Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Joseph F. Arboleda-Velasquez"'
Autor:
Stephanie Langella, Kyra Bonta, Yinghua Chen, Yi Su, Daniel Vasquez, David Aguillon, Natalia Acosta-Baena, Ana Y. Baena, Gloria Garcia-Ospina, Margarita Giraldo-Chica, Victoria Tirado, Claudia Muñoz, Silvia Ríos-Romenets, Claudia Guzman-Martínez, Jeremy J. Pruzin, Valentina Ghisays, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik, Pierre N. Tariot, Eric M. Reiman, Francisco Lopera, Yakeel T. Quiroz
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-9 (2024)
Abstract Background Apolipoprotein E (APOE) genotypes have been suggested to influence cognitive impairment and clinical onset in presenilin-1 (PSEN1) E280A carriers for autosomal dominant Alzheimer’s disease (ADAD). Less is known about their impac
Externí odkaz:
https://doaj.org/article/3234fbf9ef1a4a4bae611ce4cce7ba51
Autor:
Paula Perez-Corredor, Timothy E. Vanderleest, Guido N. Vacano, Justin S. Sanchez, Nelson D. Villalba-Moreno, Claudia Marino, Susanne Krasemann, Miguel A. Mendivil-Perez, David Aguillón, Marlene Jiménez-Del-Río, Ana Baena, Diego Sepulveda-Falla, Francisco Lopera, Yakeel T. Quiroz, Joseph F. Arboleda-Velasquez, Randall C. Mazzarino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
A patient with the PSEN1 E280A mutation and homozygous for APOE3 Christchurch (APOE3Ch) displayed extreme resistance to Alzheimer’s disease (AD) cognitive decline and tauopathy, despite having a high amyloid burden. To further investigate the diffe
Externí odkaz:
https://doaj.org/article/5a75deb4bb57460d9fea9624ee74d0f7
Autor:
Stephanie Langella, N. Gil Barksdale, Daniel Vasquez, David Aguillon, Yinghua Chen, Yi Su, Natalia Acosta-Baena, Juliana Acosta-Uribe, Ana Y. Baena, Gloria Garcia-Ospina, Margarita Giraldo-Chica, Victoria Tirado, Claudia Muñoz, Silvia Ríos-Romenets, Claudia Guzman-Martínez, Gabriel Oliveira, Hyun-Sik Yang, Clara Vila-Castelar, Jeremy J. Pruzin, Valentina Ghisays, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik, Eric M. Reiman, Francisco Lopera, Yakeel T. Quiroz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Autosomal dominant Alzheimer’s disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational at
Externí odkaz:
https://doaj.org/article/9a1d6c4d47d84daea1bb1b579cc1275f
Autor:
Santiago Delgado-Tirado, MD, Lucia Gonzalez-Buendia, MD, Miranda An, BA, Dhanesh Amarnani, MS, Daniela Isaacs-Bernal, BSc, Hannah Whitmore, PhD, Said Arevalo-Alquichire, PhD, David Leyton-Cifuentes, BME, Jose M. Ruiz-Moreno, MD, PhD, Joseph F. Arboleda-Velasquez, MD, PhD, Leo A. Kim, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 3, Pp 100163- (2022)
Purpose: To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization. Design: Preclinical experimental study. Participants: In vitr
Externí odkaz:
https://doaj.org/article/1d0498c427cb4c969e1ab719fee26a5c
Autor:
Eric M. Reiman, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Matthew J. Huentelman, Thomas G. Beach, Richard J. Caselli, Yinghua Chen, Yi Su, Amanda J. Myers, John Hardy, Jean Paul Vonsattel, Steven G. Younkin, David A. Bennett, Philip L. De Jager, Eric B. Larson, Paul K. Crane, C. Dirk Keene, M. Ilyas Kamboh, Julia K. Kofler, Linda Duque, John R. Gilbert, Harry E. Gwirtsman, Joseph D. Buxbaum, Dennis W. Dickson, Matthew P. Frosch, Bernardino F. Ghetti, Kathryn L. Lunetta, Li-San Wang, Bradley T. Hyman, Walter A. Kukull, Tatiana Foroud, Jonathan L. Haines, Richard P. Mayeux, Margaret A. Pericak-Vance, Julie A. Schneider, John Q. Trojanowski, Lindsay A. Farrer, Gerard D. Schellenberg, Gary W. Beecham, Thomas J. Montine, Gyungah R. Jun, The Alzheimer’s Disease Genetics Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE
