Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joseph J Lancman"'
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
Autor:
Ryan J Geusz, Allen Wang, Joshua Chiou, Joseph J Lancman, Nichole Wetton, Samy Kefalopoulou, Jinzhao Wang, Yunjiang Qiu, Jian Yan, Anthony Aylward, Bing Ren, P Duc Si Dong, Kyle J Gaulton, Maike Sander
Publikováno v:
eLife, Vol 10 (2021)
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we investigated contributions of regulatory programs active during pancreatic development to T2D ri
Externí odkaz:
https://doaj.org/article/ae2ad6bb2f8440508324b4fcde2ff75c
Autor:
Dorit Hockman, Alan J Burns, Gerhard Schlosser, Keith P Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, Gokhan Unlu, Ela W Knapik, Charles K Kaufman, Christian Mosimann, Leonard I Zon, Joseph J Lancman, P Duc S Dong, Heiko Lickert, Abigail S Tucker, Clare V H Baker
Publikováno v:
eLife, Vol 6 (2017)
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which ar
Externí odkaz:
https://doaj.org/article/90ee98c22520473bb323c934cc72f10b
Autor:
Xiaolin Ai, Zengpanpan Ye, Chaoxin Xiao, Jian Zhong, Joseph J. Lancman, Xuelan Chen, Xiangyu Pan, Yu Yang, Lin Zhou, Xiang Wang, Huashan Shi, Dongmei Zhang, Yuqin Yao, Dan Cao, Chengjian Zhao
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
An accurate prediction of the intracranial infiltration tendency and drug response of individual glioblastoma (GBM) cells is essential for personalized prognosis and treatment for this disease. However, the clinical utility of mouse patient-derived o
Externí odkaz:
https://doaj.org/article/61dea9b1204249fe97e11002a8215fb4
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3146-3151 (2018)
Summary: A standard approach in the identification of transcriptional enhancers is the use of transgenic animals carrying DNA elements joined to reporter genes inserted randomly in the genome. We examined elements near Tbx5, a gene required for forel
Externí odkaz:
https://doaj.org/article/efb2be0a509b43199ea7a43d938ee017
Autor:
Danhua Zhang, Keith P. Gates, Lindsey Barske, Guangliang Wang, Joseph J. Lancman, Xin-Xin I. Zeng, Megan Groff, Kasper Wang, Michael J. Parsons, J. Gage Crump, P. Duc Si Dong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The hepatopancreatic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for their lineage specification is unclear. Here, the authors reveal that Notch ligands Jagged1b and Jagged2b induce duct cell l
Externí odkaz:
https://doaj.org/article/9a869d75f80549c8a2ff75e1bc7269a8
Autor:
Keith P. Gates, P. Duc Si Dong, Jonathan Matalonga, Jiaye He, Chong Chen, Lindsey Barske, Jan Huisken, Dan Cao, Yi Yang, Chengjian Zhao, Alyssa Graves, Xiangyu Pan, Joseph J. Lancman
Publikováno v:
Hepatology
Alagille Syndrome (ALGS) is a congenital disorder caused by mutations in the Notch ligand gene JAGGED1, leading to neonatal loss of intrahepatic duct (IHD) cells and cholestasis. Cholestasis can resolve in certain patients with ALGS, suggesting regen
Autor:
Chengjian Zhao, Jonathan Matalonga, Joseph J. Lancman, Lu Liu, Chaoxin Xiao, Shiv Kumar, Keith P. Gates, Jiaye He, Alyssa Graves, Jan Huisken, Mizuki Azuma, Zhenghao Lu, Chong Chen, Bi-Sen Ding, P. Duc Si Dong
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Despite the robust healing capacity of the liver, regenerative failure underlies numerous hepatic diseases, including the JAG1 haploinsufficient disorder, Alagille syndrome (ALGS). Cholestasis due to intrahepatic duct (IHD) paucity resolves in certai
Autor:
Marie Kmita, Yacine Kherdjemil, John F. Fallon, Takayuki Suzuki, Joseph J. Lancman, Sean M. Hasso, Marian A Ros, P Duc S Dong, Andrea Ferris
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 251(9)
[Background]: The phalanges are the final skeletal elements to form in the vertebrate limb and their identity is regulated by signaling at the phalanx forming region (PFR) located at the tip of the developing digit ray. Here, we seek to explore the r
Autor:
Joanna Smeeton, Crump Jg, Kuo-Chang Tseng, Joseph J. Lancman, Dong Pds, Peter Fabian, Robert Cerny
Publikováno v:
Yearbook of Paediatric Endocrinology.
Autor:
Xiaolin Ai, Zengpanpan Ye, Chaoxin Xiao, Jian Zhong, Joseph J. Lancman, Xuelan Chen, Xiangyu Pan, Yu Yang, Lin Zhou, Xiang Wang, Huashan Shi, Dongmei Zhang, Yuqin Yao, Dan Cao, Chengjian Zhao
Publikováno v:
Disease modelsmechanisms. 15(4)
An accurate prediction of the intracranial infiltration tendency and drug response of individual glioblastoma (GBM) cells is essential for personalized prognosis and treatment for this disease. However, the clinical utility of mouse patient-derived o