Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joseph G. Taylor"'
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
Classical Hodgkin lymphoma (CHL) is unusually sensitive to PD1 inhibition and PDL1 is highly expressed on CHL cells and in the tumor microenvironment. This could be interpreted as evidence of exhaustion, but paradoxically, PD1+ lymphocyte infiltratio
Externí odkaz:
https://doaj.org/article/053d5a6c2df048349881810681491b5d
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
Externí odkaz:
https://doaj.org/article/63d82e5de6444bc39a2629f4646a0cbe
Autor:
Louise E. Reynolds, John G. Gribben, Joseph G Taylor, Andrew Clear, Kairbaan Hodivala-Dilke, Tarek M. A. Abdel-Fatah, Louise Jones, Stephen Chan, Marina Roy-Luzarraga
Publikováno v:
JAMA Network Open
Key Points Question Are phosphorylated–focal adhesion kinase (pY397-FAK) expression levels in endothelial or tumor cells and tumor blood vessel density associated with response to chemotherapy and relapse-free survival after neoadjuvant chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8202f3636d2d3d2c1ebae0c463938985
http://europepmc.org/articles/PMC7592032
http://europepmc.org/articles/PMC7592032
Publikováno v:
Blood. 136:33-34
Background: Treatment failure after RCHOP is associated with poor outcome in DLBCL. Despite considerable immune system variation among individual patients, the diagnostic absolute monocyte (AMC) and absolute lymphocyte (ALC) counts can reproducibly s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830a94fd75ef499bea377e5909af64a4
https://doi.org/10.1182/blood-2020-143104
https://doi.org/10.1182/blood-2020-143104
Publikováno v:
Haematologica. 104:e42-e44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a57695808cc63c72b8eceadfdecf7ba
https://doi.org/10.3324/haematol.2018.204818
https://doi.org/10.3324/haematol.2018.204818
Autor:
Joseph G Taylor, John G. Gribben
Publikováno v:
Seminars in Cancer Biology. 34:36-45
Innate and adaptive immune cells within the microenvironment identify and eliminate cells displaying signs of malignant potential. Immunosurveillance effector Natural Killer (NK) cells and Cytotoxic T Lymphocyte (CTLs) identify malignant cells throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5375ba7db2ad39ac120a63df2b3f2be8
https://doi.org/10.1016/j.semcancer.2015.07.004
https://doi.org/10.1016/j.semcancer.2015.07.004
Publikováno v:
Biomarkers in Medicine. 9:473-482
There has been considerable interest in the role of the lymphoma microenvironment. Despite the use of highly active antiretroviral therapy (HAART), AIDS-related diffuse large-B-cell lymphoma remains common and HIV-associated classical Hodgkin's lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b82c4aecd26943dfd75e90e59f637
https://doi.org/10.2217/bmm.15.13
https://doi.org/10.2217/bmm.15.13
Publikováno v:
Blood. 134:658-658
Background: PD1 inhibitor (PD1i) efficacy is taken as evidence of T cell exhaustion in Classical Hodgkin Lymphoma (CHL), however, direct evidence for exhaustion is limited. PD1 expression does not predict PD1i response in CHL. Additionally, PDL1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6329b2ec78ec31ba6fd292b33cdcc87
https://doi.org/10.1182/blood-2019-125247
https://doi.org/10.1182/blood-2019-125247
Autor:
John G. Gribben, Frances Seymour, Mariarita Calaminici, Andrew Clear, Edward Truelove, Joseph G Taylor
Publikováno v:
Blood. 134:5240-5240
Diffuse large B-cell Lymphoma (DLBCL) is the most frequent non-Hodgkin's lymphoma with 3 molecularly distinct subtypes based on cell of origin. Genetic alterations in DLBCL, expression of checkpoint molecules and an immunosuppressive microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3666f7ce9b3c061c2b1c4f5f5a609405
https://doi.org/10.1182/blood-2019-130712
https://doi.org/10.1182/blood-2019-130712
Publikováno v:
Blood. 132:4124-4124
Introduction: Classical Hodgkin Lymphoma (CHL) is responsive to Programmed Death 1 inhibition (PD1i). Recognition that 9p24 amplifications promote PDL1 upregulation in lymphoma cells provides insight into CHL's particular sensitivity to PD1 inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::485afebecd50e977369582c04b42cea9
https://doi.org/10.1182/blood-2018-99-119126
https://doi.org/10.1182/blood-2018-99-119126