Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joseph G. Laird"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The voltage-gated calcium channel, Cav1.4 is localized to photoreceptor ribbon synapses and functions both in molecular organization of the synapse and in regulating release of synaptic vesicles. Mutations in Cav1.4 subunits typically present as eith
Externí odkaz:
https://doaj.org/article/9732e646ac224baab601a6e84ffe7af6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Vision, hearing, smell, taste, and touch are the tools used to perceive and navigate the world. They enable us to obtain essential resources such as food and highly desired resources such as mates. Thanks to the investments in biomedical research the
Externí odkaz:
https://doaj.org/article/b2f5313304f548ba8b7f0835df6f765b
Autor:
Shivangi M. Inamdar, Deepak Poria, Colten K Lankford, Joseph G. Laird, Vladimir J. Kefalov, Sheila A. Baker, Eduardo Solessio
Publikováno v:
Hum Mol Genet
The voltage-gated potassium channel responsible for controlling photoreceptor signaling is a heteromeric complex of Kv2.1 subunits with a regulatory Kv8.2 subunit. Kv2.1/Kv8.2 channels are localized to the photoreceptor inner segment and carry IKx, l
Autor:
Sarah H. Gardner, Arlene V. Drack, Sajag Bhattarai, Nikolai O. Artemyev, Vasily Kerov, Rachel O.L. Wong, Wade R. Gutierrez, Sharmon Knecht, Daniel Soh, Jussara Hagen, Amy S. Lee, Mei Ling Joiner, Teresa Puthussery, Sheila A. Baker, Takeshi Yoshimatsu, Joseph G. Laird
Publikováno v:
The Journal of Neuroscience. 38:6145-6160
α2δ-4 is an auxiliary subunit of voltage-gated Cav1.4 L-type channels that regulate the development and mature exocytotic function of the photoreceptor ribbon synapse. In humans, mutations in the CACNA2D4 gene encoding α2δ-4 cause heterogeneous f
Publikováno v:
Biological Journal of the Linnean Society. 118:472-485
An organism's morphology is constrained by its evolutionary history and the need to meet a variety of potentially competing functions. The ant genus Pheidole is the most species-rich ant genus and almost every species has a dimorphic worker caste (a
Autor:
Yuan Pan, Modestos A Modestou, Joseph G. Laird, Maxim Sokolov, David M. Yamaguchi, Sheila A. Baker, Hongman Song
Publikováno v:
Traffic. 16:1239-1253
Na(+) /K(+) -ATPase (NKA) participates in setting electrochemical gradients, cardiotonic steroid signaling and cellular adhesion. Distinct isoforms of NKA are found in different tissues and subcellular localization patterns. For example, NKA α1 is w
Autor:
S. Scott Whitmore, Todd E. Scheetz, Shivangi M. Inamdar, Nicole Tatro, Colten K Lankford, Joseph G. Laird, Gulnara Novbatova, Sheila A. Baker
Publikováno v:
Experimental eye research. 170
The 14-3-3 family of proteins has undergone considerable expansion in higher eukaryotes with humans and mice expressing seven isoforms (β, e, η, γ, θ, ζ, and σ) from seven distinct genes (YWHAB, YWAHE, YWHAH, YWHAG, YWHAQ, YWHAZ, and SFN). Grow
Publikováno v:
Cellular and Molecular Life Sciences
Hyperpolarization-activated cyclic nucleotide-gated 1 (HCN1) channels carry Ih, which contributes to neuronal excitability and signal transmission in the nervous system. Controlling the trafficking of HCN1 is an important aspect of its regulation, ye
Autor:
Vasily, Kerov, Joseph G, Laird, Mei-Ling, Joiner, Sharmon, Knecht, Daniel, Soh, Jussara, Hagen, Sarah H, Gardner, Wade, Gutierrez, Takeshi, Yoshimatsu, Sajag, Bhattarai, Teresa, Puthussery, Nikolai O, Artemyev, Arlene V, Drack, Rachel O, Wong, Sheila A, Baker, Amy, Lee
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(27)
α2δ-4 is an auxiliary subunit of voltage-gated Cav1.4 L-type channels that regulate the development and mature exocytotic function of the photoreceptor ribbon synapse. In humans, mutations in the CACNA2D4 gene encoding α2δ-4 cause heterogeneous f
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Cav1.4 is a voltage-gated calcium channel clustered at the presynaptic active zones of photoreceptors. Cav1.4 functions in communication by mediating the Ca2+ influx that triggers neurotransmitter release. It also aids in development since ro