Externí odkaz:
https://doaj.org/article/8db8cb1befa541b785dc4ef289037901
Autor:
Yesica Zuluaga Castaño, David Andrés Montoya-Arenas, Lina Velilla, Carolina Ospina, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Francisco Lopera
Publikováno v:
International Journal of Psychological Research, Vol 11, Iss 2, Pp 46-55 (2018)
CADASIL is the most common hereditary cause of repeated ischemic strokes, and has also been identified as a model of pure vascular dementia. The objective of this study was to establish the cognitive performance of asymptomatic carriers with the muta
Externí odkaz:
https://doaj.org/article/6cb0551341ea4f75aeb9c2cc8152f80c
Autor:
Yesica Zuluaga Castaño, David Andrés Montoya-Arenas, Lina Velilla, Carolina Ospina, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Francisco Lopera
Publikováno v:
International Journal of Psychological Research, Vol 11, Iss 2 (2018)
La Arteriopatía Cerebral Autosómica Dominante con Infartos Subcorticales y Leucoencefalopatía (CADASIL), es producida por mutaciones en el gen NOTCH3, es la causa hereditaria más común de accidentes cerebrovasculares isquémicos repetidos. Objet
Externí odkaz:
https://doaj.org/article/c3e7d03e855f454a98351167920513b8
Publikováno v:
Cold Spring Harbor perspectives in medicine.
The Notch signaling pathway is a highly versatile and evolutionarily conserved mechanism with an important role in cell fate determination. Notch signaling plays a vital role in vascular development, regulating several fundamental processes such as a
Autor:
Francisco Lopera, Claudia Marino, Anita S. Chandrahas, Michael O’Hare, Nelson David Villalba-Moreno, David Aguillon, Ana Baena, Justin S. Sanchez, Clara Vila-Castelar, Liliana Ramirez Gomez, Natalia Chmielewska, Gabriel M. Oliveira, Jessica Lisa Littau, Kristin Hartmann, Kyungeun Park, Susanne Krasemann, Markus Glatzel, Dorothee Schoemaker, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Said Arevalo-Alquichire, Kahira L. Saez-Torres, Dhanesh Amarnani, Leo A. Kim, Randall C. Mazzarino, Harper Gordon, Yamile Bocanegra, Andres Villegas, Xiaowu Gai, Moiz Bootwalla, Jianling Ji, Lishuang Shen, Kenneth S. Kosik, Yi Su, Yinghua Chen, Aaron Schultz, Reisa A. Sperling, Keith Johnson, Eric M. Reiman, Diego Sepulveda-Falla, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz
Publikováno v:
Nature Medicine. 29:1243-1252
We characterized the world’s second case with ascertained extreme resilience to autosomal dominant Alzheimer’s disease (ADAD). Side-by-side comparisons of this male case and the previously reported female case with ADAD homozygote for the APOE3 C
Autor:
Dorothee Schoemaker, Yesica Zuluaga, Lina Marcela Velilla-Jiménez, Joseph F. Arboleda-Velasquez, Francisco Lopera, Hei Torrico-Teave, Carolina Ospina-Villegas, Yakeel T. Quiroz, Heidi I.L. Jacobs
Publikováno v:
Brain Connect
Brain connectivity, 12(1), 52-60. Mary Ann Liebert Inc.
Brain connectivity, 12(1), 52-60. Mary Ann Liebert Inc.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by leukoencephalopathy leading to cognitive impairment. Subtle cognitive deficits can be observed early in the course of