Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Joseph J, Heijnen"'
Autor:
Johan H. van Heerden, Meike T. Wortel, Frank J. Bruggeman, Joseph J. Heijnen, Yves J.M. Bollen, Robert Planqué, Josephus Hulshof, Tom G. O’Toole, S. Aljoscha Wahl, Bas Teusink
Publikováno v:
Microbial Cell, Vol 1, Iss 3, Pp 103-106 (2015)
In the model eukaryote Saccharomyces cerevisiae, it has long been known that a functional trehalose pathway is indispensable for transitions to high glucose conditions. Upon addition of glucose, cells with a defect in trehalose 6-phosphate synthase (
Externí odkaz:
https://doaj.org/article/dd2ccf032fec4f26af023e85a24c081a
Publikováno v:
Metabolites, Vol 4, Iss 2, Pp 347-372 (2014)
Microorganisms are constantly exposed to rapidly changing conditions, under natural as well as industrial production scale environments, especially due to large-scale substrate mixing limitations. In this work, we present an experimental approach bas
Externí odkaz:
https://doaj.org/article/b58fe519be49418eab993fb800f96b61
Autor:
Joan Albiol, Jan van Dam, Pau Ferrer, Marc Carnicer, Walter M. van Gulik, Angela ten Pierick, Joseph J. Heijnen
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Europe PubMed Central
Microbial Cell Factories, 11 (article 83), 2012
Microbial Cell Factories
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Microbial Cell Factories, Vol 11, Iss 1, p 83 (2012)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
instname
Europe PubMed Central
Microbial Cell Factories, 11 (article 83), 2012
Microbial Cell Factories
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Microbial Cell Factories, Vol 11, Iss 1, p 83 (2012)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Background Environmental and intrinsic stress factors can result in the global alteration of yeast physiology, as evidenced by several transcriptional studies. Hypoxia has been shown to have a beneficial effect on the expression of recombinant protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c8aaa8b93cf20370ee60e45e89f30e
http://hdl.handle.net/2072/400798
http://hdl.handle.net/2072/400798
Autor:
Amit T. Deshmukh, Joseph J. Heijnen, Jianye Xia, Henk J. Noorman, Yingping Zhuang, Ju Chu, Cees Haringa, Siliang Zhang, Junfei Zhao, Guan Wang, Wenjun Tang, Walter M. van Gulik
Publikováno v:
Microbial Biotechnology, 11(3)
Microbial Biotechnology
Microbial Biotechnology
In a 54 m3 large-scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20–40 s. Here, we used an intermittent feeding regime (IFR) and a two-compartment reactor (TCR) to mimic these
Autor:
Wenjun Tang, Henk J. Noorman, Walter M. van Gulik, Cees Haringa, Robert F. Mudde, Guan Wang, Ju Chu, Amit T. Deshmukh, Joseph J. Heijnen, Wouter A. van Winden
Publikováno v:
Chemical Engineering Science, 175
We assess the effect of substrate heterogeneity on the metabolic response of P. chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with Euler-Lagrange CFD simulations. In this work, we outline how this coupled hydrodyn
Autor:
Jianye Xia, Walter M. van Gulik, Amit T. Deshmukh, Cees Haringa, Guan Wang, Matthias Reuss, Wenjun Tang, Wouter A. van Winden, Joseph J. Heijnen, Henk J. Noorman, Ju Chu
Publikováno v:
Biotechnology and Bioengineering. 114:1733-1743
A powerful approach for the optimization of industrial bioprocesses is to perform detailed simulations integrating large-scale computational fluid dynamics (CFD) and cellular reaction dynamics (CRD). However, complex metabolic kinetic models containi
Autor:
Justina C. Wolters, Angela ten Pierick, Mark J. Hanemaaijer, S. A. Wahl, Joseph J. Heijnen, Camilo A. Suarez-Mendez
Publikováno v:
Metabolic Engineering Communications, 3, 52-63
Metabolic Engineering Communications, 3, 2016
Metabolic Engineering Communications, Vol 3, Iss, Pp 52-63 (2016)
Metabolic Engineering Communications, 3, 2016
Metabolic Engineering Communications, Vol 3, Iss, Pp 52-63 (2016)
13C labeling experiments in aerobic glucose limited cultures of Saccharomyces cerevisiae at four different growth rates (0.054; 0.101, 0.207, 0.307 h−1) are used for calculating fluxes that include intracellular cycles (e.g., storage carbohydrate c
Autor:
Joseph J. Heijnen, Cees Haringa, Jianye Xia, Henk J. Noorman, Amit T. Deshmukh, Wenjun Tang, Matthias Reuss, Robert F. Mudde
Publikováno v:
Engineering in Life Sciences
Engineering in Life Sciences, 16(7)
Engineering in Life Sciences, 16(7)
The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale fermentor under substrate limiting conditions were studied using an Euler-Lagrange computational fluid dynamics approach. The metabolic response to substr
Publikováno v:
Chemical Engineering Science. 145:31-44
In the search for advanced biofuels, microorganisms have been developed that make and secrete long chain hydrocarbons, resulting in a four phase fermentation mixture (cells, aqueous liquid, organic product, and (produced) gas). The product immiscibil