Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joseph J. Zeppa"'
Publikováno v:
Toxins, Vol 7, Iss 5, Pp 1821-1836 (2015)
Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system activation. Staphylococcus aureus possesses a large repertoire of
Externí odkaz:
https://doaj.org/article/ff16c14f684c4bc58eeda89fb0d7a522
Autor:
Yiran E. Liu, Patricia A. Darrah, Joseph J. Zeppa, Megha Kamath, Farida Laboune, Daniel C. Douek, Pauline Maiello, Mario Roederer, JoAnne L. Flynn, Robert A. Seder, Purvesh Khatri
SUMMARYBlood-based correlates of vaccine-induced protection against tuberculosis (TB) are urgently needed. We analyzed the blood transcriptome of rhesus macaques immunized with varying doses of intravenous (IV) BCG followed byMycobacterium tuberculos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0fb38c5ba51a76c26f5e13222bbfa9
https://doi.org/10.1101/2022.11.14.516343
https://doi.org/10.1101/2022.11.14.516343
Autor:
JoAnne L. Flynn, Patricia A. Darrah, Phillip A. Swanson, Nicole L. Grant, Pauline Maiello, Chelsea M Causgrove, Travis K. Hughes, Danilo R. Casimiro, Megha Kamath, Joseph J. Zeppa, Edwin Klein, Supriya Pokkali, Alexander G. White, Mario Roederer, Philana Ling Lin, Joshua A Hackney, Aurelio Bonavia, Charles A. Scanga, Marc H. Wadsworth, Alex K. Shalek, Robert A. Seder, Dominick Laddy, Mark Rodgers
Publikováno v:
Nature. 577:95-102
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guerin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause o
Autor:
Patricia A. Darrah, Joseph J. Zeppa, Chuangqi Wang, Edward B. Irvine, Allison N. Bucsan, Mark A. Rodgers, Supriya Pokkali, Joshua A. Hackney, Megha Kamath, Alexander G. White, H. Jacob Borish, L. James Frye, Jaime Tomko, Kara Kracinovsky, Philana L. Lin, Edwin Klein, Charles A. Scanga, Galit Alter, Sarah M. Fortune, Douglas A. Lauffenburger, JoAnne L. Flynn, Robert A. Seder, Pauline Maiello, Mario Roederer
Publikováno v:
SSRN Electronic Journal.
The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
Autor:
Andrew W Simonson, Allison N Bucsan, Joseph J Zeppa, Caylin G Winchell, Amy J Myers, Matthew Sutton, Cassaundra L Ameel, Patricia A Darrah, Mario Roederer, Robert A Seder, JoAnne L Flynn
Publikováno v:
The Journal of Immunology. 208:181.11-181.11
Background We previously demonstrated in non-human primates (NHP) that intravenous (IV) administration of BCG induces substantial T cell responses and often sterilizing immunity against Mycobacterium tuberculosis (Mtb) infection. Here, we investigate
Autor:
Katherine J Kasper, Joseph J Zeppa, Adrienne T Wakabayashi, Stacey X Xu, Delfina M Mazzuca, Ian Welch, Miren L Baroja, Malak Kotb, Ewa Cairns, P Patrick Cleary, S M Mansour Haeryfar, John K McCormick
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004155 (2014)
Establishing the genetic determinants of niche adaptation by microbial pathogens to specific hosts is important for the management and control of infectious disease. Streptococcus pyogenes is a globally prominent human-specific bacterial pathogen tha
Externí odkaz:
https://doaj.org/article/ac1b66d7d94a4ec6aeab4da369e8e0a4
Autor:
Ivor Mohorovic, Delfina M. Mazzuca, S. M. Mansour Haeryfar, Katherine J. Kasper, John K. McCormick, Joseph J. Zeppa
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10226-10231
The globally prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory proteins known as superantigens (SAgs), which engage lateral surfaces of major histocompatibility class II molecules and T-cell receptor (TCR) β-chain variable d
Autor:
Zhigang Li, Geoffrey N. Hendy, Joaquín Madrenas, Mark A. Hancock, Joseph J. Zeppa, Terence M. Doherty, John K. McCormick
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(4)
Canonical Ag-dependent TCR signaling relies on activation of the src-family tyrosine kinase LCK. However, staphylococcal superantigens can trigger TCR signaling by activating an alternative pathway that is independent of LCK and utilizes a Gα11-cont
Autor:
Peter A. Szabo, S. M. Mansour Haeryfar, Kevin J. Gilmore, John K. McCormick, Joseph J. Zeppa, Stacey X. Xu, Miren L. Baroja
Publikováno v:
Infection and Immunity. 82:3588-3598
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can induce a dysregulated cytokine storm as a component of what is known as tox
Autor:
Christine A. Herfst, Brent D. Armstrong, John K. McCormick, Joseph J. Zeppa, Adrienne T. Wakabayashi, Nicholas C. Tonial
Publikováno v:
Scientific Reports
Streptococcus pyogenes is a globally prominent bacterial pathogen that exhibits strict tropism for the human host, yet bacterial factors responsible for the ability of S. pyogenes to compete within this limited biological niche are not well understoo