Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joseph Géczy"'
Publikováno v:
Advances in Therapy. 23:601-614
Prolonged-release molsidomine 16 mg once daily) QD (has proved effective in the short-term treatment of patients with stable angina. The purpose of this multicenter study was to assess its long-term tolerability and clinical effectiveness. A total of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323acb41a035b184b99dc8b26ba37df8
https://doi.org/10.1007/bf02850048
https://doi.org/10.1007/bf02850048
Publikováno v:
Advances in Therapy. 23:107-130
Molsidomine, a sydnonimine acting as a heterocyclic direct nitric oxide donor, has been used for many years in several European countries for the treatment of patients with stable angina pectoris. The efficacy and tolerability of a novel once-daily 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc66f93fdbefd7c9adb2364214e4cd0b
https://doi.org/10.1007/bf02850352
https://doi.org/10.1007/bf02850352
Autor:
Claude Dubois, Roger Messin, Joseph Géczy, Jean Pierre Famaey, Grzegorz Opolski, Fabienne Carreer-Bruhwyler, T. Fenyvesi
Publikováno v:
International Journal of Cardiology. 98:79-89
Background: The objective of this study was to compare the efficacy and tolerability of molsidomine prolonged-release 16 mg once-a-day (o.a.d.) with 8 mg twice-a-day (b.i.d.) and placebo in patients with stable angina pectoris. Methods: After a run-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149133173cfdc670feb7099194cfe047
https://doi.org/10.1016/j.ijcard.2004.01.007
https://doi.org/10.1016/j.ijcard.2004.01.007
Publikováno v:
Heart Drug. 4:184-189
Background: A once-daily 16-mg-dose formulation of molsidomine (Coruno® tablets) was recently developed for the chronic treatment of angina pectoris. It required efficacy and safety testing. Objective: The objective of the present study was to compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d29e8e6df734d4f97e02329d35e52f
https://doi.org/10.1159/000082189
https://doi.org/10.1159/000082189
Autor:
Jacques Crommen, Fabienne Carreer-Bruhwyler, Claude Dubois, Patrice Chiap, Roger Messin, André Herchuelz, Philippe Hubert, Joseph Géczy, Jean Pierre Famaey
Publikováno v:
American Journal of Drug Delivery. 2:131-141
Molsidomine is a direct nitric oxide donor routinely used in the oral treatment of stable angina pectoris. It was initially available as 4mg immediate-release tablets to be taken three to four times a day. New galenic formulations have been developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7648a7f8cbe9210036c0df5b0bf93d4c
https://doi.org/10.2165/00137696-200402020-00005
https://doi.org/10.2165/00137696-200402020-00005
Autor:
Didier Laeckmann, Christelle Prosperi-Meys, Jacques Delarge, Bernard Masereel, Joseph Géczy, F. Rogister, Jean Victor Dejardin
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:1793-1804
Pyridine and benzene bioisosteres of amiloride were synthesized and evaluated for their inhibitory potency against the sodium-hydrogen exchanger (NHE) involved in intracellular pH regulation. The inhibition of NHE was determined by using the platelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfbdcb7ec3b68dd9705126168e5d177
https://doi.org/10.1016/s0968-0896(02)00022-6
https://doi.org/10.1016/s0968-0896(02)00022-6
Autor:
F. Rogister, Carine Maggetto, Jacques Delarge, Bernard Masereel, Marianne Ghyoot, Françoise Van Eylen, Jean-François Liégeois, André Herchuelz, Didier Laeckmann, P O Plasman, Joseph Géczy
Publikováno v:
European Journal of Medicinal Chemistry. 36:597-614
A series of N-guanidino substituted 2,4-diamino-5-carbonylguanidine molecules related to amiloride were synthesised and evaluated for their ability to inhibit the sodium-calcium exchanger in rat insulinoma cells (RINm5F) and human platelets. Specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6006efd87d13593674a907db4a98bcea
https://doi.org/10.1016/s0223-5234(01)01247-8
https://doi.org/10.1016/s0223-5234(01)01247-8
Publikováno v:
Psychopharmacology. 157:228-235
Rationale: Neuroleptic or antipsychotic drugs are the mainstay of treating acute and chronic psychosis. However, their efficacy is offset by a wide array of side effects, especially extrapyramidal syndromes (EPS). In an attempt to develop novel antip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b0edeaf92670fb5a7877cedef7a53f
https://doi.org/10.1007/s002130100808
https://doi.org/10.1007/s002130100808
Autor:
Jacques Delarge, Christine Petit, Ginette Deby-Dupont, Jacques Damas, Yi Liao, Jacques Bruhwyler, Håkan Wikström, Jean-Michel Kauffmann, Jean-François Liégeois, Ange Mouithys-Mickalad, Joseph Géczy
Publikováno v:
Journal of Medicinal Chemistry, 44(5), 769-776. AMER CHEMICAL SOC
The chemical modification of clozapine (1) has permitted the finding of new analogues, e.g., olanzapine (2), quetiapine (3), 5-(4-methylpiperazin-1-yl)-8-chloropyrido[2,3-b] [1,5]benzoxazepine fumarate (9), with a clinical or psychopharmacological pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadf6d85d3788b2c5c63cb26b0f90422
https://hdl.handle.net/11370/2f126132-4781-457e-97b3-a4022e01bf92
https://hdl.handle.net/11370/2f126132-4781-457e-97b3-a4022e01bf92
Autor:
Jacqueline Scuvée-Moreau, Jacques Bruhwyler, Vincent Seutin, Albert Dresse, Joseph Géczy, Jacques Damas, Jean-François Liégeois, Jacques Delarge
Publikováno v:
European Journal of Pharmacology. 386:211-216
Using in vitro electrophysiological procedures, we confirm the inhibitory effect of 10-(4-methylpiperazin-1-yl)pyrido[4,3-b][1, 4]benzothiazepine (JL 3), on dorsal raphe serotonergic (IC(50)=14 microM) and noradrenergic neurons (IC(50)=4.5 microM). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab31379db67713b067a856b6edfeaf3
https://doi.org/10.1016/s0014-2999(99)00777-3
https://doi.org/10.1016/s0014-2999(99)00777-3