Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Joseph Gerrein"'
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Abstract A1-66: Leveraging Gene Expression in the Bronchial Airway to Develop a Nasal Biomarker for Early Detection of Lung Cancer
Autor: Teresa W. Wang, Joseph Gerrein, Avrum Spira, Rebecca Kusko, Duncan Whitney, Joshua D. Campbell, Joseph Perez-Rogers, Kate Porta, Marc E. Lenburg, Christina Anderlind
Publikováno v: Cancer Research. 75:A1-66
Rationale: Lung cancer results in five times more deaths per year than car accidents in the United States. Approximately 57% of lung cancers diagnosed this year will be diagnosed at a late stage and these patients will exhibit a 5-year survival rate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::724209ef56fb0e69755c84ddc0485c54
https://doi.org/10.1158/1538-7445.transcagen-a1-66
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2
Abstract B1-50: Leveraging gene expression in the bronchial airway to develop a nasal biomarker for early detection of lung cancer
Autor: Joseph F. Perez-Rogers, Joseph Gerrein, Christina Anderlind, Rebecca L. Kusko, Joshua D. Campbell, Teresa Wang, Kate Porta, Duncan Whitney, Avrum Spira, Marc Lenburg
Publikováno v: Cancer Research. 75:B1-50
Rationale: Lung cancer results in five times more deaths per year than car accidents in the United States. Approximately 57% of lung cancers diagnosed this year will be diagnosed at a late stage and these patients will exhibit a 5-year survival rate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65882a261ce4895cd627efbf00eadec4
https://doi.org/10.1158/1538-7445.compsysbio-b1-50
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3
Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data
Autor: John Quackenbush, Lingqi Luo, Brenda Juan-Guardela, John Tedrow, Avrum Spira, Joseph Gerrein, Jennifer Beane, Marc E. Lenburg, Joshua D. Campbell, David A. Schwartz, Stefano Monti, Ivana V. Yang, Yuriy O. Alekseyev, W. Evan Johnson, Frank C. Sciurba, Ji Xiao, Mark W. Geraci, Mick Correll, Naftali Kaminski, Gang Liu
Publikováno v: RNA. 21:164-171
Small RNA sequencing can be used to gain an unprecedented amount of detail into the microRNA transcriptome. The relatively high cost and low throughput of sequencing bases technologies can potentially be offset by the use of multiplexing. However, mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daec470e0219abe32b416e8cd9f70e3
https://doi.org/10.1261/rna.046060.114
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4
The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity
Autor: Rachel Peters, Joseph Gerrein, Alexa Meehan, Mary Carsillo, Hugues Bernard, Francis S. Wolenski, Erik Koenig, Patrick Kirby, Aimy Tse, Aaron Smith, Matt J. Gallacher, Stephen Tirrell, Craig Fisher
Publikováno v: BMC Genomics
Background MicroRNAs (miRNA) are varied in length, under 25 nucleotides, single-stranded noncoding RNA that regulate post-transcriptional gene expression via translational repression or mRNA degradation. Elevated levels of miRNAs can be detected in s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938905e46c68afe3f1ad1f0e05c21b9c
http://europepmc.org/articles/PMC4989286
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5
Rapid diagnosis of late-onset Pompe disease by fluorometric assay of α-glucosidase activities in dried blood spots
Autor: Robert J. Pomponio, Deyanira Corzo, Priya S. Kishnani, Joseph Gerrein, Deeksha Bali, Jian Dai, Joan Keutzer, Alison Skrinar, Mariah Titlow, Helmut Kallwass, Cortney Carr
Publikováno v: Molecular Genetics and Metabolism. 90:449-452
The enzymatic defect in Pompe disease is insufficient lysosomal acid alpha-glucosidase (GAA) activity which leads to lysosomal glycogen accumulation. We recently introduced a simple and reliable method to measure GAA activity in dried blood spots usi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37556952b241bfa731d14de3671806ff
https://doi.org/10.1016/j.ymgme.2006.12.006
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6
MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis
Autor: Christina Anderlind, Brigitte N. Gomperts, Marc E. Lenburg, Steven A. Belinsky, George R. Jackson, Huiqing Si, Carl O'Hara, Steven M. Dubinett, Tonya C. Walser, Joshua D. Campbell, Catalina Perdomo, Frank Schembri, Jessica Vick, Patrick Hayden, Adam C. Gower, Avrum Spira, Joseph Gerrein, Courtney Mankus, Eduard Drizik, Carmen S. Tellez, Carly B. Garrison
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 47
Perdomo, C; Campbell, JD; Gerrein, J; Tellez, CS; Garrison, CB; Walser, TC; et al.(2013). MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110(47), 18946-18951. doi: 10.1073/pnas.1220319110. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5rf0430k
Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. Although microRNAs are regulators of many airway gene-expression changes induced by smoking, their role in modulating changes associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9925672265f49c57c07584d190f34100
https://escholarship.org/uc/item/5rf0430k
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9
Abstract 1574: Leveraging bronchial airway gene expression to develop a nasal biomarker for lung cancer detection
Autor: Teresa Wang, Yuriy O. Alekseyev, Kate Porta, Rebecca Kusko, Joshua D. Campbell, Christina Anderlind, Avrum Spira, Joseph Perez-Rogers, Duncan Whitney, Gang Liu, Xiaohui Xiao, Joseph Gerrein, Hanqiao Liu, Marc E. Lenburg
Publikováno v: Cancer Research. 75:1574-1574
Rationale: Using nasal gene expression to predict the presence of lung cancer would offer a less invasive alternative to diagnostic approaches we have pioneered using bronchial airway epithelial (BE) gene expression. We have previously demonstrated t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa5cc8bc5364d21e99cf01a07c75f54c
https://doi.org/10.1158/1538-7445.am2015-1574
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10
Characterizing the small RNA transcriptome associated with COPD and ILD using next-generation sequencing
Autor: Mick Correll, John Tedrow, Joseph Gerrein, John Quackenbush, Lingqi Luo, Gang Liu, Ji Xiao, Jennifer Beane, Marc E. Lenburg, Brenda Juan Guardela, David A. Schwartz, Yuriy Aleksyev, Naftali Kaminski, Avrum Spira, Joshua D. Campbell, Frank C. Sciurba, Ivana V. Yang, Mark W. Geraci
Publikováno v: BMC Proceedings
Background Despite the increasing public health burden associated with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD), the molecular mechanisms responsible for the pathogenesis of these diseases remain unclear. The g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8f61bc61f35e0bed95d645043b708e
http://europepmc.org/articles/PMC3467555
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