Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Joseph F. Poduslo"'
Autor:
Liang Zhang, Sergey Trushin, Trace A. Christensen, Utkarsh Tripathi, Courtney Hong, Rachel E. Geroux, Kyle G. Howell, Joseph F. Poduslo, Eugenia Trushina
Publikováno v:
Neurobiology of Disease, Vol 114, Iss , Pp 1-16 (2018)
Inhibition of mitochondrial axonal trafficking by amyloid beta (Aβ) peptides has been implicated in early pathophysiology of Alzheimer's Disease (AD). Yet, it remains unclear whether the loss of motility inevitably induces the loss of mitochondrial
Externí odkaz:
https://doaj.org/article/52f1554e86a742b5b3c0ff9f6e53d363
Autor:
Joseph F. Poduslo, Thomas M. Wengenack, Geoffry L. Curran, Thomas Wisniewski, Einar M. Sigurdsson, Slobodon I. Macura, Bret J. Borowski, Clifford R. Jack, Jr.
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 315-329 (2002)
Smart molecular probes for both diagnostic and therapeutic purposes are expected to provide significant advances in clinical medicine and biomedical research. We describe such a probe that targets β-amyloid plaques of Alzheimer's disease and is dete
Externí odkaz:
https://doaj.org/article/956358b699344db491ef06e23ce8cc42
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 4, Pp 555-567 (2001)
The permeability of albumin, insulin, and human Aβ 1–40 at the blood–brain barrier (BBB) was determined in the normal adult mouse (B6/SJL) and in the double transgenic Alzheimer mouse (APP, PS1) by using an I.V. bolus injection technique to quan
Externí odkaz:
https://doaj.org/article/5fa2caa70a204de2a90de989dbe086bd
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 3, Pp 190-199 (1999)
Since amyloid β-protein (Aβ) is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease, information regarding its permeability at the blood–brain barrier (BBB) will help elucidate the contribution of circul
Externí odkaz:
https://doaj.org/article/10eb7cb65d314e6da43f87078ea16c3e
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 1, Pp 27-34 (1997)
The permeability of normal human, the human Dutch variant, and the rat Aβ 1-40 proteins at the blood–brain barrier (BBB) was determined in the normal adult rat by quantifying the permeability coefficient–surface area (PS) product for each protei
Externí odkaz:
https://doaj.org/article/fb1274ed19cf404dae54cd08492c7c9c
Autor:
Andrew L, Zhou, Nidhi, Sharda, Vidur V, Sarma, Kristen M, Ahlschwede, Geoffry L, Curran, Xiaojia, Tang, Joseph F, Poduslo, Krishna R, Kalari, Val J, Lowe, Karunya K, Kandimalla
Publikováno v:
Journal of Alzheimer's Disease. 85:1031-1044
Background: Age is the most common risk factor for Alzheimer’s disease (AD), a neurodegenerative disorder characterized by the hallmarks of toxic amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles. Moreover, sub-physiological brain insuli
Autor:
Andrew L Zhou, Geoffry L. Curran, Val J. Lowe, Joseph F. Poduslo, Suresh Kumar Swaminathan, Ling Li, Karunya K. Kandimalla
Publikováno v:
J Pharmacol Exp Ther
Recent studies suggest that apolipoprotein A-I (ApoA-I), the major protein constituent of high-density lipoprotein particles, plays a critical role in preserving cerebrovascular integrity and reducing Alzheimer’s risk. ApoA-I present in brain is th
Autor:
Karunya K. Kandimalla, Joseph F. Poduslo, Jens T. Rosenberg, Samuel C. Grant, Kristen M. Ahlschwede, Robert B. Jenkins, Geoffry L. Curran, Gobinda Sarkar, S. Ramakrishnan
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 16:258-266
Accumulation of amyloid beta (Aβ) peptides in the cerebral vasculature, referred to as cerebral amyloid angiopathy (CAA), is widely observed in Alzheimer's disease (AD) brain and was shown to accelerate cognitive decline. There is no effective metho
Autor:
Eugenia Trushina, Emirhan Nemutlu, Song Zhang, Trace Christensen, Jon Camp, Janny Mesa, Ammar Siddiqui, Yasushi Tamura, Hiromi Sesaki, Thomas M Wengenack, Petras P Dzeja, Joseph F Poduslo
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32737 (2012)
The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve monitoring and predicting of AD progression. Mitochondrial dysfunction has been suggested to u
Externí odkaz:
https://doaj.org/article/e9f4c61c946440419d7386cc8cc29d9e
Autor:
Trace A. Christensen, Utkarsh Tripathi, Eugenia Trushina, Kyle G. Howell, Joseph F. Poduslo, Liang Zhang, Courtney Hong, Rachel E. Geroux, Sergey Trushin
Publikováno v:
Neurobiology of Disease, Vol 114, Iss, Pp 1-16 (2018)
Inhibition of mitochondrial axonal trafficking by amyloid beta (Aβ) peptides has been implicated in early pathophysiology of Alzheimer's Disease (AD). Yet, it remains unclear whether the loss of motility inevitably induces the loss of mitochondrial