Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Joseph J. Korte"'
Autor:
Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz
Publikováno v:
Toxicol Sci
Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical
Autor:
Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung
Publikováno v:
Toxicol Sci
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses
Autor:
Jennifer H. Olker, Joseph J. Korte, Jonathan T. Haselman, Michael W. Hornung, Sigmund J. Degitz
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 249
The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical di
Autor:
Joseph J. Korte, Sigmund J. Degitz, Phillip C. Hartig, Jessica P Christensen, Jennifer H Olker, Paige M Kent, Carsten Knutsen, Mary C. Cardon, Michael W. Hornung, Jeffrey S. Denny
Publikováno v:
Toxicological Sciences. 168:430-442
Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical
Autor:
Sigmund J. Degitz, Jennifer H Olker, Phillip C. Hartig, Mary C. Cardon, Jonathan T. Haselman, Joseph J. Korte, Jeffrey S. Denny, Michael W. Hornung
Publikováno v:
Toxicol In Vitro
The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption. This highly conserved enzyme plays an essential role in maintaining
Autor:
Joseph J. Korte, Jonathan T. Haselman, Patricia A. Kosian, Sigmund J. Degitz, Allen W. Olmstead
Publikováno v:
Aquatic Toxicology. 199:240-251
The Larval Amphibian Growth and Development Assay (LAGDA) is an internationally harmonized testing guideline for evaluating effects of chronic chemical exposure in amphibians. In order to evaluate the effects of chronic exposure to an antiandrogenic
Autor:
Joseph J. Korte, Sally A. Mayasich, Phillip C. Hartig, Michael W. Hornung, Jennifer H Olker, Joseph O’Flanagan, Sigmund J. Degitz, Jeffrey S. Denny, Philip DeGoey
Publikováno v:
Toxicol In Vitro
Deiodinase enzymes are critical for tissue-specific and temporal control of activation or inactivation of thyroid hormones during vertebrate development, including amphibian metamorphosis. We previously screened ToxCast chemicals for inhibitory activ
Autor:
Joseph J. Korte, Sigmund J. Degitz, Rodney D. Johnson, Yasushi Goto, Naoko Watanabe, Yu Onoda, Patricia A. Kosian, Yuta Onishi, Maki Sakurai, Taisen Iguchi, Jonathan T. Haselman, Yuki Ito
Publikováno v:
Journal of Applied Toxicology. 36:1651-1661
The Larval Amphibian Growth and Development Assay (LAGDA) is a globally harmonized chemical testing guideline developed by the U.S. Environmental Protection Agency in collaboration with Japan's Ministry of Environment to support risk assessment. The
Autor:
Patricia A. Kosian, Sigmund J. Degitz, Rodney D. Johnson, Jonathan T. Haselman, Taisen Iguchi, Joseph J. Korte, Allen W. Olmstead
Publikováno v:
Journal of Applied Toxicology. 36:1639-1650
The Larval Amphibian Growth and Development Assay (LAGDA) is a globally harmonized test guideline developed by the U.S. Environmental Protection Agency in collaboration with Japan's Ministry of the Environment. The LAGDA was designed to evaluate apic
Autor:
Michael W. Hornung, Jennifer H Olker, Sigmund J. Degitz, Chad A. Blanksma, Jonathan T. Haselman, Joseph J. Korte, Patricia A. Kosian, Kelby G Donnay
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 166(2)
The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces available iodide for thyroid hormone synthesis, which