Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joseph H Lubin"'
Autor:
Nancy E. Hernandez, Wojciech Jankowski, Rahel Frick, Simon P. Kelow, Joseph H. Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D. Khare, Roland L. Dunbrack, Jr., Jeffrey J. Gray, Zuben E. Sauna
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e17901- (2023)
Externí odkaz:
https://doaj.org/article/9e85b30d52f24dc1a21cd1acfeca00cb
Autor:
Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Minh T. Ma, Chih-Hsiung Chen, Dongfang Liu, Renata Pasqualini, Wadih Arap, Stephen K. Burley, Sagar D. Khare
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Given the COVID-19 pandemic, there is interest in understanding ligand-receptor features and targeted antibody-binding attributes against emerging SARS-CoV-2 variants. Here, we developed a large-scale structure-based pipeline for analysis of protein-
Externí odkaz:
https://doaj.org/article/dc31889fa8f7403f837661ab04c09d04
Autor:
Nancy E. Hernandez, Wojciech Jankowski, Rahel Frick, Simon P. Kelow, Joseph H. Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D. Khare, Roland L. Dunbrack, Jr., Jeffrey J. Gray, Zuben E. Sauna
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15032- (2023)
The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred prophylactic response to epidemics and pandemics. However, for individuals who have contract
Externí odkaz:
https://doaj.org/article/ce94e33881824004b4d691d4ee80fb5c
Autor:
Changpeng Lu, Joseph H. Lubin, Vidur V. Sarma, Samuel Z. Stentz, Guanyang Wang, Sijian Wang, Sagar D. Khare
Specific molecular recognition of substrates by enzymes, e.g., proteases, is critical for maintaining the robustness of crucial life processes. The ability to predictably tailor protease specificity would enable targeted proteolytic cleavage of any c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5c32099fa12647d4cdfd881c3dc95
Autor:
Changpeng Lu, Joseph H. Lubin, Vidur V. Sarma, Samuel Z. Stentz, Guanyang Wang, Sijian Wang, Sagar D. Khare
Publikováno v:
bioRxiv
Site-specific proteolysis by the enzymatic cleavage of small linear sequence motifs is a key post-translational modification involved in physiology and disease. The ability to robustly and rapidly predict protease substrate specificity would also ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718540de64658369aa37a0439feef3af
https://doi.org/10.1101/2023.02.16.528728
https://doi.org/10.1101/2023.02.16.528728
Autor:
Joseph H. Lubin, Samantha G. Martinusen, Christine Zardecki, Cassandra Olivas, Mickayla Bacorn, MaryAgnes Balogun, Ethan W. Slaton, Amy Wu Wu, Sarah Sakeer, Brian P. Hudson, Carl A. Denard, Stephen K. Burley, Sagar D. Khare
Although the rapid development of therapeutic responses to combat SARS-CoV-2 represents a great human achievement, it also demonstrates untapped potential for advanced pandemic preparedness. Cross-species efficacy against multiple human coronaviruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6006e16589029f5671c4655a50578fa
https://doi.org/10.1101/2023.01.30.526101
https://doi.org/10.1101/2023.01.30.526101
Autor:
Charlotte Labrie-Cleary, Jitendra Singh, Steven Arnold, Andrew Sam, Mark Dresel, Luz Helena Alfaro Alvarado, Rebecca Roberts, Emily Fingar, Jennifer Jiang, Paul Craig, Jean Baum, Eddy Arnold, Christine Zardecki, Grace Brannigan, Julia R. Koeppe, Elizabeth M Hennen, Alan Trudeau, Joseph H Lubin, Thejasvi Venkatachalam, Jonathan K. Williams, Kevin Catalfano, Stephen K. Burley, Brian P. Hudson, Isaac Paredes, Sagar D. Khare, Yana Bromberg, Katherine See, Evan Lenkeit, Shuchismita Dutta, J. Steen Hoyer, Erika McCarthy, Michael J. Pikaart, Santiago Soto Zapata, Jenna Currier, Stephanie Laporte, Jay A. Tischfield, Siobain Duffy, Britney Dyszel, Maria Voigt, Changpeng Lu, Bonnie L. Hall, Jesse Sandberg, Kailey Martin, Aaliyah Khan, Stephen A. Mills, Sophia Staggers, Allison Rupert, Elliott M Dolan, Vidur Sarma, Lindsey Whitmore, Helen Zheng, Ashish Duvvuru, David S. Goodsell, Michael Kirsch, Melanie Ortiz-Alvarez de la Campa, Ali A Khan, Matthew Benedek, Francesc X. Ruiz, John D. Westbrook, Marilyn Orellana, Lingjun Xie, Zhuofan Shen, Baleigh Wheeler, Brea Tinsley
Publikováno v:
Proteins
bioRxiv
bioRxiv
Three-dimensional structures of SARS-CoV-2 and other coronaviral proteins archived in the Protein Data Bank were used to analyze viral proteome evolution during the first six months of the COVID-19 pandemic. Analyses of spatial locations, chemical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184f799ef7472866dc4aa3149ef49eaf
https://doi.org/10.1002/prot.26250
https://doi.org/10.1002/prot.26250
Autor:
Amy Wu Wu, Joseph H. Lubin, Cassandra Olivas, Christine Zardecki, MaryAgnes Balogun, Mickayla L. Bacorn, Sagar D. Khare, Stephen K. Burley
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8c9c9fc5d26dc907037fb26a0315b1f
https://doi.org/10.1096/fasebj.2022.36.s1.0r729
https://doi.org/10.1096/fasebj.2022.36.s1.0r729
Autor:
Christopher Markosian, Daniela I. Staquicini, Prashant Dogra, Esteban Dodero-Rojas, Joseph H. Lubin, Fenny H.F. Tang, Tracey L. Smith, Vinícius G. Contessoto, Steven K. Libutti, Zhihui Wang, Vittorio Cristini, Sagar D. Khare, Paul C. Whitford, Stephen K. Burley, José N. Onuchic, Renata Pasqualini, Wadih Arap
Publikováno v:
Molecular Biology and Evolution. 39
Evaluation of immunogenic epitopes for universal vaccine development in the face of ongoing SARS-CoV-2 evolution remains a challenge. Herein, we investigate the genetic and structural conservation of an immunogenically relevant epitope (C662–C671)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac5e1c4bd4b0159c18d771da585e9a1d
https://doi.org/10.1093/molbev/msac091
https://doi.org/10.1093/molbev/msac091