Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Joseph G. Vos"'
Autor:
Joseph G. Vos, Aldert H. Piersma, Leo T.M. van der Ven, Alfons Hack, Hellmuth Lilienthal, Astrid Roth-Härer
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 15:76-86
The widespread use of brominated flame retardants (BFRs) has led to increasing concentrations in environmental samples. Previous reports suggested endocrine activity of these compounds. Because thyroid hormones and sex steroids are known to regulate
Autor:
Harry van Steeg, Coen F. van Kreijl, Annemieke de Vries, Jolanda van den Berg, Rudolf B. Beems, Joseph G. Vos, Jan van Benthem, Conny T. M. van Oostrom, Esther M. Hoogervorst
Publikováno v:
DNA Repair. 4:3-9
The nucleotide excision repair (NER) pathway comprises two sub-pathways, transcription coupled repair (TCR) and global genome repair (GGR). To establish the importance of these separate sub-pathways in tumor suppression, we exposed mice deficient for
Publikováno v:
Toxicology. 205:27-32
Toxicologic pathology is a classical discipline in the toxicology arena, and despite various emerging techniques, still is a major cornerstone in the process of hazard identification and risk characterization. Most knowledge derives from laboratory a
Autor:
Jolanda P. Vermeulen, Harry van Steeg, Piet W. Wester, Rudolf B. Beems, Jan van Benthem, Joseph G. Vos, Siska Gielis, Annemieke de Vries, Conny Th. M. van Oostrom, Esther M. Hoogervorst
Publikováno v:
Cancer Research. 64:5118-5126
Both nucleotide excision repair (NER) and the p53 tumor suppressor protein play crucial roles in the prevention of cells becoming cancerous. This is clearly demonstrated by the fact that NER-deficient xeroderma pigmentosum patients and Li-Fraumeni pa
Publikováno v:
Toxicological Sciences. 78:88-95
Hexachlorobenzene (HCB) is a persistent environmental pollut- ant with (auto)immune effects in humans and rats. The Brown Norway (BN) rat is very susceptible to HCB-induced immunopa- thology, and oral exposure causes inflammatory skin and lung lesion
Publikováno v:
Journal of Immunotoxicology, 1, 1-12. Informa Healthcare
Exposure to ultraviolet (UV) radiation, as in sunlight, can modulate immune responses in animals and humans. This immunomodulation can lead to positive health effects especially with respect to certain autoimmune diseases and allergies. However, UV-i
Autor:
C. Frieke Kuper, Joseph G. Vos
Publikováno v:
Journal of Toxicologic Pathology. 17:137-146
Toxicological pathology of lymphoid organs plays an important role in the risk assessment process of immunotoxicants. Identification of chemicals that have the potential to cause injury to the immune system is of considerable public health significan
Autor:
Janine Ezendam, Frank Staedtler, Jeroen Pennings, Rob J Vandebriel, Raymond Pieters, Paolo Boffetta, Johannes H Harleman, Joseph G Vos
Publikováno v:
Environmental Health Perspectives
Hexachlorobenzene (HCB) is a persistent environmental pollutant with toxic effects in man and rat. Reported adverse effects are hepatic porphyria, neurotoxicity, and adverse effects on the reproductive and immune system. To obtain more insight into H
Autor:
Annemieke de Vries, Harry van Steeg, Marianne Roodbergen, Jan Vijg, Piet W. Wester, Conny T. M. van Oostrom, Esther M. Hoogervorst, Joseph G. Vos, Wendy Bruins, Flemming R. Cassee, Rudolf B. Beems, Frederik J. van Schooten
Publikováno v:
Carcinogenesis, 24(3), 613-619. Oxford University Press
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice.Hoogervorst EM, de Vries A, Beems RB, van Oostrom CT, Wester PW, Vos JG, Bruins W, Roodbergen M, Cassee FR, Vijg J, v
Publikováno v:
Clinical and Vaccine Immunology. 10:59-65
We have investigated the effect of orally administered Lactobacillus casei Shirota ( L. casei ) on immunological memory, as measured by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR). The studies were performed in animal m