Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joseph J. Porter"'
Autor:
Joseph J. Porter, John D. Lueck
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102197- (2024)
Externí odkaz:
https://doaj.org/article/0f7fec57b94c487b87097dde796dec24
Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 685-701 (2022)
Nonsense mutations or premature termination codons (PTCs) comprise ∼11% of all genetic lesions, which result in over 7,000 distinct genetic diseases. Due to their outsized impact on human health, considerable effort has been made to find therapies
Externí odkaz:
https://doaj.org/article/0445ef3dbb6b47ffb9ec0cde44256465
Autor:
Breland G. Oscar, Liangdong Zhu, Hayati Wolfendeen, Nikita D. Rozanov, Alvin Chang, Kenneth T. Stout, Jason W. Sandwisch, Joseph J. Porter, Ryan A. Mehl, Chong Fang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Tracking the structural dynamics of fluorescent protein chromophores holds the key to unlocking the fluorescence mechanisms in real time and enabling rational design principles of these powerful and versatile bioimaging probes. By combining recent ch
Externí odkaz:
https://doaj.org/article/d82acd3fb69644c785160f4d74131a09
Publikováno v:
J Biol Chem
Production of reactive oxygen species caused by dysregulated endothelial nitric-oxide synthase (eNOS) activity is linked to vascular dysfunction. eNOS is a major target protein of the primary calcium-sensing protein calmodulin. Calmodulin is often mo
Efficient Suppression of Endogenous CFTR Nonsense Mutations Using Anticodon Engineered Transfer RNAs
Nonsense mutations or premature termination codons (PTCs) comprise ∼11% of all genetic lesions, which result in over 7,000 distinct genetic diseases. Due to their outsized impact on human health, considerable effort has been made to find therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0204c91037e8320260250825b8b43bf
https://doi.org/10.1101/2021.10.09.463783
https://doi.org/10.1101/2021.10.09.463783
Publikováno v:
Wiley Interdisciplinary Reviews. RNA
Nonsense mutations change an amino acid codon to a premature termination codon (PTC) generally through a single‐nucleotide substitution. The generation of a PTC results in a defective truncated protein and often in severe forms of disease. Because
Autor:
Xiaodong Gu, Richard B. Cooley, Stanley L. Hazen, Joseph J. Porter, Taylor S. Willi, Joseph A. DiDonato, Ryan A. Mehl, Rachel L. Henson, Hyo Sang Jang
Publikováno v:
ACS Chem Biol
Post-translational modifications (PTMs) of protein tyrosine (Tyr) residues can serve as a molecular fingerprint of exposure to distinct oxidative pathways and are observed in abnormally high abundance in the majority of human inflammatory pathologies
Autor:
Ryan A. Mehl, Joseph J. Porter
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Posttranslational modifications resulting from oxidation of proteins (Ox-PTMs) are present intracellularly under conditions of oxidative stress as well as basal conditions. In the past, these modifications were thought to be generic protein damage, b
Publikováno v:
Protein Science. 27:573-577
Carbonic anhydrase is an enzyme of interest for many biotechnological developments including carbon sequestration. These applications often require harsh conditions, so there is a need for the development of thermostable variants. One of the most the
Publikováno v:
The Journal of Physical Chemistry A. 121:6671-6678
We report doping of green fluorescent protein from an electrospray ionization (ESI) source into superfluid helium droplets. From analyses of the time profiles of the doped droplets, we identify two distinct groups of droplets. The faster group has a