Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joseph J Babcock"'
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118324 (2015)
Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals. Current knowledge of this phenomenon is derived from a limited number of
Externí odkaz:
https://doaj.org/article/6c53b124ae4a4b0298bc73525366661a
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69513 (2013)
Growing evidence suggests that drugs interact with diverse molecular targets mediating both therapeutic and toxic effects. Prediction of these complex interactions from chemical structures alone remains challenging, as compounds with different struct
Externí odkaz:
https://doaj.org/article/51105cb1d7f8493688654b22e4cd4c4f
Autor:
Andrew J. Storaska, Levi L. Blazer, Corey R. Hopkins, Owen B. McManus, Joseph J. Babcock, Zhihong Lin, Jian P. Mei, Benita Sjögren, Susan M. Wade, Richard R. Neubig, Craig W. Lindsley, Min Li, Meng Wu
Publikováno v:
Cellular Signalling. 25:2848-2855
Regulator of G-protein signaling (RGS) proteins potently suppress G-protein coupled receptor (GPCR) signal transduction by accelerating GTP hydrolysis on activated heterotrimeric G-protein α subunits. RGS4 is enriched in the CNS and is proposed as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198692137d7fe65ddfe279e9703d2763
https://doi.org/10.1016/j.cellsig.2013.09.007
https://doi.org/10.1016/j.cellsig.2013.09.007
Autor:
Min Li, Joseph J. Babcock
Publikováno v:
Acta Pharmacologica Sinica
The sequencing of the human genome has fueled the last decade of work to functionally characterize genome content. An important subset of genes encodes membrane proteins, which are the targets of many drugs. They reside in lipid bilayers, restricting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e1626c2081b4559862ff5f510c7780
https://doi.org/10.1038/aps.2013.142
https://doi.org/10.1038/aps.2013.142
Autor:
Joseph J. Babcock, Min Li
Publikováno v:
Acta Pharmacologica Sinica
Most drugs acting on the cell surface receptors are membrane permeable and thus able to engage their target proteins in different subcellular compartments. However, these drugs' effects on cell surface receptors have historically been studied on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd9387ac70321bdec65299c439c5830
https://doi.org/10.1038/aps.2013.51
https://doi.org/10.1038/aps.2013.51
Autor:
Joseph J. Babcock, Min Li
Publikováno v:
Acta Pharmacologica Sinica
To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21b53f8b3b48494dda04e11a283cd79
https://doi.org/10.1038/aps.2013.6
https://doi.org/10.1038/aps.2013.6
Autor:
Owen B. McManus, Alessandra Moretti, Beiyan Zou, Hongkang Zhang, Fajun Nan, Xiaoying Wang, Wei Yan, Joseph J. Babcock, Haibo Yu, Gordon F. Tomaselli, Milena Bellin, Min Li, Karl-Ludwig Laugwitz
Publikováno v:
Proceedings of the National Academy of Sciences. 109:11866-11871
Long QT syndrome (LQTS) is a genetic disease characterized by a prolonged QT interval in an electrocardiogram (ECG), leading to higher risk of sudden cardiac death. Among the 12 identified genes causal to heritable LQTS, ∼90% of affected individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815862729465a1409c9c02f424374fa4
https://doi.org/10.1073/pnas.1205266109
https://doi.org/10.1073/pnas.1205266109
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118324 (2015)
PLoS ONE
PLoS ONE
Promiscuous inhibition of the human ether-a-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals. Current knowledge of this phenomenon is derived from a limited number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599f095ac6a9f5450b12309fb52db831
http://europepmc.org/articles/PMC4336329?pdf=render
http://europepmc.org/articles/PMC4336329?pdf=render
The unintended and often promiscous inhibition of the cardiac human Ether-à-go-go related gene (hERG) potassium channel is a common cause for either delay or removal of therapeutic compounds from development and withdrawal of marketed drugs. The cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4070e23d628a40d0ae48310157cee6e5
https://europepmc.org/articles/PMC3232635/
https://europepmc.org/articles/PMC3232635/
Autor:
Pritam Chanda, Joel S. Bader, Owen B. McManus, Beiyan Zou, Joseph J. Babcock, Haibo Yu, Min Li
Compound effects on cloned human Ether-a-go-go related gene (hERG) potassium channels have been used to assess the potential cardiac safety liabilities of drug development candidate compounds. In addition to radioactive ligand displacement tests, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d2fcf58050578f24eb962f5fa21e0e
https://europepmc.org/articles/PMC3002177/
https://europepmc.org/articles/PMC3002177/