Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Joseph J, Cullen"'
Autor:
Kellie L. Bodeker, Brian J. Smith, Daniel J. Berg, Chandrikha Chandrasekharan, Saima Sharif, Naomi Fei, Sandy Vollstedt, Heather Brown, Meghan Chandler, Amanda Lorack, Stacy McMichael, Jared Wulfekuhle, Brett A. Wagner, Garry R. Buettner, Bryan G. Allen, Joseph M. Caster, Barbara Dion, Mandana Kamgar, John M. Buatti, Joseph J. Cullen
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103375- (2024)
Background: Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have poor 5-year survival. Pharmacological ascorbate (P-AscH-, high dose, intravenous, vitamin C) has shown promise as an adjunct to chemotherapy. We hypothesized adding P-A
Externí odkaz:
https://doaj.org/article/7a718d95f6c446c69fd37ed4334b67e1
Autor:
Juan Du, Amanda N. Pope, Brianne R. O’Leary, Brett A. Wagner, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract At pharmacological levels, ascorbate (P-AscH-) acts as a pro-oxidant by generating H2O2, depleting ATP in sensitive cells leading to cell death. The aim of this study was to determine the role of ATP production by oxidative phosphorylation o
Externí odkaz:
https://doaj.org/article/c43e8748fa3d45c9940de066f4152d51
Autor:
Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Rory S. Carroll, Garett J. Steers, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 13, Iss 3, p 361 (2024)
The toxicity of ionizing radiation limits its effectiveness in the treatment of pancreatic ductal adenocarcinoma. Pharmacologic ascorbate (P-AscH−) has been shown to radiosensitize pancreatic cancer cells while simultaneously radioprotecting normal
Externí odkaz:
https://doaj.org/article/d50be425446b432099130382021777a4
Autor:
Garett J. Steers, Brianne R. O’Leary, Juan Du, Brett A. Wagner, Rory S. Carroll, Frederick E. Domann, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1683 (2023)
Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverse
Externí odkaz:
https://doaj.org/article/43fcb3ed3d244d5f89e306ce3c3698cf
Autor:
Amira Zaher, Laura M. Stephens, Ann M. Miller, Stacey M. Hartwig, Jeffrey M. Stolwijk, Michael S. Petronek, Zeb R. Zacharias, Thaddeus J. Wadas, Varun Monga, Joseph J. Cullen, Muhammad Furqan, Jon C. D. Houtman, Steven M. Varga, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pharmacological ascorbate (i.e., intravenous infusions of vitamin C reaching ~ 20 mM in plasma) is under active investigation as an adjuvant to standard of care anti-cancer treatments due to its dual redox roles as an antioxidant in normal tissues an
Externí odkaz:
https://doaj.org/article/ae800cab6bcd4188b2c0616a5d74bf80
Autor:
Muhammad Furqan, Taher Abu-Hejleh, Laura M. Stephens, Stacey M. Hartwig, Sarah L. Mott, Casey F. Pulliam, Michael Petronek, John B. Henrich, Melissa A. Fath, Jon C. Houtman, Steven M. Varga, Kellie L. Bodeker, Aaron D. Bossler, Andrew M. Bellizzi, Jun Zhang, Varun Monga, Hariharasudan Mani, Marina Ivanovic, Brian J. Smith, Margaret M. Byrne, William Zeitler, Brett A. Wagner, Garry R. Buettner, Joseph J. Cullen, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102318- (2022)
Purpose: Platinum-based chemotherapy with or without immunotherapy is the mainstay of treatment for advanced stage non-small cell lung cancer (NSCLC) lacking a molecular driver alteration. Pre-clinical studies have reported that pharmacological ascor
Externí odkaz:
https://doaj.org/article/3029ad560b984a928c853c72d0650fca
Autor:
Rory S. Carroll, Juan Du, Brianne R. O'Leary, Garett Steers, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Free Radical Biology and Medicine. 204:108-117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e57d83880ff0cd1cf22309f6b8133eb
https://doi.org/10.1016/j.freeradbiomed.2023.04.023
https://doi.org/10.1016/j.freeradbiomed.2023.04.023
Autor:
Cameron M. Cushing, Michael S. Petronek, Kellie L. Bodeker, Sandy Vollstedt, Heather A. Brown, Emyleigh Opat, Nancy J. Hollenbeck, Thomas Shanks, Daniel J. Berg, Brian J. Smith, Mark C. Smith, Varun Monga, Muhammad Furqan, Matthew A. Howard, Jeremy D. Greenlee, Kranti A. Mapuskar, Joel St-Aubin, Ryan T. Flynn, Joseph J. Cullen, Garry R. Buettner, Douglas R. Spitz, John M. Buatti, Bryan G. Allen, Vincent A. Magnotta
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101804- (2021)
Pharmacological ascorbate (P-AscH-) combined with standard of care (SOC) radiation and temozolomide is being evaluated in a phase 2 clinical trial (NCT02344355) in the treatment of glioblastoma (GBM). Previously published data demonstrated that param
Externí odkaz:
https://doaj.org/article/ab946eefd1804c1cbcca282d6397675a
Autor:
Garett J. Steers, Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Hannah Van Beek, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 971 (2022)
Pancreatic cancer accounts for nearly one fourth of all new cancers worldwide. Little progress in the development of novel or adjuvant therapies has been made over the past few decades and new approaches to the treatment of pancreatic cancer are desp
Externí odkaz:
https://doaj.org/article/1bd5fc59cdc7407fa4643919bfc9d9ac
Autor:
Kristin E. Brandt, Kelly C. Falls, Joshua D. Schoenfeld, Samuel N. Rodman, Zhimin Gu, Fenghuang Zhan, Joseph J. Cullen, Brett A. Wagner, Garry R. Buettner, Bryan G. Allen, Daniel J. Berg, Douglas R. Spitz, Melissa A. Fath
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 82-87 (2018)
Pharmacological doses (> 1Â mM) of ascorbate (a.k.a., vitamin C) have been shown to selectively kill cancer cells through a mechanism that is dependent on the generation of H2O2 at doses that are safely achievable in humans using intravenous adminis
Externí odkaz:
https://doaj.org/article/959fae2b285c4504aa4c9bdc7bfe028d