Výsledky vyhledávání - "Joseph K, Welply"

Progenipoietins

Autor: Philip R. Streeter, William F. Hood, Tammy L. Thurman, John P. McKearn, Joseph K. Welply, Larry E Kahn, Woulfe Susan L, Nancy I. Minster, Joseph B. Monahan, Lillian E Vickery

Publikováno v: Experimental Hematology. 29:41-50

Objective The progenipoietins, a class of engineered proteins containing both fetal liver tyrosine kinase-3 and granulocyte colony-stimulating factor receptor agonist activities, were functionally characterized in vitro and in vivo. Materials and Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90635cd6e1fbecfb24c032d0c2be6da
https://doi.org/10.1016/s0301-472x(00)00616-0

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Use of combinatorial mutagenesis to select for multiply substituted human interleukin-3 variants with improved pharmacologic properties

Autor: Jeng-Jong Shieh, Peter O. Olins, Maire Helena Caparon, William F. Hood, Kumnan Paik, Ann M. Donnelly, Bauer Christopher S, John P. McKearn, Sarah R. Braford, Polazzi Joseph O, John W. Thomas, Jon A. Klover, Alan Michael Easton, David L. Zeng, Mark Allen Abrams, Joseph K. Welply, Barbara K. Klein

Publikováno v: Experimental Hematology. 27:1746-1756

A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid substitutions clustered within four linear, nonoverlapping regions of the polypeptide. The va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4c1a8be21dd8999107c60b154356b0
https://doi.org/10.1016/s0301-472x(99)00118-6

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Small retro-inverso peptides recognize mhc class ii ula dr(a, j31*0401)

Autor: Gunnar J. Hanson, Susan C. Howard, Michelle L. Zacheis, Christine P. Bono, Joseph K. Welply, Jennifer L. Vuletich, Louis J. Bedell, Neena L. Summers, Benjamin D. Schwartz, Susan L. Woulfe

Publikováno v: Protein & Peptide Letters. 4:63-68

Abstract: We have synthesized a series of retro-inverso D-peptide analogues and a peptoid analog that mimic potent seven residue L-peptide ligands for DR(a. Pl*0401). The L-peptide ligands compete against binding of a 13 residue biotinylated ligand,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4d5f3c4dae482c55fa4d7938953ea4b
https://doi.org/10.2174/092986650401221012144617

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A peptide isolated by phage display binds to ICAM-1 and inhibits binding to LFA-1

Autor: Gerald F. Casperson, Pamela A. De Ciechi, Lyle E. Pegg, Catherine S. Devine, Marshall L. Michener, Debra M. Meyer, Christina N. Steininger, Joseph K. Welply, Maire Helena Caparon, Susan C. Howard

Publikováno v: Proteins: Structure, Function, and Genetics. 26:262-270

A mixed phage library containing random peptides from four to eight residues in length flanked by cysteine residues was screened using a recombinant soluble, form of human ICAM-1, which included residues 1-453, (ICAM-1(1-453)). Phage bound to immobil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04a510161eb8ea5355d8334638792a76
https://doi.org/10.1002/(sici)1097-0134(199611)26:3<262::aid-prot3>3.0.co

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Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5

Autor: Susan L. Woulfe, Michelle L. Zacheis, Jennifer L. Vuletich, Louis J. Bedell, Christine P. Bono, Susan C. Howard, Joseph K. Welply, Gunnar J. Hanson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1931-1936

High potency synthetic ligands were designed for rheumatoid arthritis linked Class II MHC, DR4 Dw4. The design strategy utilized isosteric replacements at the p1 and p7 positions and conformational restriction with imino acids pipecolic acid (Pec) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::829a6226851b82e92bf820b086ea583f
https://doi.org/10.1016/0960-894x(96)00348-4

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Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation

Autor: Tucker Collins, Jon J. Schmuke, Songmei Yin, James H. Williams, Kaizhi Guo, Eunhee S. Yi, Jeffery L. Keene, Joseph K. Welply, Daniel G. Remick, Thomas R. Ulich, Susan C. Howard, Christina N. Steininger

Publikováno v: Inflammation. 18:389-398

E-selectin is an inducible endothelial adhesion molecule that binds neutrophils. E-selectin mRNA is not constitutively detectable in the lungs of rats. Intratracheal injection of LPS induces pulmonary E-selectin mRNA expression at 2–4 h. Intratrach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642b76cd542a45d3d15e72c711203ca4
https://doi.org/10.1007/bf01534436

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Identification and oligosaccharide structure analysis of rhodopsin glycoforms containing galactose and sialic acid

Autor: Gary W. Lange, Paul J. O'Brien, Joseph K. Welply, Richard Florman, Howard R. Morris, Steven J. Fliesler, Andrew J. Reason, Kevin L. Duffin, Anne Dell

Publikováno v: Glycobiology. 3:365-380

The N-linked oligosaccharides of frog (Rana pipiens) rhodopsin were analysed by sequential exoglycosidase digestion and gel filtration chromatography, following reductive tritiation. In addition, selected tryptic glycopeptides obtained from frog reti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c33ed8af59dcf24556846eeffa7a91
https://doi.org/10.1093/glycob/3.4.365

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The glycoprotease of Pasteurella haemolytica A1 eliminates binding of myeloid cells to P-selectin but not to E-selectin

Autor: Christopher A. Eddy, Joseph K. Welply, Christina N. Steininger, Richard M. Leimgruber, Alan Mellors

Publikováno v: Biochemical and Biophysical Research Communications. 188:760-766

HL-60 cells and neutrophils treated with the glycoprotease from Pasteurella haemolytica A1, an enzyme which is specific for O-sialoglycoproteins, were found to be incapable of binding P-selectin but still bound E-selectin. Comparative analysis of [35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91146924e4e84f64440f2baeb1252540
https://doi.org/10.1016/0006-291x(92)91121-6

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Mammalian cell production and purification of progenipoietin, a dual-agonist chimaeric haematopoietic growth factor

Autor: Karl J. Mathis, William D. Joy, Joseph K. Welply, David C. Wood, Lyle E. Pegg, John C. Minnerly

Publikováno v: Biotechnology and applied biochemistry. 37(Pt 1)

One member of the progenipoietin (ProGP) family of engineered proteins, ProGP-2, is a chimaeric dual cytokine receptor agonist, expressed in mammalian cells, that stimulates both human fetal liver tyrosine kinase-3 (Flt3) and the granulocyte-colony-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ff1d2a8439370905d48a3950b947e3
https://pubmed.ncbi.nlm.nih.gov/12578549

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