Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Joseph G Wettstein"'
Autor:
Stephen R Morairty, Florent G Revel, Pari Malherbe, Jean-Luc Moreau, Daniel Valladao, Joseph G Wettstein, Thomas S Kilduff, Edilio Borroni
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39131 (2012)
The hypocretin (orexin) system is involved in sleep/wake regulation, and antagonists of both hypocretin receptor type 1 (HCRTR1) and/or HCRTR2 are considered to be potential hypnotic medications. It is currently unclear whether blockade of either or
Externí odkaz:
https://doaj.org/article/869b204300724eeea846840bc51ce84a
Autor:
Georg Jaeschke, Urs Niederhauser, Beatrice David, Eric Vieira, Will Spooren, Martin Kuratli, Jens-Uwe Peters, Michael Honer, Wolfgang Guba, Thomas Hartung, Daniel Tännler, Christoph Funk, Nadia Bitter-Stoll, Porter Richard Hugh Phillip, Bernd Büttelmann, Daniel Rueher, Paul Spurr, Jörg Huwyler, Nicole Clemann, Eric Prinssen, Joseph G. Wettstein, Axel Pähler, Simona M. Ceccarelli, Patrick Boissin, Theodor Stoll, Antonio Ricci, Jürgen Wichmann, Ann Petersen, Manfred Schneider, Marianne Rueher, Edilio Borroni, Sabine Kolczewski, Anthony Harrison, Lothar Lindemann
Publikováno v:
Journal of Medicinal Chemistry. 58:1358-1371
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential for the treatment of psychiatric diseases including depression, fragile X syndrome (FXS), anxiety, obsessive-compulsive disorders, and levodopa induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f629d43eba9d48337f793d5244811596
https://doi.org/10.1021/jm501642c
https://doi.org/10.1021/jm501642c
Autor:
Marianne B. Müller, Georg Jaschke, Christoph W. Turck, Alexander S. Häusl, Mathias V. Schmidt, D. Harbich, Gengjing Zhao, Theo Rein, Sara Santarelli, Marcel Schieven, Christiana Labermaier, Joseph G. Wettstein, Nils C. Gassen, Klaus V. Wagner, Xiao-Dong Wang, Bianca Schmid, Jakob Hartmann, Natalie Matosin, Christine Kohl, Lothar Lindemann, Christian Webhofer
Publikováno v:
Europe PubMed Central
Stress-induced psychiatric disorders, such as depression, have recently been linked to changes in glutamate transmission in the central nervous system. Glutamate signaling is mediated by a range of receptors, including metabotropic glutamate receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb16eac855e7eff73a6fd505315d6038
https://doi.org/10.1038/npp.2014.308
https://doi.org/10.1038/npp.2014.308
This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in chi
Autor:
Eric Prinssen, Christophe Grundschober, Laurent B. Nicolas, Jean-Luc Moreau, Joseph G. Wettstein, Cristina Lopez-Lopez, Andreas Bruns, Steffen Klein, Melanie S. Keßler, Markus von Kienlin, Celine Risterucci
Publikováno v:
European Neuropsychopharmacology. 22:441-451
Functional magnetic resonance imaging (fMRI) has become an important method in clinical psychiatry research whereas there are still only few comparable preclinical investigations. Herein, we report that fMRI in rats can provide key information regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de0cac1d79ca6643817cb0d3de0d503
https://doi.org/10.1016/j.euroneuro.2011.11.001
https://doi.org/10.1016/j.euroneuro.2011.11.001
Autor:
Aubin Michalon, Mark F. Bear, Theresa M. Ballard, Lothar Lindemann, Will Spooren, Michael S. Sidorov, Joseph G. Wettstein, Georg Jaeschke, Laurence Ozmen
Publikováno v:
Neuron. 74:49-56
SummaryFragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, but a crucial unanswered question is whether pharmacological mGlu5 inhibition is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e418e7a0eb48e39df24d35908b8e371a
https://doi.org/10.1016/j.neuron.2012.03.009
https://doi.org/10.1016/j.neuron.2012.03.009
Autor:
Joseph G. Wettstein, Bríd Á. Nic Dhonnchadha, Daniela Alberati, Roger D. Spealman, Emmanuel Pinard, Kathleen M. Kantak
Publikováno v:
Drug and Alcohol Dependence. 122:119-126
Combining extinction training with cognitive-enhancing pharmacotherapy represents a novel strategy for improving the efficacy of exposure therapy for drug relapse prevention. We investigated if the selective glycine transporter-1 (GlyT-1) inhibitor R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2542053170302c08751d7748e6301fa
https://doi.org/10.1016/j.drugalcdep.2011.09.017
https://doi.org/10.1016/j.drugalcdep.2011.09.017
Autor:
Gerhard Hoffmann, Will Spooren, Eric Prinssen, Silvia Gatti, Thomas Hartung, Michael Honer, Neil Parrott, Bernd Büttelmann, Lothar Lindemann, Porter Richard Hugh Phillip, Georg Jaeschke, Christophe Fischer, Sabine Kolczewski, Eric Vieira, Aubin Michalon, Christophe Flament, Joseph G. Wettstein, Catherine Diener
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 339:474-486
The metabotropic glutamate receptor 5 (mGlu5) is a glutamate-activated class C G protein-coupled receptor widely expressed in the central nervous system and clinically investigated as a drug target for a range of indications, including depression, Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bd76b52481ac1f6b61f6cb201859d2
https://doi.org/10.1124/jpet.111.185660
https://doi.org/10.1124/jpet.111.185660
Publikováno v:
Pharmacology, Biochemistry and Behavior, 99(2), 130-145. Elsevier Inc.
The investigation of novel drug targets for treating cognitive impairments associated with neurological and psychiatric disorders remains a primary focus of study in central nervous system (CNS) research. Many promising new therapies are progressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e57ba3d580565ba0933bad03de8bf18
https://doi.org/10.1016/j.pbb.2011.03.022
https://doi.org/10.1016/j.pbb.2011.03.022
Autor:
Katrin Groebke Zbinden, Claas A. Meyer, Jean-Luc Moreau, Tatyana D. Sotnikova, Sean Durkin, Bernhard Bettler, Florent G. Revel, Sylvie Chaboz, Bruno Pouzet, Roger David Norcross, Amyaouch Bradaia, Raul R. Gainetdinov, Marc G. Caron, Marius C. Hoener, Veit Metzler, Laurence Ozmen, Gerhard Trube, Joseph G. Wettstein, Roland Mory
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711fb0936ee0adbdc01f4d6a3d2bb28e
https://doi.org/10.1073/pnas.1103029108
https://doi.org/10.1073/pnas.1103029108