Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Joseph Gera"'
Autor:
Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T. Saunders, Sunil Kumar, Robert N. Nishimura, Joseph Gera
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 951-965 (2021)
The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive characte
Externí odkaz:
https://doaj.org/article/b01e8986ccf741549a1fff9a968ce1fb
Autor:
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212160 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0176599.].
Externí odkaz:
https://doaj.org/article/6135fc6ac3384c2cb1bc61b7bb8498c8
Autor:
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176599 (2017)
A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen and evaluated as a potential inhibitor of mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID
Externí odkaz:
https://doaj.org/article/dfba5d1f920047d6a7daff473ec6327c
Autor:
Yijiang Shi, Patrick Frost, Bao Hoang, Yonghui Yang, Carolyne Bardeleben, Joseph Gera, Alan Lichtenstein
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94011 (2014)
Because multiple myeloma (MM) cells are at risk for endoplasmic reticulum (ER) stress, they require a carefully regulated mechanism to promote protein translation of selected transcripts when proliferation is stimulated. MAPK-interacting kinases (MNK
Externí odkaz:
https://doaj.org/article/afbb6a8ed1804a6b8aca5b065b7ec90c
Autor:
Tariq Bashir, Cheri Cloninger, Nicholas Artinian, Lauren Anderson, Andrew Bernath, Brent Holmes, Angelica Benavides-Serrato, Nesrin Sabha, Robert N Nishimura, Abhijit Guha, Joseph Gera
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47741 (2012)
Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive charac
Externí odkaz:
https://doaj.org/article/721fd34cf976430c8349f3a93c63e338
Autor:
Jacquelyn T. Saunders, Sunil Kumar, Angelica Benavides-Serrato, Brent Holmes, Kennedy E. Benavides, Muhammad T. Bashir, Robert N. Nishimura, Joseph Gera
Publikováno v:
Journal of Neuro-Oncology. 163:207-218
Introduction HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af1f1b527e20811fcb6f4bcd6e455df
https://doi.org/10.1007/s11060-023-04331-5
https://doi.org/10.1007/s11060-023-04331-5
Autor:
Chris Hino, Grace Chan, Gwen Jordaan, Sophia S. Chang, Jacquelyn T. Saunders, Mohammad T. Bashir, James E. Hansen, Joseph Gera, Richard H. Weisbart, Robert N. Nishimura
Publikováno v:
Cell Stress and Chaperones.
Heat shock proteins (HSPs), especially Hsp70 (HSPA1), have been associated with cellular protection from various cellular stresses including heat, hypoxia-ischemia, neurodegeneration, toxins, and trauma. Endogenous HSPs are often synthesized in direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5088e42a4fd95c0d30dfd168cdfab94
https://doi.org/10.1007/s12192-023-01349-6
https://doi.org/10.1007/s12192-023-01349-6
Autor:
Joseph Gera, Alan Lichtenstein, Janine Masri, Lauren Anderson, Teresa Ruegg, Nicholas Artinian, Brent Holmes, Tariq Bashir, Andrew Bernath, Cheri Cloninger
A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin, the prototypic mTORC1 inhibitor. Several studies have shown that the status of the AKT kinase plays a critical role in determining hypersensitivity. Cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ab69775d46fd3d83a1f2aad6c02274
https://doi.org/10.1158/1535-7163.c.6535204
https://doi.org/10.1158/1535-7163.c.6535204
Autor:
Joseph Gera, Alan Lichtenstein, Janine Masri, Lauren Anderson, Teresa Ruegg, Nicholas Artinian, Brent Holmes, Tariq Bashir, Andrew Bernath, Cheri Cloninger
PDF file 47K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6eaf1eb24ca5e973f664e6e0800cba
https://doi.org/10.1158/1535-7163.22496245
https://doi.org/10.1158/1535-7163.22496245
Autor:
Joseph Gera, Alan Lichtenstein, Janine Masri, Lauren Anderson, Teresa Ruegg, Nicholas Artinian, Brent Holmes, Tariq Bashir, Andrew Bernath, Cheri Cloninger
PDF file - 520K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d088a57decd2cbe48a4891d5cbb864
https://doi.org/10.1158/1535-7163.22496248
https://doi.org/10.1158/1535-7163.22496248