A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion.

Autor: Joseph H R Hetmanski, Egor Zindy, Jean-Marc Schwartz, Patrick T Caswell

Publikováno v: PLoS Computational Biology, Vol 12, Iss 5, p e1004909 (2016)

Cell migration in 3D microenvironments is fundamental to development, homeostasis and the pathobiology of diseases such as cancer. Rab-coupling protein (RCP) dependent co-trafficking of α5β1 and EGFR1 promotes cancer cell invasion into fibronectin

Externí odkaz: https://doaj.org/article/42d6f3bda6bb4d6ca1341ea67f43efa7

Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration

Autor: Matthew Jones, Patrick T. Caswell, Fatima Chunara, Joseph H. R. Hetmanski, Jean-Marc Schwartz

Publikováno v: Hetmanski, J H R, Jones, M C, Chunara, F, Schwartz, J & Caswell, P T 2021, ' Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration ', PLoS Computational Biology, vol. 17, no. 3, e1008213, pp. e1008213 . https://doi.org/10.1371/journal.pcbi.1008213
PLoS Computational Biology, Vol 17, Iss 3, p e1008213 (2021)
PLoS Computational Biology

Cell migration in 3D microenvironments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely studied, the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738251a8ab68502cd5872d05d87baaa9
https://research.manchester.ac.uk/en/publications/a9f6cfcc-e704-4525-8b9f-7db4cd20da62

Membrane Tension Orchestrates Rear Retraction in Matrix Directed Cell Migration

Autor: Vanesa Sokleva, Oana Dobre, Ewa K. Paluch, Henry De Belly, Patrick T. Caswell, Joe Swift, Aránzazu del Campo, Nils Gauthier, Christophe Lamaze, Joseph H. R. Hetmanski, Roshna V. Nair, Angus J.M. Cameron, Jean-Marc Schwartz

Publikováno v: SSRN Electronic Journal.

In development, wound healing, and cancer metastasis, vertebrate cells move through 3D interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell front has been extensively studied, but the retraction phase of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ecf57988a8e0cacac4ed3494b50ae6
https://doi.org/10.2139/ssrn.3249468

Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion

Autor: Jean-Marc Schwartz, Joseph H. R. Hetmanski, Patrick T. Caswell

Publikováno v: Hetmanski, J, Schwartz, J-M & Caswell, P 2016, ' Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion ', Biochemical Society Transactions, vol. 44, no. 6, pp. 1695-1700 . https://doi.org/10.1042/BST20160184
Biochemical Society Transactions

Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro, all of which depend on Rho GTPases at some level. While traditional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96476cdee8db84704fadc71c5706d37f
https://www.research.manchester.ac.uk/portal/en/publications/modelling-gtpase-dynamics-to-understand-rhoadriven-cancer-cell-invasion(d23656dd-1619-4442-a926-c912eb720a27).html