A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model

Autor: Lisa M. Plitnick, Beth Hutchins, Sheri Dubey, Nianyu Li, Rupesh P. Amin, Stephanie Born, Ruban Mangadu, Joseph H. Phillips, Venkataraman Sriram, Danuta J. Herzyk

Publikováno v: Journal of Immunotoxicology, Vol 17, Iss 1, Pp 175-185 (2020)

The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective human

Externí odkaz: https://doaj.org/article/2b47def718a34f4fad7a7bc77b84c7e9

The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production.

Autor: Cristina M Tato, Barbara Joyce-Shaikh, Antara Banerjee, Yi Chen, Manjiri Sathe, Sarah E Ewald, Man-Ru Liu, Daniel Gorman, Terrill K McClanahan, Joseph H Phillips, Paul G Heyworth, Daniel J Cua

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e31680 (2012)

Paired immunoglobulin-like receptors beta, PILRβ, and alpha, PILRα, are related to the Siglec family of receptors and are expressed primarily on cells of the myeloid lineage. PILRβ is a DAP12 binding partner expressed on both human and mouse myelo

Externí odkaz: https://doaj.org/article/7dd2bc5d727840dcb49554716f36855f

Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA

Autor: Stefan, Bauer, Veronika, Groh, Jun, Wu, Alexander, Steinle, Joseph H, Phillips, Lewis L, Lanier, Thomas, Spies

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 200(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d308d39208d3b59d3ac0b28c1a1d463
https://pubmed.ncbi.nlm.nih.gov/29555676

Cancer-induced Expansion and Activation of CD11b(+)Gr-1(+) Cells Predispose Mice to Adenoviral-triggered Anaphylactoid-type Reactions

Autor: Drake LaFace, Nico van Rooijen, Elena Brin, James E. Talmadge, Matthew J. Delano, Todd Machemer, Van Tsai, Manjiri Sathe, Terrill K. McClanahan, Kalyan Pande, Lyle L. Moldawer, Joseph H. Phillips, Roanna Ueda

Publikováno v: Molecular Therapy, 17(3), 508-515. Nature Publishing Group
Pande, K, Ueda, R, Machemer, T, Sathe, M, Tsai, V, Brin, E, Delano, M J, van Rooijen, N, McClanahan, T K, Talmadge, J E, Moldawer, L L, Phillips, J R & Laface, D M 2009, ' Cancer-induced Expansion and Activation of CD11b(+)Gr-1(+) Cells Predispose Mice to Adenoviral-triggered Anaphylactoid-type Reactions ', Molecular Therapy, vol. 17, no. 3, pp. 508-515 . https://doi.org/10.1038/mt.2008.280

Intravascular delivery (1.5 x 10(9) particles and higher) of recombinant adenovirus (rAd) induces myeloid cell mediated, self-limiting hemodynamic responses in normal mice. However, we observed anaphylactoid-type reactions and exacerbated hemodynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b5cbc77495bbf68c49787c05462abb
https://doi.org/10.1038/mt.2008.280

Monoclonal Antibody-Mediated CD200 Receptor Signaling Suppresses Macrophage Activation and Tissue Damage in Experimental Autoimmune Uveoretinitis

Autor: Holly Cherwinski, David A. Copland, Ben J. E. Raveney, Andrew D. Dick, Jonathon D. Sedgwick, Maria C. Jenmalm, Joseph H. Phillips, Claudia J. Calder, Lindsay B. Nicholson

Publikováno v: The American Journal of Pathology. 171:580-588

Macrophage responses are regulated by multiple secreted factors as well as by cell surface receptors, including the inhibitory signals resulting from ligation of myeloid CD200 receptors (CD200R) by the widely distributed CD200. In the absence of CD20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1064ef15020300fb77ccbbda00c4a1d9
https://doi.org/10.2353/ajpath.2007.070272