Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Joseph F. Cheer"'
Autor:
Miguel Á. Luján, Dan P. Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E. Bass, Carlos Paladini, Joseph F. Cheer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Brain levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) shape motivated behavior and nucleus accumbens (NAc) dopamine release. However, it is not clear whether mobilization of 2-AG specifically from midbrain dopamine neurons is nec
Externí odkaz:
https://doaj.org/article/ed702d16757442d7aa301ff6c0503f02
Autor:
Miguel Á. Luján, Brandon L. Oliver, Reana Young-Morrison, Sheila A. Engi, Lan-Yuan Zhang, Jennifer M. Wenzel, Yulong Li, Natalie E. Zlebnik, Joseph F. Cheer
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112553- (2023)
Summary: Understanding mesolimbic dopamine adaptations underlying vulnerability to drug relapse is essential to inform prognostic tools for effective treatment strategies. However, technical limitations have hindered the direct measurement of sub-sec
Externí odkaz:
https://doaj.org/article/9b05fc772c3a466287aef7bae1fe2dd5
Publikováno v:
Addiction Neuroscience, Vol 3, Iss , Pp 100022- (2022)
Cannabinoid type 1 receptors (CB1Rs) orchestrate brain reward circuitry and are prevalent neurobiological targets for endocannabinoids and cannabis in the mammalian brain. Decades of histological and electrophysiological studies have established CB1R
Externí odkaz:
https://doaj.org/article/67e49e4f905e4a94970a1d11fa5adec4
Autor:
Dan P. Covey, Joseph F. Cheer
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 481-490.e3 (2019)
Summary: Dopamine (DA) transmission in the nucleus accumbens (NAc) facilitates cue-reward associations and appetitive action. Reward-related accumbal DA release dynamics are traditionally ascribed to ventral tegmental area (VTA) DA neurons. Activatio
Externí odkaz:
https://doaj.org/article/77e2266e47bc438b9c06a2813b947a33
Autor:
Kara K. Cover, Utsav Gyawali, Willa G. Kerkhoff, Mary H. Patton, Chaoqi Mu, Michael G. White, Ashley E. Marquardt, Bradley M. Roberts, Joseph F. Cheer, Brian N. Mathur
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1389-1398.e3 (2019)
Summary: Glutamatergic projections of the thalamic rostral intralaminar nuclei of the thalamus (rILN) innervate the dorsal striatum (DS) and are implicated in dopamine (DA)-dependent incubation of drug seeking. However, the mechanism by which rILN si
Externí odkaz:
https://doaj.org/article/f8e9c1104b894fdf835643dfec62bebe
Autor:
Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A. Mejias-Aponte, Jorge A. Gomez, Gabriel E. Mateo-Semidey, Gerard M.J. Beaudoin, Carlos A. Paladini, Joseph F. Cheer, Marisela Morales
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1128-1142.e7 (2019)
Summary: Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area (VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both asymmetric and symmetric synapses on VTA dopamine neurons, but most of t
Externí odkaz:
https://doaj.org/article/defa00d29ee64dc08e3795bccabda37c
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 1997-2008 (2015)
Cocaine is a highly addictive drug that acts upon the brain’s reward circuitry via the inhibition of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from midbrain dopamine (DA) neurons that modulate cocaine’s effects
Externí odkaz:
https://doaj.org/article/ac148901324643cca13e69d92fcfc4e6
Autor:
Roger Cachope, Yolanda Mateo, Brian N. Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M. Lovinger, Joseph F. Cheer
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 33-41 (2012)
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic a
Externí odkaz:
https://doaj.org/article/198238d49aa547f6bbcd69334b4acd23
Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity
Autor:
Jennifer M. Wenzel, Natalie E. Zlebnik, Mary H. Patton, John R. Smethells, Victoria M. Ayvazian, Hannah M. Dantrassy, Lan-Yuan Zhang, Brian N. Mathur, Joseph F. Cheer
Publikováno v:
Neuropsychopharmacology.
Autor:
David M. Lovinger, Yolanda Mateo, Kari A. Johnson, Sheila A. Engi, Mario Antonazzo, Joseph F. Cheer
Publikováno v:
Nature Reviews Neuroscience. 23:191-203