Výsledky vyhledávání - "Joseph H. Porter"

Akademický článek

Vortioxetine Differentially Modulates MK-801-Induced Changes in Visual Signal Detection Task Performance and Locomotor Activity

Autor: Todd M. Hillhouse, Christina R. Merritt, Douglas A. Smith, Manuel Cajina, Connie Sanchez, Joseph H. Porter, Alan L. Pehrson

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Attention impairment is a common feature of Major Depressive Disorder (MDD), and MDD-associated cognitive dysfunction may play an important role in determining functional status among this patient population. Vortioxetine is a multimodal antidepressa

Externí odkaz: https://doaj.org/article/084468889a0a4ae09969c2ddabed7b72

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Akademický článek

Effects of (2R,6R)-hydroxynorketamine in assays of acute pain-stimulated and pain-depressed behaviors in mice.

Autor: Todd M Hillhouse, Kaitlyn J Partridge, Patrick I Garrett, Sarah C Honeycutt, Joseph H Porter

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0301848 (2024)

Ketamine has been shown to produce analgesia in various acute and chronic pain states; however, abuse liability concerns have limited its utility. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has been shown to produce antidepressant-like

Externí odkaz: https://doaj.org/article/1bc94511a1634c1eb7b0738d84a673d3

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How to account for hallucinations in the interpretation of the antidepressant effects of psychedelics: a translational framework

Autor: Manon van den Berg, Igor Magaraggia, Rudy Schreiber, Todd M. Hillhouse, Joseph H. Porter

Publikováno v: Psychopharmacology, 239(6), 1853-1879. Springer

Rationale Recent trials with psychedelics in major depressive disorder and treatment-resistant depression showed remarkable improvements in depressive symptoms that can last for up to several months after even a single administration. The lack of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45776b01516593a199bab2007e965cf1
https://cris.maastrichtuniversity.nl/en/publications/d6962d9d-89c7-4d4c-9029-e929923566cb

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Preliminary assessment of the subjective effects of electronic-cigarettes in young-adult low-dose electronic-cigarette users: Effects of nicotine dose and e-liquid flavor

Autor: Joseph H. Porter, Julia Blumenstein, James T Cooper, Carson T Clark, Cayla J Lynch, Rodney A. Hansen, Noah Gelfman, Todd M. Hillhouse, Makenzie L Peterson

Publikováno v: Journal of American college health : J of ACH.

Objective The present study evaluated the effects of nicotine concentration (0-10 mg/ml) and flavor (gummy bear vs unflavored) on the subjective experiences of vaporized nicotine in young adult low-dose nicotine (3 mg/ml) ECIG users. Participants Eig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9ca86e7a93d56938bec80dc39d245d
https://pubmed.ncbi.nlm.nih.gov/34283707

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Opioid receptor system contributes to the acute and sustained antidepressant-like effects, but not the hyperactivity motor effects of ketamine in mice

Autor: Joseph H. Porter, Todd M. Hillhouse, Taylor N. Kegen, Fan Zhang, Elizabeth Pottanat, Paige M. Anderson, Madeline Van Fossen, Peyton O. Koppenhaver, Sofia G. Manicka, Remington Rice, Jackson T. Lane

Publikováno v: Pharmacology, biochemistry, and behavior. 208

In 2000, a subanesthetic dose (0.5 mg/kg i.v.) of the dissociative anesthetic ketamine was reported to have both rapid and robust antidepressant effects in patients diagnosed with major depressive disorder and later, ketamine also was shown to be eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9056305209d8e6d525682ff0b670fb53
https://pubmed.ncbi.nlm.nih.gov/34224734

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Effects of subanesthetic ketamine and (2R,6R) hydroxynorketamine on working memory and synaptic transmission in the nucleus reuniens in mice

Autor: Priyodarshan Goswamee, Remington Rice, Elizabeth Leggett, Fan Zhang, Sofia Manicka, Joseph H. Porter, A. Rory McQuiston

Publikováno v: Neuropharmacology

Acute cognitive impairment and abuse potential of ketamine incentivizes the search for alternatives to ketamine for clinical management of treatment-resistant depression. Recently, (2R,6R) hydroxynorketamine ((2R,6R)-HNK), a metabolite of ketamine, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69c2a0d462a3d898442edf60b95634b
https://doi.org/10.1016/j.neuropharm.2022.108965

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Discriminative stimulus properties of the typical antipsychotic haloperidol compared to other antipsychotic drugs in C57BL/6 mice

Autor: Timothy J. Donahue, Kevin A. Webster, Eliseu O. De Oliveira, Todd M. Hillhouse, Joseph H. Porter

Publikováno v: Behavioural pharmacology. 30(6)

Haloperidol (HAL) was developed in 1958 for the treatment of schizophrenia and is classified as a typical antipsychotic drug (APD). Effective in treating positive symptoms of schizophrenia, it does not treat negative symptoms and produces extrapyrami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb23a3a2f9f9abf25845928119aa65cd
https://pubmed.ncbi.nlm.nih.gov/31058657

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