Externí odkaz:
https://doaj.org/article/dcb4d5428faa4c738a0b2c6366875371
Publikováno v:
AACE Clinical Case Reports, Vol 8, Iss 1, Pp 25-29 (2022)
AACE Clinical Case Reports
AACE Clinical Case Reports
Background Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western industrialized countries and may progress to liver injury. Cortisol is thought to play a role in the pathogenesis of NAFLD, and cortisol modulation has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc517107867fd78c2e977ade620ba945
http://www.sciencedirect.com/science/article/pii/S2376060521000869
http://www.sciencedirect.com/science/article/pii/S2376060521000869
Publikováno v:
Journal of the Endocrine Society. 6:A496-A496
Background Hypercortisolism is a recognized cause of non-alcoholic fatty liver disease (NAFLD). Mifepristone (Korlym®, Corcept Therapeutics), a glucocorticoid receptor (GR) antagonist, is FDA-approved for the treatment of hyperglycemia in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f38e0a0030c7b8790bd8ffd3f8dab9
https://doi.org/10.1210/jendso/bvac150.1031
https://doi.org/10.1210/jendso/bvac150.1031
Autor:
Maria Claudia Gonzalez Deniselle, Joseph K. Belanoff, Alejandro F. De Nicola, Paulina Roig, Maria Meyer, Hazel Hunt, Laura Garay, Analia Lima, E. Ronald de Kloet, Maria Sol Kruse
Publikováno v:
Brain Research, 1727. ELSEVIER
The Wobbler mouse spinal cord shows vacuolated motoneurons, glial reaction, inflammation and abnormal glutamatergic parameters. Wobblers also show deficits of motor performance. These conditions resemble amyotrophic lateral sclerosis (ALS). Wobbler m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207a33dca501fbbb680f620419804a32
http://hdl.handle.net/1887/3181541
http://hdl.handle.net/1887/3181541
Autor:
Agustina Lara, Maria Meyer, Hazel Hunt, Alejandro F. De Nicola, E. Ronald de Kloet, Maria Claudia Gonzalez Deniselle, Joseph K. Belanoff
Publikováno v:
Neuroscience. 384:384-396
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5f06a11d7937902d9f6e6a74604426
https://doi.org/10.1016/j.neuroscience.2018.05.042
https://doi.org/10.1016/j.neuroscience.2018.05.042
Autor:
Joseph K. Belanoff, Thaddeus Block, Harvey Kushner, Ned H. Kalin, Alan F. Schatzberg, Craig Nelson
Publikováno v:
Biological Psychiatry. 84:46-54
Patients with psychotic depression exhibit elevated cortisol levels. Competitively antagonizing cortisol at the glucocorticoid receptor with mifepristone demonstrated therapeutic benefit in early studies of patients with psychotic depression. We pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b636b84dceea5f086f6f8636a32c004
https://doi.org/10.1016/j.biopsych.2018.01.008
https://doi.org/10.1016/j.biopsych.2018.01.008
Autor:
Tomoko Asagami, Joseph K. Belanoff, Junya Azuma, Christine M. Blasey, Robin D. Clark, Philip S. Tsao
Publikováno v:
Journal of Nutrition and Metabolism, Vol 2011 (2011)
Previous research has shown that mifepristone can prevent and reverse weight gain in animals and human subjects taking antipsychotic medications. This proof-of-concept study tested whether a more potent and selective glucocorticoid receptor antagonis
Externí odkaz:
https://doaj.org/article/d6bb35cb66ce4922b62ec2b2fdba9564
Autor:
Joseph K. Belanoff, Hazel Hunt, Pui Leung, Dan Combs, Alyson Connor, Kirsteen Donaldson, Vanessa Zann, Mark Strem, Suzanne Sweet
Publikováno v:
Clinical Pharmacology in Drug Development
CORT125134 is an orally active, high‐affinity, selective antagonist of the glucocorticoid receptor that is being developed for indications that may benefit from the modulation of cortisol activity. This first‐in‐human study was conducted to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468fb3c2060903268a1ed4a9ad8777c4
http://europepmc.org/articles/PMC5947602
http://europepmc.org/articles/PMC5947602
Autor:
Ned H. Kalin, Alan F. Schatzberg, Thaddeus Block, Joseph K. Belanoff, Georgios Petrides, Harvey Kushner
Publikováno v:
Journal of Clinical Psychopharmacology
Supplemental digital content is available in the text.
Background Psychotic depression has no Food and Drug Administration–approved treatment. Patients demonstrate significant dysregulation of the hypothalamic-pituitary-adrenal axis providing
Background Psychotic depression has no Food and Drug Administration–approved treatment. Patients demonstrate significant dysregulation of the hypothalamic-pituitary-adrenal axis providing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b75acc7418e8e7d1c87b348c8b6870
https://doi.org/10.1097/jcp.0000000000000744
https://doi.org/10.1097/jcp.0000000000000744
Autor:
John Unitt, Hazel Hunt, Jennifer Thomas, Emily Eaton, Naomi Barton, Iain Walters, Joseph K. Belanoff, Timothy Phillips, Benoit Gourdet, Denise Swift
Publikováno v:
Journal of Medicinal Chemistry. 60:3405-3421
The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing’s syndrome. While this drug is highly effective, lack of selectivity for GR leads to unwanted si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14042718beb90b78ce455d562051169
https://doi.org/10.1021/acs.jmedchem.7b00162
https://doi.org/10.1021/acs.jmedchem.7b00162