Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joseph Gawron"'
Publikováno v:
PLoS ONE, Vol 19, Iss 12, p e0314858 (2024)
Krabbe disease (Kd) is a lysosomal storage disorder (LSD) caused by the deficiency of the lysosomal galactosylceramidase (GALC) which cleaves the myelin enriched lipid galactosylceramide (GalCer). Accumulated GalCer is catabolized into the cytotoxic
Externí odkaz:
https://doaj.org/article/117e48c4e3144f3a95391d6e05adedf1
Autor:
Lawrence Wrabetz, Nicholas Silvestri, Jordan J. S. VerPlank, Alfred L. Goldberg, Joseph Gawron, M. Laura Feltri
Publikováno v:
Brain
Agents that raise cyclic guanosine monophosphate (cGMP) by activating protein kinase G increase 26S proteasome activities, protein ubiquitination and degradation of misfolded proteins. Therefore, they may be useful in treating neurodegenerative and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6216593573507658a8be0fca0a74f11
https://doi.org/10.1093/brain/awab249
https://doi.org/10.1093/brain/awab249