Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph G Sodroski"'
Autor:
Vinita R Joshi, Ruchi M Newman, Melissa L Pack, Karen A Power, James B Munro, Ken Okawa, Navid Madani, Joseph G Sodroski, Aaron G Schmidt, Todd M Allen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008577 (2020)
The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the g
Externí odkaz:
https://doaj.org/article/e3859f10b003443bab3cc267b1c5c2ec
Autor:
Zhiqing Zhang, Saumya Anang, Hanh T. Nguyen, Christopher Fritschi, Amos B. Smith, III, Joseph G. Sodroski
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110141- (2024)
Summary: The pretriggered conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ((gp120/gp41)3) is targeted by virus entry inhibitors and broadly neutralizing antibodies (bNAbs). The lability of pretriggered Env
Externí odkaz:
https://doaj.org/article/13ad27a9b3324a2ab13ce79cb7ad7d65
Autor:
S Gnanakaran, Tanmoy Bhattacharya, Marcus Daniels, Brandon F Keele, Peter T Hraber, Alan S Lapedes, Tongye Shen, Brian Gaschen, Mohan Krishnamoorthy, Hui Li, Julie M Decker, Jesus F Salazar-Gonzalez, Shuyi Wang, Chunlai Jiang, Feng Gao, Ronald Swanstrom, Jeffrey A Anderson, Li-Hua Ping, Myron S Cohen, Martin Markowitz, Paul A Goepfert, Michael S Saag, Joseph J Eron, Charles B Hicks, William A Blattner, Georgia D Tomaras, Mohammed Asmal, Norman L Letvin, Peter B Gilbert, Allan C Decamp, Craig A Magaret, William R Schief, Yih-En Andrew Ban, Ming Zhang, Kelly A Soderberg, Joseph G Sodroski, Barton F Haynes, George M Shaw, Beatrice H Hahn, Bette Korber
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002209 (2011)
Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in infection that may be favored at transmission, as well as patterns of recurrent mutation in chronic infection that may reflect common pathways of immune evasion.
Externí odkaz:
https://doaj.org/article/22d53c62f6de46ae98a1717e386d0e84
Autor:
Alon Herschhorn, Andres Finzi, David M Jones, Joel R Courter, Akihiro Sugawara, Amos B Smith, Joseph G Sodroski
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26731 (2011)
HIV-1 envelope glycoproteins (Envs) mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. Entry inhibitors with broad-range activity against diverse isolates of HI
Externí odkaz:
https://doaj.org/article/9adaabb1a1a84f2787ae00f0a349aecb
Autor:
Cheyenne Chaplain, Christopher J. Fritschi, Saumya Anang, Zhen Gong, Jonathan Richard, Catherine Bourassa, Shuaiyi Liang, Mohammadjavad Mohammadi, Jun Park, Andrés Finzi, Navid Madani, Joseph G. Sodroski, Cameron F. Abrams, Wayne A. Hendrickson, Amos B. Smith
Publikováno v:
ACS Medicinal Chemistry Letters. 14:51-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742d43d98be0abecae8693d70dc27ddb
https://doi.org/10.1021/acsmedchemlett.2c00376
https://doi.org/10.1021/acsmedchemlett.2c00376
Autor:
Rong Zhou, Shijian Zhang, Hanh T. Nguyen, Haitao Ding, Althea Gaffney, John C. Kappes, Amos B. Smith, Joseph G. Sodroski
Publikováno v:
Journal of Virology.
The human immunodeficiency virus (HIV) envelope glycoproteins (Envs) in the viral membrane mediate virus entry into the host cell and are targeted by neutralizing antibodies elicited by natural infection or vaccines. Detailed studies of membrane prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5faaaa3718e7a7b3b30b3271f2ad5723
https://doi.org/10.1128/jvi.00327-23
https://doi.org/10.1128/jvi.00327-23
Publikováno v:
Journal of Virology. 97
Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the viral envelope glycoprotein (Env) trimer ((gp120/gp41)3) by the primary receptor, CD4, and coreceptors, CCR5 or CXCR4. The pretriggered (State-1) conformation of the mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd1fcf9bd8ceee43f9366a3ce98915b
https://doi.org/10.1128/jvi.01857-22
https://doi.org/10.1128/jvi.01857-22
Autor:
Rong Zhou, Shijian Zhang, Hanh T. Nguyen, Haitao Ding, Althea Gaffney, John C. Kappes, Amos B. Smith, Joseph G. Sodroski
The mature human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer, which consists of non-covalently associated gp120 exterior and gp41 transmembrane subunits, mediates virus entry into cells. The pretriggered (State-1) Env conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fea3c743e72b9c7af0fc0c909afc6f3
https://doi.org/10.1101/2023.03.01.530731
https://doi.org/10.1101/2023.03.01.530731
Autor:
Hanh T. Nguyen, Alessandra Qualizza, Saumya Anang, Meiqing Zhao, Shitao Zou, Rong Zhou, Qian Wang, Shijian Zhang, Ashlesha Deshpande, Haitao Ding, Ta-Jung Chiu, Amos B. Smith, John C. Kappes, Joseph G. Sodroski
Publikováno v:
J Virol
Binding to the receptor, CD4, drives the pretriggered, “closed” (state-1) conformation of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more “open” conformations (states 2 and 3). Broadly neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627104fb4f223f1911581097fbdec219
https://doi.org/10.1128/jvi.01668-21
https://doi.org/10.1128/jvi.01668-21
Autor:
Qian Wang, Saumya Anang, Sho Iketani, Yicheng Guo, Lihong Liu, David D. Ho, Joseph G. Sodroski
SUMMARYThe recently emerged B.1.1.529 (Omicron) SARS-CoV-2 variant has a highly divergent spike (S) glycoprotein. We compared the functional properties of B.1.1.529 S with those of previous globally prevalent SARS-CoV-2 variants, D614G and B.1.617.2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f0e01b9e6e2d3390883522d3982cd4f
https://doi.org/10.1101/2021.12.27.474288
https://doi.org/10.1101/2021.12.27.474288