Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joseph Gunnet"'
Autor:
Raul C. Camacho, Seohee You, Katharine E. D’Aquino, Wenyu Li, Yuanping Wang, Joseph Gunnet, James Littrell, Jian Shen Qi, Lijuan Kang, Wenying Jian, Mary MacDonald, Timothy Tat, Derek Steiner, Yue-Mei Zhang, James Lanter, Raymond Patch, Rui Zhang, Jiali Li, Suzanne Edavettal, Wilson Edwards, Thai Dinh, Li Ying Wang, Judy Connor, Michael Hunter, Ellen Chi, Ronald V. Swanson, James N. Leonard, Martin A. Case
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The long circulating half-life and inherently bivalent architecture of IgGs provide an ideal vehicle for presenting otherwise short-lived G-protein-coupled receptor agonists in a format that enables avidity-driven enhancement of potency. Here, we des
Externí odkaz:
https://doaj.org/article/5eb7ffd685414dc1807d86d35890f6a4
Autor:
Jian Shen Qi, Thai Dinh, Timothy Tat, James Littrell, Ronald V. Swanson, Raul C. Camacho, Mary MacDonald, Ellen Chi, Lijuan Kang, Derek Steiner, Katharine D'Aquino, Jiali Li, Wenying Jian, Yue-Mei Zhang, James N. Leonard, Li Ying Wang, Yuanping Wang, Suzanne Edavettal, Michael J. Hunter, Wenyu Li, Case Martin A, Joseph Gunnet, Raymond J. Patch, Seohee You, Judy Connor, Wilson Edwards, Zhang Rui, James C. Lanter
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The long circulating half-life and inherently bivalent architecture of IgGs provide an ideal vehicle for presenting otherwise short-lived G-protein-coupled receptor agonists in a format that enables avidity-driven enhancement of potency. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c0ad01619c709ccaefd8edf1de67f3
https://doi.org/10.1080/19420862.2020.1794687
https://doi.org/10.1080/19420862.2020.1794687
Autor:
Zhihua Sui, William V. Murray, Celia Jenkinson, Norman D. Huebert, Peter Haug, Michael P. Winters, Wen Yan, James N. Leonard, Yuanping Wang, Arthur T. Suckow, Austin Bell, Tatiana Koudriakova, Hong Hua, Wilmelenne Clapper, Wall Mark, Joseph Gunnet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:841-846
The discovery of a novel series of N-arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4c10129d3f5497d09467dc3e434527
https://doi.org/10.1016/j.bmcl.2018.02.013
https://doi.org/10.1016/j.bmcl.2018.02.013
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists
Autor:
Austin Bell, Hong Hua, Wen Yan, Chaozhong Cai, Celia Jenkinson, Peter Haug, Wall Mark, Yuanping Wang, Imad Nashashibi, Xuqing Zhang, Arthur T. Suckow, Michael P. Winters, James N. Leonard, Michele Wells, Joseph Gunnet, William V. Murray, Zhihua Sui, Jingyuan Ma, James C. Lanter, Wilma Clapper, Aaron Novack
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3272-3278
A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c99a9954f694ac0a6035dcb18ac83bf
https://doi.org/10.1016/j.bmcl.2017.06.028
https://doi.org/10.1016/j.bmcl.2017.06.028
Autor:
Wall Mark, Celia Jenkinson, Zhihua Sui, Michael P. Winters, Tatiana Koudriakova, Norman D. Huebert, James N. Leonard, Yuanping Wang, Austin Bell, Hong Hua, Peter Haug, William V. Murray, Joseph Gunnet, Wilmelenne Clapper, Wen Yan, Arthur T. Suckow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1676-1678
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582d0fbc15d6cca0f7ef2a62b7166cbc
https://doi.org/10.1016/j.bmcl.2018.03.053
https://doi.org/10.1016/j.bmcl.2018.03.053
Autor:
Zhihua Sui, Yuanping Wang, Xuqing Zhang, Mark J. Macielag, Hong Hua, Wen Yan, Peter Haug, Austin Bell, Joseph Gunnet, Chaozhong Cai, Celia Jenkinson, William V. Murray, James N. Leonard, Arthur T. Suckow, Wilma Clapper
We have discovered a novel series of isothiazole-based phenylpropanoic acids as GPR120 agonists. Extensive structure–activity relationship studies led to the discovery of a potent GPR120 agonist 4x, which displayed good EC50 values in both calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ef3b314c5a726bc0646f755898f00a
https://europepmc.org/articles/PMC5601374/
https://europepmc.org/articles/PMC5601374/
