Výsledky vyhledávání - "Joseph J LoTurco"

Akademický článek

Disordered breathing in a mouse model of Dravet syndrome

Autor: Fu-Shan Kuo, Colin M Cleary, Joseph J LoTurco, Xinnian Chen, Daniel K Mulkey

Publikováno v: eLife, Vol 8 (2019)

Dravet syndrome (DS) is a form of epilepsy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Respiratory failure is a leading cause of SUDEP, and DS patients’ frequently exhibit disordered breathing. Despite this, mechanisms und

Externí odkaz: https://doaj.org/article/7de89762413e4415b7d278313cc29671

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Akademický článek

Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.

Autor: Aleksey Malyshev, Roman Goz, Joseph J LoTurco, Maxim Volgushev

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0122286 (2015)

Understanding single-neuron computations and encoding performed by spike-generation mechanisms of cortical neurons is one of the central challenges for cell electrophysiology and computational neuroscience. An established paradigm to study spike enco

Externí odkaz: https://doaj.org/article/524dc05c5fb64076952c9c1eae2a7683

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Akademický článek

Mechanistic studies of the genetically encoded fluorescent protein voltage probe ArcLight.

Autor: Zhou Han, Lei Jin, Fuyi Chen, Joseph J Loturco, Lawrence B Cohen, Alexey Bondar, Josef Lazar, Vincent A Pieribone

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113873 (2014)

ArcLight, a genetically encoded fluorescent protein voltage probe with a large ΔF/ΔV, is a fusion between the voltage sensing domain of the Ciona instestinalis voltage sensitive phosphatase and super ecliptic pHluorin carrying a single mutation (A2

Externí odkaz: https://doaj.org/article/cd9d565a88584daeaddd3ccdb6366328

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Akademický článek

Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.

Autor: Tracy M Centanni, Fuyi Chen, Anne M Booker, Crystal T Engineer, Andrew M Sloan, Robert L Rennaker, Joseph J LoTurco, Michael P Kilgard

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98439 (2014)

In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound di

Externí odkaz: https://doaj.org/article/bb9f33bb24d04819a98f4f4a4fefefd8

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Akademický článek

Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.

Autor: Brady J Maher, Joseph J LoTurco

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e34053 (2012)

The pathophysiology of schizophrenia is believed to involve defects in synaptic transmission, and the function of many schizophrenia-associated genes, including DISC1, have been linked to synaptic function at glutamatergic synapses. Here we develop a

Externí odkaz: https://doaj.org/article/5bbe260f59c648eea0bb69da2df889d0

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Akademický článek

ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.

Autor: Matthew J Girgenti, Joseph J LoTurco, Brady J Maher

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32404 (2012)

ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide statistical significance for association with a combined diagnosis of schizophrenia (SZ) and bip

Externí odkaz: https://doaj.org/article/e303dfbf66f641d1b2241c1734a8f831

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