Zobrazeno 1 - 10
of 494
pro vyhledávání: '"Joseph H, Lee"'
Autor:
Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-McHale, Deborah Pang, Lisa Melilli, Sid O'Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Howard J. Aizenstein, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus Birn, Adam M. Brickman, Peter Bulova, Amrita Cheema, Kewei Chen, Bradley T. Christian, Isabel Clare, Lorraine Clark, Ann D. Cohen, John N. Constantino, Eric W. Doran, Anne Fagan, Eleanor Feingold, Tatiana M. Foroud, Benjamin L. Handen, Jordan Harp, Sigan L. Hartley, Rachel Henson, Lawrence Honig, Milos D. Ikonomovic, Sterling C. Johnson, Courtney Jordan, M.Ilyas Kamboh, David Keator, William E. Klunk, Julia K. Kofler, William Charles Kreisl, Sharon J. Krinsky-McHale, Patrick Lao, Ira T. Lott, Victoria Lupson, Chester A. Mathis, Davneet Singh Minhas, Neelesh Nadkarni, Sid O’Bryant, Melisa Parisi, Melissa Pettersen, Julie C. Price, Margaret Pulsifer, Michael S. Rafii, Eric Reiman, Batool Rizvi, Laurie Ryan, Frederick Schmitt, Wayne P. Silverman, Dana L. Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A. White, Michael A. Yassa, Fan Zhang
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105433- (2024)
Summary: Background: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this
Externí odkaz:
https://doaj.org/article/7bcbc45f9a5e40b7ab0502504ef1c084
Autor:
Emily K. Schworer, Benjamin L. Handen, Melissa Petersen, Sid O'Bryant, Jamie C. Peven, Dana L. Tudorascu, Laisze Lee, Sharon J. Krinsky‐McHale, Christy L. Hom, Isabel C. H. Clare, Bradley T. Christian, Nicole Schupf, Joseph H. Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M. Ances, Shahid Zaman, Adam M. Brickman, Florence Lai, H. Diana Rosas, Sigan L. Hartley, the Alzheimer Biomarker Consortium‐Down Syndrome
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of A
Externí odkaz:
https://doaj.org/article/13dbf3a21419485bb2909612d2c5af23
Autor:
Aigul Sharip, Saule Rakhimova, Askhat Molkenov, Ainur Ashenova, Ulan Kozhamkulov, Ilyas Akhmetollayev, Andrei Zinovyev, Yuri Zhukov, Marat Omarov, Mukhtar Tuleutaev, Venera Rakhmetova, Joseph D. Terwilliger, Joseph H. Lee, Zhaxybay Zhumadilov, Ainur Akilzhanova, Ulykbek Kairov
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer in Central Asia, often diagnosed at advanced stages. Understanding population-specific patterns of ESCC is crucial for tailored treatments. This study aimed to
Externí odkaz:
https://doaj.org/article/8d93a8a4fba9434a8c658350af07c25d
Autor:
Tracy A. Listwan, Sharon J. Krinsky‐McHale, Cynthia M. Kovacs, Joseph H. Lee, Deborah I. Pang, Nicole Schupf, Benjamin Tycko, Warren B. Zigman, Wayne Silverman
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Alzheimer's disease (AD) affecting adults with Down syndrome (DS‐AD), like late‐onset AD (LOAD) in the neurotypical population, has preclinical, prodromal, and more advanced stages. Only tasks placing high demands on cogniti
Externí odkaz:
https://doaj.org/article/8a32287c92f44e74bb715683cc9a21f6
Autor:
Jacinda Chen, Rajesh Kumar Soni, Yimeng Xu, Sabrina Simoes, Feng-Xia Liang, Laura DeFreitas, Robert Hwang, Jr., Jorge Montesinos, Joseph H. Lee, Estela Area-Gomez, Renu Nandakumar, Badri Vardarajan, Catherine Marquer
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104628- (2023)
Summary: Background: The most common form of neuronal ceroid lipofuscinosis (NCL) is juvenile CLN3 disease (JNCL), a currently incurable neurodegenerative disorder caused by mutations in the CLN3 gene. Based on our previous work and on the premise th
Externí odkaz:
https://doaj.org/article/7c799b4b21b24ad59d3201ed5f5b8cc6
Autor:
Wayne Silverman, Sharon J. Krinsky‐McHale, Cynthia Kovacs, Joseph H. Lee, Tracy Listwan, Deborah I. Pang, Warren B. Zigman, Nicole Schupf
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Introduction Adults with Down syndrome (DS) are at increased risk for Alzheimer's disease (AD) and vary in their age of transition from AD preclinical to prodromal or more advanced clinical stages. An empirically based method is needed to de
Externí odkaz:
https://doaj.org/article/b6af2015574f46abaf1715745275ea3c
Autor:
Ulykbek Kairov, Askhat Molkenov, Aigul Sharip, Saule Rakhimova, Madina Seidualy, Arang Rhie, Ulan Kozhamkulov, Maxat Zhabagin, Jong-Il Kim, Joseph H. Lee, Joseph D. Terwilliger, Jeong-Sun Seo, Zhaxybay Zhumadilov, Ainur Akilzhanova
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Kazakhstan, the ninth-largest country in the world, is located along the Great Silk Road and connects Europe with Asia. Historically, its territory has been inhabited by nomadic tribes, and modern-day Kazakhstan is a multiethnic country with a domina
Externí odkaz:
https://doaj.org/article/9cbd4931979e489eb8c3c89d16266f20
Autor:
Jesus D. Melgarejo, Gladys E. Maestre, Jose Gutierrez, Lutgarde Thijs, Luis J. Mena, Ciro Gaona, Reinier Leendertz, Joseph H. Lee, Carlos A. Chávez, Gustavo Calmon, Egle Silva, Dongmei Wei, Joseph D. Terwilliger, Thomas Vanassche, Stefan Janssens, Peter Verhamme, Daniel Bos, Zhen-Yu Zhang
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundTwenty-four-hour and nighttime blood pressure (BP) levels are more strongly associated with cardiovascular risk than office or daytime BP measurements. However, it remains undocumented which of the office and ambulatory BP measurements have
Externí odkaz:
https://doaj.org/article/683136cf100642b78681dc8e264e9329
Autor:
Gladys E. Maestre, Rosa V. Pirela, Carmen L. Paz, Jesus D. Melgarejo, Luis J. Mena, Carlos A. Chavez, Reinier Leendertz, Michele Petitto, Eglé Silva, Gustavo E. Calmón, Lama Al-Aswad, Joseph H. Lee, Joseph D. Terwilliger
Publikováno v:
BMC Public Health, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Venezuela is in the throes of a complex humanitarian crisis that is one of the worst in decades to impact any country outside of wartime. This case analysis describes the challenges faced by the ongoing Maracaibo Aging Study (MAS)
Externí odkaz:
https://doaj.org/article/8365f0762be946e1b5eb14eeb4f438dd
Autor:
Paige Carlson, Mary K. Wojczynski, Todd Druley, Joseph H. Lee, Joseph M. Zmuda, Bharat Thyagarajan
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-7 (2020)
Abstract Background Phenotypic expression of pathogenic variants in individuals with no family history of inherited disorders remains unclear. Methods We evaluated the prevalence of pathogenic variants in 25 genes associated with Mendelian-inherited
Externí odkaz:
https://doaj.org/article/deb533c9994d491797fae10481fedead