Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joseph J, Illingworth"'
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the anti
Externí odkaz:
https://doaj.org/article/311198660694450bbebda7b48bd4d1b2
Autor:
Joseph J. Illingworth, Daniel G. Alanine, Rebecca Brown, Jennifer M. Marshall, Helen E. Bartlett, Sarah E. Silk, Geneviève M. Labbé, Doris Quinkert, Jee Sun Cho, Jason P. Wendler, David J. Pattinson, Lea Barfod, Alexander D. Douglas, Michael W. Shea, Katherine E. Wright, Simone C. de Cassan, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically. RH5 is one of the leading blood-stage Plasmodium falciparum malaria vaccin
Externí odkaz:
https://doaj.org/article/8f0bf423994b483e9013cc4f10cd07fc
Autor:
Daria Nikolaeva, Sumi Biswas, Iona J. Brian, Daniel G. W. Alanine, Kazutoyo Miura, Simon J. Draper, Carole A. Long, Alex Fyfe, Yuanyuan Li, Dari F. Da, Anna Cohuet, Joseph J. Illingworth
Publikováno v:
Molecular & Cellular Proteomics : MCP
The malaria agent Plasmodium falciparum continues to evade control efforts. Despite multiple datasets for the Plasmodium sexual-stage transcriptome and proteome, there have been no rational screens to identify candidate antigens for transmission-bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f821cdbb40de9639e9ac5dbf4bfe2bea
https://doi.org/10.1074/mcp.ra117.000036
https://doi.org/10.1074/mcp.ra117.000036
Autor:
Robert J, Ragotte, David, Pulido, Amelia M, Lias, Doris, Quinkert, Daniel G W, Alanine, Abhishek, Jamwal, Hannah, Davies, Adéla, Nacer, Edward D, Lowe, Geoffrey W, Grime, Joseph J, Illingworth, Robert F, Donat, Elspeth F, Garman, Paul W, Bowyer, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Nature communications. 13(1)
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7661131b60b6a79f4e393bbc0d9d5929
https://pubmed.ncbi.nlm.nih.gov/35177602
https://pubmed.ncbi.nlm.nih.gov/35177602
Autor:
Andrew R Williams, Alexander D Douglas, Kazutoyo Miura, Joseph J Illingworth, Prateek Choudhary, Linda M Murungi, Julie M Furze, Ababacar Diouf, Olivo Miotto, Cécile Crosnier, Gavin J Wright, Dominic P Kwiatkowski, Rick M Fairhurst, Carole A Long, Simon J Draper
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1002991 (2012)
No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficient
Externí odkaz:
https://doaj.org/article/153aa11fdecb435bb49161adefc69ec8
Autor:
Joseph J, Illingworth, Daniel G, Alanine, Rebecca, Brown, Jennifer M, Marshall, Helen E, Bartlett, Sarah E, Silk, Geneviève M, Labbé, Doris, Quinkert, Jee Sun, Cho, Jason P, Wendler, David J, Pattinson, Lea, Barfod, Alexander D, Douglas, Michael W, Shea, Katherine E, Wright, Simone C, de Cassan, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Frontiers in Immunology
The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically. RH5 is one of the leading blood-stage Plasmodium falciparum malaria vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f9907b0310175fe162cd2dec9651bd6
https://pubmed.ncbi.nlm.nih.gov/31214195
https://pubmed.ncbi.nlm.nih.gov/31214195
Autor:
Sara Eriksson, Francis M. Ndungu, Anna Färnert, Klara Lundblom, Josea Rono, Joseph J. Illingworth
Publikováno v:
European Journal of Immunology
Antibodies (Abs) are critical for immunity to malaria. However, Plasmodium falciparum specific Abs decline rapidly in absence of reinfection, suggesting impaired immunological memory. This study determines whether residents of Sweden that were treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0152a92ca6b451186d0d51d0ca3dd127
https://doi.org/10.1002/eji.201343630
https://doi.org/10.1002/eji.201343630
Autor:
Kathryn A, Hjerrild, Jing, Jin, Katherine E, Wright, Rebecca E, Brown, Jennifer M, Marshall, Geneviève M, Labbé, Sarah E, Silk, Catherine J, Cherry, Stine B, Clemmensen, Thomas, Jørgensen, Joseph J, Illingworth, Daniel G W, Alanine, Kathryn H, Milne, Rebecca, Ashfield, Willem A, de Jongh, Alexander D, Douglas, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Scientific Reports
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However it has proved challenging to identify a heterologous expression platf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c27f6ca2bfb0bd328787829a667c71f
https://pubmed.ncbi.nlm.nih.gov/27457156
https://pubmed.ncbi.nlm.nih.gov/27457156
Publikováno v:
Immunology. 135:198-206
Results from live-cell microscopy suggest that the behaviour of isolated components of the T-cell activation machinery in vitro does not represent the reality inside cells. Understanding the cellular-scale dynamics of microcluster migration can only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5032f41cc154edee606dbfb242b9fa3d
https://doi.org/10.1111/j.1365-2567.2011.03537.x
https://doi.org/10.1111/j.1365-2567.2011.03537.x