Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph G, Moloughney"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49862 (2012)
There is substantial evidence indicating that disruption of Ca(2+) homeostasis and activation of cytosolic proteases play a key role in the pathogenesis and progression of Duchenne Muscular Dystrophy (DMD). However, the exact nature of the Ca(2+) der
Externí odkaz:
https://doaj.org/article/16c3d516b4db4962b8cade199f705844
Autor:
Sharon Liu, Peter K. Kim, Austin Chang, Chadni Patel, Danielle Albaciete, Xiaoyang Su, Swati Rajput, Estela Jacinto, Joseph G. Moloughney, Guy Werlen, Cedric Magaway, Nicole M. Vega-Cotto, Chang Chih Wu
Publikováno v:
Journal of Biological Chemistry. 293:16464-16478
The mechanistic target of rapamycin (mTOR) controls metabolic pathways in response to nutrients. Recently, we have shown that mTOR complex 2 (mTORC2) modulates the hexosamine biosynthetic pathway (HBP) by promoting the expression of the key enzyme of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee5525b5fc5c46767b1a149da8cf4a8
https://doi.org/10.1074/jbc.ra118.003991
https://doi.org/10.1074/jbc.ra118.003991
Autor:
Thomas P. Lynch, Matthew Adlam, Sisi Zhang, Chang Chih Wu, Joseph G. Moloughney, Nicole M. Vega-Cotto, Joshua D. Rabinowitz, Guy Werlen, Estela Jacinto, Po Chien Chou, Peter K. Kim
Publikováno v:
Molecular cell. 63(5)
Highly proliferating cells are particularly dependent on glucose and glutamine for bioenergetics and macromolecule biosynthesis. The signals that respond to nutrient fluctuations to maintain metabolic homeostasis remain poorly understood. Here, we fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672e8243689b258ada803492a6bec079
https://pubmed.ncbi.nlm.nih.gov/27588599
https://pubmed.ncbi.nlm.nih.gov/27588599
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9783319342092
Cells metabolize nutrients to generate energy and building materials for growth and proliferation. In highly proliferating cells, such as cancer cells, there is an increased demand for nutrients with concomitant rerouting of metabolic pathways in fav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbe22924e69cf05edd823474ad7b100
https://doi.org/10.1007/978-3-319-34211-5_2
https://doi.org/10.1007/978-3-319-34211-5_2
Autor:
Haiyan Zhang, Claude E Monken, Shengkan Jin, Joseph G. Moloughney, Hanlin Tao, Edmund C. Lattime, Janice D. Thomas
Publikováno v:
Autophagy
The interactions between viruses and cellular autophagy have been widely reported. On the one hand, autophagy is an important innate immune response against viral infection. On the other hand, some viruses exploit the autophagy pathway for their surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40b34c09039c39af8a95ec9a29b2eab
Autor:
Guy Werlen, Estela Jacinto, Po-Chien Chou, Michael N. Hall, Joseph G. Moloughney, Won Jun Oh, Markus A. Rüegg, Chang-Chih Wu
An efficient immune response relies on the presence of T cells expressing a functional TCR. Whereas the mechanisms generating TCR diversity for antigenic recognition are well defined, what controls its surface expression is less known. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef32d1ec386fc1c4980c456af5b4f89c
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::619a4fff39093d2aa48ac0707c941ccf
https://doi.org/10.1096/fasebj.27.1_supplement.803.8
https://doi.org/10.1096/fasebj.27.1_supplement.803.8
Autor:
Noah Weisleder, Joseph G. Moloughney
Maintenance of the integrity of the plasma membrane is essential for maintenance of cellular function and prevention of cell death. Since the plasma membrane is frequently exposed to a variety of mechanical and chemical insults the cell has evolved a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebe005f6e4a258f561eaec07c2f78ea
https://europepmc.org/articles/PMC3756676/
https://europepmc.org/articles/PMC3756676/
Autor:
Peter K. Kim, Matthew Adlam, Estela Jacinto, Nicole M. Vega-Cotto, Chang-Chih Wu, Joshua D. Rabinowitz, Joseph G. Moloughney, Po-Chien Chou, Thomas P. Lynch, Guy Werlen, Sisi Zhang, Sai M Guntaka
Publikováno v:
Cancer Research. 76:21-21
Highly proliferating cells are particularly dependent on glucose and glutamine for bioenergetics and to fuel biosynthesis of macromolecules. The signals that respond to the fluctuations of these nutrients and how they control metabolic pathways remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e29ed12e445265bb7d0c0fb1ffd537
https://doi.org/10.1158/1538-7445.am2016-21
https://doi.org/10.1158/1538-7445.am2016-21
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966e953b65df932c3db5738017076e9c
https://doi.org/10.1096/fasebj.26.1_supplement.1001.3
https://doi.org/10.1096/fasebj.26.1_supplement.1001.3