Crosstalk between ILC2s and Th2 cells varies among mouse models

Autor: Rama K. Gurram, Danping Wei, Qiao Yu, Matthew J. Butcher, Xi Chen, Kairong Cui, Gangqing Hu, Mingzhu Zheng, Xiaoliang Zhu, Jangsuk Oh, Bing Sun, Joseph F. Urban, Jr., Keji Zhao, Warren J. Leonard, Jinfang Zhu

Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112073- (2023)

Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are s

Externí odkaz: https://doaj.org/article/ce97580fbbb1471a8ada47a0cdde3d23

Correlation between circulating innate lymphoid cell precursors and thymic function

Autor: Sandra Bajana, Aneta Pankow, Kaili Liu, Martyna Michniowska, Joseph F. Urban, Jr., Wei R. Chen, Xiao-Hong Sun

Publikováno v: iScience, Vol 25, Iss 2, Pp 103732- (2022)

Summary: The thymus has a high capacity to support the differentiation of ILCs, especially when E protein transcription factors are ablated. Whether it contributes to the homeostasis of ILC pools in tissues is not clear. Single-cell RNA sequencing an

Externí odkaz: https://doaj.org/article/0414fadd06084eb9acc6f402538cbbdd

Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure

Autor: Yan Hu, Thanh-Thanh Nguyen, Alice.C.Y. Lee, Joseph F. Urban, Jr., Melanie M. Miller, Bin Zhan, David J. Koch, Jason B. Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D. Bowman, Gary R. Ostroff, Raffi V. Aroian

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 287-294 (2018)

Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women an

Externí odkaz: https://doaj.org/article/936be991753647bb9c3952391d2ad5cf

Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research

Autor: Janis C. Weeks, William M. Roberts, Kristin J. Robinson, Melissa Keaney, Jon J. Vermeire, Joseph F. Urban Jr., Shawn R. Lockery, John M. Hawdon

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 314-328 (2016)

The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device (‘chip’) that r

Externí odkaz: https://doaj.org/article/9f476598198d4afa81ee0b1d6df29faa

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice.

Autor: Desai P; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA., Karl CE; Department of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA., Ying B; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA., Liang CY; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA., Garcia-Salum T; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Santana AC; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Ten-Caten F; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Joseph F Urban Jr; US Department of Agriculture, Agricultural Research Services, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, and Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705, USA., Elbashir SM; Moderna Inc., Cambridge, MA 02142, USA., Edwards DK; Moderna Inc., Cambridge, MA 02142, USA., Ribeiro SP; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Thackray LB; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA., Sekaly RP; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA., Diamond MS; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Aug 21; Vol. 16 (761), pp. eado1941. Date of Electronic Publication: 2024 Aug 21.