Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Joseph J. McDonald"'
Autor:
Mary E Matyskiela, Thomas Clayton, Philip P Chamberlain, Aaron Carpenter, Mark Rolfe, Barbra Pagarigan, Joseph J. McDonald, Gang Lu, Eileen Tran, Christopher Mayne, Lawrence G Hamann, Xinde Zheng
Publikováno v:
Nature Structural & Molecular Biology. 27:319-322
Thalidomide-dependent degradation of the embryonic transcription factor SALL4 by the CRL4CRBN E3 ubiquitin ligase is a plausible major driver of thalidomide teratogenicity. The structure of the second zinc finger of SALL4 in complex with pomalidomide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7210984ec5e6072f87bb4c0493f947fc
https://doi.org/10.1038/s41594-020-0405-9
https://doi.org/10.1038/s41594-020-0405-9
Autor:
JOHN Malona, CLAUDIO CHUAQUI, BORIS M. SELETSKY, LISA BEEBE, SUSAN CANTIN, DANIEL VAN KALKEN, KELLY FAHNOE, ZHIGANG WANG, BETH BROWNING, HILARY SZABO, LOUISE A. KOOPMAN, TAMAS ORAVECZ, JOSEPH J. MCDONALD, FRANCISCO RAMIREZ-VALLE, RAJULA GAUR, KOFI A. MENSAH, MICHAEL THOMAS, JAMIE N. CONNARN, HAIQING HU, MATTHEW D. ALEXANDER, ALAN F. CORIN
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 249
As an anti-inflammatory strategy, MAPK-activated protein kinase-2 (MK2) inhibition can potentially avoid the clinical failures seen for direct p38 inhibitors, especially tachyphylaxis. CC-99677, a selective targeted covalent MK2 inhibitor, employs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6afca613da09ae7ab956e9811531b01
https://pubmed.ncbi.nlm.nih.gov/35691544
https://pubmed.ncbi.nlm.nih.gov/35691544
Autor:
Michael David Rogers, Jeffery N. Carroll, Mark A. Massa, Jeffrey Hitchcock, Peter G. Ruminski, Michelle A. Schmidt, Bruce C. Hamper, Strohbach Joseph Walter, Huey S. Shieh, Laurence O. Whiteley, Katherine E. Palmquist, Joe T. Collins, Grace E. Munie, Hanau Cathleen E, H. Peter Kleine, Mark E. Schnute, T. Sunyer, Nicole Caspers, John E. Baldus, Theresa R. Fletcher, Joseph J. McDonald, Silvia Portolan, Jeffrey A. Scholten, Dean Messing, Margaret L. Grapperhaus, Brandon Collins
Publikováno v:
Journal of Medicinal Chemistry. 59:313-327
Matrix metalloproteinase-13 (MMP-13) is a zinc-dependent protease responsible for the cleavage of type II collagen, the major structural protein of articular cartilage. Degradation of this cartilage matrix leads to the development of osteoarthritis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1bf588f2b187240a5d8f4d5ee2e305b
https://doi.org/10.1021/acs.jmedchem.5b01434
https://doi.org/10.1021/acs.jmedchem.5b01434
Autor:
David J. Richard, Julie Lee, Alessandro Moretto, Seungil Han, Kristin Janz, Neelu Kaila, Mark Ryan, Cristina Aevazelis, Lori Fitz, Jeanne Chang, Zhao-Kui Wan, Atli Thorarensen, Joseph J. McDonald, Christoph Martin Dehnhardt, Frank Lovering, Nikolaos Papaioannou, William M. Moore
Publikováno v:
ChemMedChem. 11:217-233
There has been significant interest in spleen tyrosine kinase (Syk) owing to its role in a number of disease states, including autoimmunity, inflammation, and cancer. Ongoing therapeutic programs have resulted in several compounds that are now in cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a6255c9f97bdb8a6eb686270c2250c
https://doi.org/10.1002/cmdc.201500333
https://doi.org/10.1002/cmdc.201500333
Publikováno v:
Journal of chemical theory and computation. 12(4)
Epidermal growth factor receptor (EGFR) inhibitors interrupt EGFR-dependent cellular signaling pathways that lead to accelerated tumor growth and proliferation. Mutation of a threonine in the inhibitor binding pocket, known as the "gatekeeper", to me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb9b01392702a7ca7a0d94b62b2239a
https://pubmed.ncbi.nlm.nih.gov/27010480
https://pubmed.ncbi.nlm.nih.gov/27010480
Publikováno v:
Biophysical Journal. 110(3)
Small molecular inhibitors of receptor kinases suppress cellular signaling pathways mediated by the proteins that lead to malignant cell growth and division. We have studied molecular interactions between epidermal grow factor receptor (EGFR) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2fd2918461b816053dd9aea1a47bb1
Autor:
Julie Lee, Paul Alan Glossop, Atli Thorarensen, Yogesh A. Sabnis, Christopher Phillips, Lori Fitz, Frank Lovering, Andrew F. Bent, Ravi G. Kurumbail, Gavin A. Whitlock, Jeanne S. Chang, Seungil Han, Joseph J. McDonald, Mark Ryan
Publikováno v:
Chemical Biology & Drug Design. 80:657-664
Spleen tyrosine kinase is a non-receptor tyrosine kinase, overactivation of which is thought to contribute to autoimmune diseases as well as allergy and asthma. Protein kinases have a highly conserved ATP binding site, thus making challenging the des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81eec67ddbf92c294b02b1501935574d
https://doi.org/10.1111/j.1747-0285.2012.01443.x
https://doi.org/10.1111/j.1747-0285.2012.01443.x
Autor:
Jeffery N. Carroll, Craig Swearingen, Decrescenzo Gary A, Rico Joseph G, Theresa R. Fletcher, Daniel P. Becker, Joseph J. McDonald, Susan L. Hockerman, Grace E. Munie, Stephen A. Kolodziej, Boehm Terri L, Debbie A. Mischke, Nathan W. Stehle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3557-3560
A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b61c5bde65513f60ea0896cfb24e7ec
https://doi.org/10.1016/j.bmcl.2010.04.130
https://doi.org/10.1016/j.bmcl.2010.04.130
Autor:
Daniel P. Becker, Theresa R. Fletcher, Debbie A. Mischke, Joseph J. McDonald, Stephen A. Kolodziej, Nathan W. Stehle, Susan L. Hockerman, Grace E. Munie, Craig Swearingen, Decrescenzo Gary A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3561-3564
A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e95e2ec754d4d05a448abe4797fbdd4
https://doi.org/10.1016/j.bmcl.2010.04.111
https://doi.org/10.1016/j.bmcl.2010.04.111
Autor:
John N. Freskos, Yvette M. Fobian, Timothy E. Benson, Michael J. Bienkowski, David L. Brown, Thomas L. Emmons, Robert Heintz, Alice Laborde, Joseph J. McDonald, Brent V. Mischke, John M. Molyneaux, Joseph B. Moon, Patrick B. Mullins, D. Bryan Prince, Donna J. Paddock, Alfredo G. Tomasselli, Gregory Winterrowd
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:73-77
We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e643373fd67faba63c23379fdd0447
https://doi.org/10.1016/j.bmcl.2006.09.092
https://doi.org/10.1016/j.bmcl.2006.09.092