Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joseph F. Gardocki"'
Publikováno v:
Epilepsia. 41:3-9
In this overview, we discuss the discovery and development of topiramate (TPM) as an anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic properties. In particular, we highlight its anticonvulsant profile in tradit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee70fe360e2b22f57dd9beef9c1276c6
https://doi.org/10.1111/j.1528-1157.2000.tb02163.x
https://doi.org/10.1111/j.1528-1157.2000.tb02163.x
Autor:
David F. McComsey, Russell J. Jr. Taylor, Samuel O. Nortey, Winston Ho, Philip P. Grous, Bruce E. Maryanoff, Allen B. Reitz, Joseph F. Gardocki, Richard P. Shank, Barry Dubinsky
Publikováno v:
Journal of medicinal chemistry. 38(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48576dc5bf2aebc55e22d8d7620993d8
https://pubmed.ncbi.nlm.nih.gov/7837226
https://pubmed.ncbi.nlm.nih.gov/7837226
Autor:
Robert B. Raffa, James J. Schupsky, Samuel O. Nortey, Richard P. Shank, Susanna J. Dodgson, Coralie B. Davis, Joseph F. Gardocki, Jeffry L. Vaught, Bruce E. Maryanoff
Publikováno v:
Epilepsia. 35(2)
Topiramate [TPM, 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] (RWJ-17021-000, formerly McN-4853) is a structurally novel antiepileptic drug (AED). The preclinical anticonvulsant profile suggests that TPM acts primarily by block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1564fc95e938836eac73e8a97862563d
https://pubmed.ncbi.nlm.nih.gov/8156972
https://pubmed.ncbi.nlm.nih.gov/8156972
Autor:
Joseph F. Gardocki, Harold R. Almond, Jeffry L. Vaught, John R. Carson, Robert B. Raffa, Michael J. Costanzo, Richard J. Carmosin
Publikováno v:
Journal of medicinal chemistry. 35(15)
2-Substituted 1-azabicycloalkanes (3- and 5-aryloctahydroindolizines 2 and 11, 3-cyclohexyloctahydroindolizine 12, 4-aryloctahydroquinolizines 13, and 3-arylhexahydropyrrolizines 14) constitute a new class of non-opiate antinociceptive agents. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70285c86fe37c4335fb1d405f3cd48ab
https://pubmed.ncbi.nlm.nih.gov/1495016
https://pubmed.ncbi.nlm.nih.gov/1495016
Publikováno v:
Journal of Medicinal Chemistry. 24:79-88
The for diastereomers of N-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzo[a]quinolizin-2-yl)-N-phenylpropanamide (7c, 7d, 9c, and 9d), which are conformationally restricted analogues of fentanyl, were synthesized and separately tested for analgesic activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5b0ce83708ad78cc8ea788d641ea76
https://doi.org/10.1021/jm00133a017
https://doi.org/10.1021/jm00133a017
Autor:
Paulette E. Setler, Bruce E. Maryanoff, Mccomsey David F, Joseph F. Gardocki, Michael J. Costanzo, Richard P. Shank, Craig R. Schneider
Publikováno v:
Journal of Medicinal Chemistry. 27:943-946
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba962f979f2d99a502454d40148f5df4
https://doi.org/10.1021/jm00374a001
https://doi.org/10.1021/jm00374a001
Autor:
Richard P. Shank, David F. McComsey, Paulette E. Setler, Michael J. Costanzo, Craig R. Schneider, Samuel O. Nortey, Bruce E. Maryanoff, Joseph F. Gardocki
Publikováno v:
Journal of Medicinal Chemistry. 30:1433-1454
A series of pyrrolo[2,1-a]isoquinolines, and related compounds, were examined for antidepressant-like activity, by virtue of their antagonism of tetrabenazine-induced ptosis and sedation, and inhibition of biogenic amine uptake. Thus, we have identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879d914c6db4735caa058ba8a4c0dc8a
https://doi.org/10.1021/jm00391a028
https://doi.org/10.1021/jm00391a028
Publikováno v:
Toxicology and Applied Pharmacology. 9:536-554
Doses of amphetamine were selected from the polyphasic mortality response curves for interaction studies with drugs representative of various pharmacologic groups that could be expected to interact with amphetamine. The results of these studies sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9074821688ba6a93ba1ad11cedd1893a
https://doi.org/10.1016/0041-008x(66)90015-9
https://doi.org/10.1016/0041-008x(66)90015-9
Autor:
Joseph F. Gardocki, Lloyd W. Hazleton
Publikováno v:
Journal of the American Pharmaceutical Association (Scientific ed.). 40:491-494
A series of experiments designed to identify and estimate metabolic products excreted in the urine of dogs following intravenous administration of parathion is described and the results reported. The principal urinary excretion product is believed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b6e53951722a5dcda4cb102df18ed
https://doi.org/10.1002/jps.3030401004
https://doi.org/10.1002/jps.3030401004
Publikováno v:
Physiology & Behavior. 8:811-815
The method of integrative EEG analysis has been used to establish ratios between amplitudes in the left and right cerebral hemispheres during spontaneous sleep in man, in cats and in rabbits. The data indicate that coincident with each occurrence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192eb86de5e874ad5ceaa4857d2e03d4
https://doi.org/10.1016/0031-9384(72)90289-2
https://doi.org/10.1016/0031-9384(72)90289-2