Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model

Autor: Chad K. Porter, David R. Tribble, Barbara DeNearing, Stephen J. Savarino, Robin McKenzie, Shannon L. Grahek, Aisling O'Dowd, Stephanie A. Sincock, Carl Brinkley, Steven T. Poole, Joseph H. Crabb, Colleen M. Woods, A. Louis Bourgeois, Hye Kim

Publikováno v: The Journal of Infectious Diseases. 220:505-513

BackgroundEnterotoxigenic Escherichia coli (ETEC) commonly cause diarrhea in children living in developing countries and in travelers to those regions. ETEC are characterized by colonization factors (CFs) that mediate intestinal adherence. We assesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ba8c78046f3ca0b5d4b1fa87d5a2b1
https://doi.org/10.1093/infdis/jiz135

Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial

Autor: Chad K. Porter, Stephanie A. Sincock, Stephen J. Savarino, Joseph H. Crabb, Shannon L. Grahek, Colleen M. Woods, Joyce A. Cantrell, David R. Tribble, Robin McKenzie, A. Louis Bourgeois, Aisling O'Dowd, Carl Brinkley, Barbara DeNearing, Hye Kim, Steven T. Poole

Publikováno v: The Journal of Infectious Diseases. 216:7-13

Background Tip-localized adhesive proteins of bacterial fimbriae from diverse pathogens confer protection in animal models, but efficacy in humans has not been reported. Enterotoxigenic Escherichia coli (ETEC) commonly elaborate colonization factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81377596315eca3e67ec4638f76da79e
https://doi.org/10.1093/infdis/jix144

Maternal vaccination with a fimbrial tip adhesin and passive protection of neonatal mice against lethal human enterotoxigenic Escherichia coli challenge

Autor: Wilson Barros Luiz, Luís Carlos de Souza Ferreira, Stephen J. Savarino, Juliana F. Rodrigues, Joseph H. Crabb

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Globally, enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers' diarrhea, for which an effective vaccine is needed. Prevalent intestinal colonization factors (CFs) such as CFA/I fimbriae and heat-labile enterotoxin (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92323eced92e25060aecafda1827da8
https://pubmed.ncbi.nlm.nih.gov/26371126

Milk Immunoglobulin with Specific Activity against Purified Colonization Factor Antigens Can Protect against Oral Challenge with EnterotoxigenicEscherichia coli

Autor: Carol O. Tacket, Ann Delehanty, David R. Maneval, James P. Nataro, Daniel J. Freedman, Joseph H. Crabb

Publikováno v: The Journal of Infectious Diseases. 177:662-667

Enterotoxigenic Escherichia coli (ETEC) is the most commonly isolated pathogen responsible for travelers' diarrhea and the cause of up to 650 million cases of pediatric diarrhea per year in the developing world. As a safe alternative to the prophylac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727d571d81ecc41324d64ec8b9574e10
https://doi.org/10.1086/514227

Water-borne Cryptosporidiosis: Detection Methods and Treatment Options

Autor: Colin R. Fricker, Joseph H. Crabb

Publikováno v: Advances in Parasitology. 40:241-278

Since the infamous outbreak in Milwaukee, WI, USA, of water-borne cryptosporidiosis affecting over 400,000 people, there have been at least 20 smaller outbreaks associated with this parasite in the UK and North America. These events have led to an ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb187d1b1791e097a60e154860a48053
https://doi.org/10.1016/s0065-308x(08)60123-2