Výsledky vyhledávání - "Joseph H, Steinbach"

Reduced Activation of the Synaptic-Type GABAA Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization

Autor: Allison L. Germann, Gustav Akk, Joseph H. Steinbach, Alex S. Evers, Spencer R. Pierce

Publikováno v: Molecular Pharmacology. 98:762-769

Synaptic GABAA receptors are alternately exposed to short pulses of a high, millimolar concentration of GABA and prolonged periods of low, micromolar concentration of the transmitter. Prior work has indicated that exposure to micromolar concentration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b97417978c74f38793c89e74fd111b0
https://doi.org/10.1124/molpharm.120.000088

Zobrazit plný text záznamu

The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABA(A) Receptor by Stabilizing a Novel Nonconducting State

Autor: Gustav Akk, Spencer R. Pierce, Joseph H. Steinbach, Allison L. Germann

Publikováno v: Mol Pharmacol

The γ-aminobutyric acid type A (GABAA) receptor is inhibited by the endogenous sulfated steroids pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS). It has been proposed in previous work that these steroids act by enhancing desensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abde14526eb3129a231f3962e767351
https://europepmc.org/articles/PMC8969134/

Zobrazit plný text záznamu

Akademický článek

A phylogenetic survey of biliary lipids in vertebrates1

Autor: Antonio Moschetta, Fang Xu, Lee R. Hagey, Gerard P. van Berge-Henegouwen, Karel J. van Erpecum, Jos F. Brouwers, Jonathan C. Cohen, Molly Bierman, Helen H. Hobbs, Joseph H. Steinbach, Alan F. Hofmann

Publikováno v: Journal of Lipid Research, Vol 46, Iss 10, Pp 2221-2232 (2005)

Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples

Externí odkaz: https://doaj.org/article/9632bad0da344203aa3682930e347105

Zobrazit plný text záznamu

Intrasubunit and intersubunit steroid binding sites independently and additively mediate α1β2γ2L GABAA receptor potentiation by the endogenous neurosteroid allopregnanolone

Autor: Joseph H. Steinbach, Alex S. Evers, Gustav Akk, Spencer R. Pierce, Yusuke Sugasawa, Hiroki Tateiwa, David E. Reichert, Allison L. Germann

Publikováno v: Molecular Pharmacology. :MOLPHARM-AR

Prior work employing functional analysis, photolabeling, and X-ray crystallography have identified three distinct binding sites for potentiating steroids in the heteromeric GABAA receptor. The sites are located in the membrane-spanning domains of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be0526de62930c636c69e1fee70aed4
https://doi.org/10.1124/molpharm.121.000268

Zobrazit plný text záznamu

Enhancement of muscimol binding and gating by allosteric modulators of the GABAA receptor: relating occupancy to state functions

Autor: Joseph H. Steinbach, Yusuke Sugasawa, Spencer R. Pierce, Alex S. Evers, Gustav Akk, Allison L. Germann

Publikováno v: Molecular Pharmacology. :MOLPHARM-AR

Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria and a potent orthosteric agonist of the GABAA receptor. The binding of [3H]muscimol has been used to evaluate the distribution of GABAA receptors in the brain, and studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9041704a3394354973f2c59393a8d9fd
https://doi.org/10.1124/molpharm.120.000066

Zobrazit plný text záznamu

The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAAreceptors

Autor: Alex S. Evers, Brad D. Manion, John Bracamontes, Ping Li, Joseph H. Steinbach, Gustav Akk, Steven Mennerick

Publikováno v: British Journal of Pharmacology. 171:5446-5457

Background and Purpose Neurosteroids potentiate responses of the GABAA receptor to the endogenous agonist GABA. Here, we examined the ability of neurosteroids to potentiate responses to the allosteric activators etomidate, pentobarbital and propofol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::889b9808004a8fe432bf3173cc856b79
https://doi.org/10.1111/bph.12861

Zobrazit plný text záznamu

Plný text ve formátu HTML

Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions

Autor: H-J Shu, Joseph H. Steinbach, Steven Mennerick, Mariangela Chisari, Charles F. Zorumski, Amanda Taylor

Publikováno v: British Journal of Pharmacology. 160:130-141

Background and purpose: Some neurosteroids, notably 3α-hydroxysteroids, positively modulate GABAA receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44adbfd6f83b8924d135c7a3d38d6297
https://doi.org/10.1111/j.1476-5381.2010.00679.x

Zobrazit plný text záznamu

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

Autor: Anthony L. Hinrichs, Lingwei Sun, Richard A. Grucza, Jen C. Wang, Naomi Breslau, Alison Goate, Louis Fox, Meng Wu, Dorothy K. Hatsukami, Laura J. Bierut, Robert Culverhouse, Joseph H. Steinbach, John P. Budde, Nancy L. Saccone, Scott F. Saccone, John P. Rice, Eric O. Johnson, Weimin Duan

Publikováno v: Cancer Research. 69:6848-6856

Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine dependence, smoking, and lung cancer in populations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df58f769c05d2902b37baafad0c58e58
https://doi.org/10.1158/0008-5472.can-09-0786

Zobrazit plný text záznamu

Altered Bile Acid Metabolism in Childhood Functional Constipation: Inactivation of Secretory Bile Acids by Sulfation in a Subset of Patients

Autor: Alan F. Hofmann, Lee R. Hagey, Dale A. Chatfield, Terrance L. Griffin, Vera Loening-Baucke, Joel E. Lavine, Christine A. Packard, Joseph H. Steinbach

Publikováno v: Journal of Pediatric Gastroenterology & Nutrition. 47:598-606

An elevated concentration in the colon of the primary bile acid chenodeoxycholic acid (CDCA) or the secondary bile acid deoxycholic acid (DCA) is known to induce water secretion, causing diarrhea. We hypothesized that of the many fecal bile acids, on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155047f0f04e6377a865dbb15a19d8d3
https://doi.org/10.1097/mpg.0b013e31816920a6

Zobrazit plný text záznamu

Mechanisms of potentiation of the mammalian GABAAreceptor by the marine cembranoid eupalmerin acetate

Autor: Joseph H. Steinbach, A D Rodríguez, Ping Li, Brad D. Manion, Vesna A. Eterovic, Alex S. Evers, David E. Reichert, Gustav Akk

Publikováno v: British Journal of Pharmacology. 153:598-608

Background and purpose: Eupalmerin acetate (EPA) is a marine diterpene compound isolated from the gorgonian octocorals Eunicea succinea and Eunicea mammosa. The compound has been previously shown to modulate muscle-type and neuronal nicotinic acetylc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3b268a3dc2c38a64998b766b455b245
https://doi.org/10.1038/sj.bjp.0707597

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání