Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joseph J. Kopcho"'
Autor:
and Juergen M. Schanzer, James B. Wiesner, Jay DaRe, Joseph J. Kopcho, Mark D. Erion, Angelo J. Castellino, Bheemarao G. Ugarkar
Publikováno v:
Journal of Medicinal Chemistry. 43:2883-2893
Adenosine receptor agonists produce a wide variety of therapeutically useful pharmacologies. However, to date they have failed to undergo successful clinical development due to dose-limiting side effects. Adenosine kinase inhibitors (AKIs) represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3f55e87ad3ee4daefc2927c4c517af
https://doi.org/10.1021/jm000024g
https://doi.org/10.1021/jm000024g
Autor:
Serge H. Boyer, Mark D. Erion, Bheemarao G. Ugarkar, Joel Solbach, Rohan Mendonca, Joseph J. Kopcho, Atsushi Nagahisa, and James B. Wiesner, Michael C. Matelich, Megumi Tsuchiya, Kristin Ollis, Jorge Gomez-Galeno, Masami Nakane
Publikováno v:
Journal of medicinal chemistry. 48(20)
Adenosine is an endogenous neuromodulator that when produced in the central and the peripheral nervous systems has anticonvulsant, anti-inflammatory, and analgesic properties. However, efforts to use adenosine receptor agonists are plagued by dose-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd72d52418a0b181f816226c51a60116
https://pubmed.ncbi.nlm.nih.gov/16190769
https://pubmed.ncbi.nlm.nih.gov/16190769
Autor:
Angelo J. Castellino, Michele Ramirez-Weinhouse, Jay S. DaRe, Joseph J. Kopcho, Bheemarao G. Ugarkar, Mark D. Erion, and Sanna Rosengren
Publikováno v:
Journal of medicinal chemistry. 46(22)
Chronic inflammatory diseases, such as arthritis and rheumatoid arthritis, remain major health problems worldwide. We previously demonstrated that adenosine kinase inhibitors (AKIs) exhibit antiinflammatory effects by inhibiting TNF-alpha production,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8e0da7a659c144dbf26871a09d1085
https://pubmed.ncbi.nlm.nih.gov/14561094
https://pubmed.ncbi.nlm.nih.gov/14561094
Autor:
Bheemarao G. Ugarkar, Angelo J. Castellino, Jay M. DaRe, Joseph J. Kopcho, James B. Wiesner, Juergen M. Schanzer, Mark D. Erion
Publikováno v:
Journal of medicinal chemistry. 43(15)
In the preceding article (Ugarkar et al. J. Med. Chem. 2000, 43) we reported that analogues of tubercidin are potent adenosine kinase (AK) inhibitors with antiseizure activity in the rat maximum electroshock (MES) model. Despite the discovery of seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b184bff86ca2e47f89d872d18dd41188
https://pubmed.ncbi.nlm.nih.gov/10956197
https://pubmed.ncbi.nlm.nih.gov/10956197
Autor:
Boyer SH; Metabasis Therapeutics Inc., 9390 Towne Centre Drive, San Diego, California 92121, USA. boyer@mbasis.com, Ugarkar BG, Solbach J, Kopcho J, Matelich MC, Ollis K, Gomez-Galeno JE, Mendonca R, Tsuchiya M, Nagahisa A, Nakane M, Wiesner JB, Erion MD
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2005 Oct 06; Vol. 48 (20), pp. 6430-41.