Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joseph J E Caesar"'
Autor:
Ilse Jongerius, Hayley Lavender, Lionel Tan, Nicola Ruivo, Rachel M Exley, Joseph J E Caesar, Susan M Lea, Steven Johnson, Christoph M Tang
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003528 (2013)
Neisseria meningitidis is a leading cause of sepsis and meningitis. The bacterium recruits factor H (fH), a negative regulator of the complement system, to its surface via fH binding protein (fHbp), providing a mechanism to avoid complement-mediated
Externí odkaz:
https://doaj.org/article/cb5ebf2b7dc04e1d853c66d45d0ea94c
Autor:
Joseph J. E. Caesar, Andreas Zeitler, Samuel Wagner, Joseph Fisher, Sandra Bäurle, Lucas Kuhlen, Justin C. Deme, Susan M. Lea, Rebecca Debo, Steven Johnson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Protein secretion through type-three secretion systems (T3SS) is critical for motility and virulence of many bacteria. Proteins are transported through an export gate containing three proteins (FliPQR in flagella, SctRST in virulence systems). A four
Autor:
Joseph J. E. Caesar, Ashley L. Nord, Justin C. Deme, Emily Furlong, Fabienne F. V. Chevance, Susan M. Lea, Kelly T. Hughes, Richard M. Berry, Steven Johnson
Publikováno v:
Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2021, 6 (6), pp.712-721. ⟨10.1038/s41564-021-00895-y⟩
Nature Microbiology, 2021, 6 (6), pp.712-721. ⟨10.1038/s41564-021-00895-y⟩
Nature microbiology
Nature Microbiology, Nature Publishing Group, 2021, 6 (6), pp.712-721. ⟨10.1038/s41564-021-00895-y⟩
Nature Microbiology, 2021, 6 (6), pp.712-721. ⟨10.1038/s41564-021-00895-y⟩
Nature microbiology
The bacterial flagellum is a macromolecular protein complex that enables motility in many species. Bacterial flagella self-assemble a strong, multicomponent drive shaft that couples rotation in the inner membrane to the micrometre-long flagellar fila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cc37b48b32dfbb7e3e638d1962a3bb
https://hal.archives-ouvertes.fr/hal-03411637
https://hal.archives-ouvertes.fr/hal-03411637
Autor:
Steven Johnson, Joseph J. E. Caesar, Chiara Machello, Susan M. Lea, Molly L. Tang, Simon Kiesewetter, Justin C. Deme, Dominika Elmlund, Hans Elmlund, Cyril F. Reboul
Publikováno v:
Journal of Structural Biology: X
Journal of Structural Biology: X, Vol 4, Iss, Pp 100040-(2020)
Journal of Structural Biology: X, Vol 4, Iss, Pp 100040-(2020)
Graphical abstract
We here introduce the third major release of the SIMPLE (Single-particle IMage Processing Linux Engine) open-source software package for analysis of cryogenic transmission electron microscopy (cryo-EM) movies of single-particl
We here introduce the third major release of the SIMPLE (Single-particle IMage Processing Linux Engine) open-source software package for analysis of cryogenic transmission electron microscopy (cryo-EM) movies of single-particl
Autor:
Steven Johnson, Simon Kiesewetter, Susan M. Lea, Hans Elmlund, Justin C. Deme, Cyril F. Reboul, Dominika Elmlund, Chiara Machello, Joseph J. E. Caesar, Molly L. Tang
Publikováno v:
Journal of structural biology. 212(3)
Autor:
T. Sakari Jokiranta, Ádám I. Csincsi, Mihály Józsi, Joseph J. E. Caesar, Agustín Tortajada, Barbara Uzonyi, Éva Kárpáti, Zsóka Szabó, Marcell Cserhalmi, Susan M. Lea, Zoltán Prohászka, Zsófia Bánlaki, Santiago Rodríguez de Córdoba
Publikováno v:
The Journal of Immunology. 199:292-303
Factor H–related protein (FHR) 1 is one of the five human FHRs that share sequence and structural homology with the alternative pathway complement inhibitor FH. Genetic studies on disease associations and functional analyses indicate that FHR-1 enh
Autor:
Lucas Kuhlen, Justin C. Deme, Susan M. Lea, Samuel Wagner, Mehari Tesfazgi Mebrhatu, Boris Macek, Steven Johnson, Tariq Ganief, Patrizia Abrusci, Tobias Dietsche, Joseph J. E. Caesar, Carol V. Robinson, Joseph Gault
Publikováno v:
Nature structural & molecular biology
SummaryExport of proteins through type three secretion systems is critical for bacterial motility and virulence of many major bacterial pathogens. Three putative integral membrane proteins (FliP/FliQ/FliR) are suggested to form the core of an export
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190f44035360f0a1ed1efb5442ee29df
Autor:
Miklós Zöldi, Mihály Józsi, Zsófia Bánlaki, Matthew C. Pickering, Kenji Daigo, Anne Kopp, Susan M. Lea, Takao Hamakubo, Joseph J. E. Caesar, Elena Goicoechea de Jorge, Ádám I. Csincsi, Barbara Uzonyi, Mario Hebecker
Publikováno v:
The Journal of Immunology Author Choice
The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense depo
Publikováno v:
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
The structure of ErpC, a member of the complement regulator-acquiring surface protein family from B. burgdorferi, has been solved, providing insights into the strategies of complement evasion by this zoonotic bacterium and suggesting a common archite
Autor:
Joseph J. E. Caesar, Olga Lissina, Susanne Leonhartsberger, Isabelle Maillet, Pietro Roversi, Nurfilza Ahmat, Susan M. Lea, Guido C. Paesen, Miles A. Nunn, Mauro Martin Teixeira, Wilhelm Boland, Bernhard Ryffel, Kerstin Ploss, Dieudonnée Togbe
Publikováno v:
The Journal of Biological Chemistry
'Journal of Biological Chemistry ', vol: 288, pages: 18789-18802 (2013)
'Journal of Biological Chemistry ', vol: 288, pages: 18789-18802 (2013)
Background: OmCI is an ectoparasite-derived anti-inflammatory protein that binds LTB4 and prevents complement C5 activation. Results: The C5 and LTB4 binding activities of OmCI are functionally and structurally independent, and OmCI potently inhibits