Výsledky vyhledávání - "Joseph J. Brazil"

Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells

Autor: Lisa Koodie, Scott B. Selleck, Charles Peters, Morayma Reyes, Sally E. Stringer, Robert C.H. Zhao, Joseph J. Brazil, Chendong Pan, Pankaj Gupta, Elliot J. Stephenson, Matthew S. Nelson

Publikováno v: Blood. 106:1956-1964

In mucopolysaccharidosis-I (MPS-I), α-L-iduronidase deficiency leads to progressive heparan sulfate (HS) and dermatan sulfate (DS) glycosaminoglycan (GAG) accumulation. The functional consequences of these accumulated molecules are unknown. HS criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497b544f411ae437edc9cad9363b5f90
https://doi.org/10.1182/blood-2005-02-0657

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Constitutive Expression of the Fas Receptor and Its Ligand in Adult Human Bone Marrow: A Regulatory Feedback Loop for the Homeostatic Control of Hematopoiesis

Autor: Joseph J. Brazil, Pankaj Gupta

Publikováno v: Blood Cells, Molecules, and Diseases. 29:94-103

ABSTRACT Fas ligand (FasL) mediated apoptosis in the bone marrow may contribute to suppression of hematopoiesis in myelodysplastic syndromes (MDS) and in aplastic anemia, and also to the regulation of normal erythropoiesis. To identify potential effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1311ecb803870b5358724e44575c3d
https://doi.org/10.1006/bcmd.2002.0539

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Structurally Specific Heparan Sulfates Support Primitive Human Hematopoiesis by Formation of a Multimolecular Stem Cell Niche

Autor: Joseph J. Brazil, Theodore R. Oegema, Pankaj Gupta, Arkadiusz Z. Dudek, Arne Slungaard, Catherine M. Verfaillie

Publikováno v: Scopus-Elsevier

Stem cell localization, conservation, and differentiation is believed to occur in niches in the marrow stromal microenvironment. Our recent observation that long-term in vitro human hematopoiesis requires a stromal heparan sulfate proteoglycan (HSPG)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f63d4a4a2bb09f6b8cd79cac2d05b84
https://doi.org/10.1182/blood.v92.12.4641.424k10_4641_4651

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Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: Requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins

Autor: Arne Slungaard, Catherine M. Verfaillie, Pankaj Gupta, Arkaduisz Z. Dudek, Joseph J. Brazil, Theodore R. Oegema

Publikováno v: Scopus-Elsevier
Web of Science

We have shown that stromal O-sulfated heparan sulfate glycosaminoglycans (O-S-GAGs) regulate primitive human hematopoietic progenitor cell (HPC) growth and differentiation by colocalizing heparin-binding cytokines and matrix proteins with HPC in stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f09190fc03ee76e1352e565659c8792
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033957697&partnerID=MN8TOARS

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