Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Joseph G Culotti"'
Autor:
Joseph Veyhl, Robert J Dunn, Wendy L Johnston, Alexa Bennett, Lijia W Zhang, James W Dennis, Harry Schachter, Joseph G Culotti
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their func
Externí odkaz:
https://doaj.org/article/0a3cd235050f44908f27406dc15e0633
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005446 (2015)
Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5. These two
Externí odkaz:
https://doaj.org/article/6296950d00ba4d84af4f2e761145cddf
Autor:
Naomi Levy-Strumpf, Joseph G Culotti
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004381 (2014)
Guided migrations of cells and developing axons along the dorso-ventral (D/V) and antero-posterior (A/P) body axes govern tissue patterning and neuronal connections. In C. elegans, as in vertebrates, D/V and A/P graded distributions of UNC-6/Netrin a
Externí odkaz:
https://doaj.org/article/d859e15027ad486d9ea8dae1e387a4f1
Autor:
Suneil K. Kalia, Omar M. A. El-Agnaf, Jarlath Byrne Rodgers, Aldis Krizus, Minesh Kapadia, Darren M O'Hara, Kazuko Fujisawa, Lorraine V. Kalia, Krystal Menezes, Joseph G. Culotti, Kevin S Chen, William S. Ryu, Susan Ping, Naomi P. Visanji, Hien Chau, Grishma Pawar, Satoshi Suo, Nour K. Majbour, Seiya Ishikura, Andres M. Lozano, Scott Spangler, Nhat Tran, Anna Cranston, Alix M. B. Lacoste, Shahin Khodaei, Connie Marras
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-25 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-25 (2021)
Background Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s disease, but dr
Publikováno v:
Development (Cambridge, England). 147(14)
Long-term survival of an animal species depends on development being robust to environmental variations and climate changes. We used C. elegans to study how mechanisms that sense environmental changes trigger adaptive responses that ensure animals de
Autor:
James W. Dennis, Lijia W. Zhang, Joseph G. Culotti, Wendy L. Johnston, Alexa Bennett, Joseph Veyhl, Harry Schachter, Robert J. Dunn
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
PLoS ONE, Vol 12, Iss 8, p e0183049 (2017)
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their func
Publikováno v:
Development. 140:4020-4030
Graded distributions of netrin and semaphorin guidance cues convey instructive polarity information to migrating cells and growth cones, but also have permissive (i.e. non-polarity determining) functions in mammalian development and repair. The permi
Publikováno v:
Genetics. 192:959-971
Netrin and semaphorin axon guidance cues have been found to function in the genesis of several mammalian organs; however, little is known about the underlying molecular mechanisms involved. A genetic approach could help to reveal the underpinnings of
Autor:
Hong Zheng, Richard Ikegami, Gian Garriga, Louise Brown, Kristin Simokat, Jeff Hardin, Joseph G. Culotti
Publikováno v:
Current Biology. 22(1):1-11
Summary Background In the last stage of the Caenorhabditis elegans body wall closure, an open pocket in the epidermis is closed by the migration of marginal epidermal P/pocket cells to the ventral midline. The cellular and molecular mechanisms of thi
Autor:
Lesley T. MacNeil, Jeffrey A. Lieberman, James L. Kennedy, Marco Aurélio Romano-Silva, Albert H.C. Wong, Herbert Y. Meltzer, Renan P. Souza, Joseph G. Culotti
Publikováno v:
Journal of Psychiatric Research. 44:700-706
GDNF (glial-cell-line derived neurotrophic factor) is a potent neurotrophic factor for dopaminergic neurons. Neuropsychiatric diseases and their treatments are associated with alterations in the levels of both GDNF and its receptor family (GDNF famil