Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Joseph F Urban"'
Autor:
Douglas P Jasmer, Bruce A Rosa, Rahul Tyagi, Christina A Bulman, Brenda Beerntsen, Joseph F Urban, Judy Sakanari, Makedonka Mitreva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0007942 (2020)
Efforts to identify new drugs for therapeutic and preventive treatments against parasitic nematodes have gained increasing interest with expanding pathogen omics databases and drug databases from which new anthelmintic compounds might be identified.
Externí odkaz:
https://doaj.org/article/333b6dc197914f47b2c753a9dd44b1bc
Autor:
Julia Esser-von Bieren, Beatrice Volpe, Duncan B Sutherland, Jérôme Bürgi, J Sjef Verbeek, Benjamin J Marsland, Joseph F Urban, Nicola L Harris
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004778 (2015)
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 res
Externí odkaz:
https://doaj.org/article/7539c76447d945d7ad5a940984472d12
Autor:
Luigi Notari, Diana C Riera, Rex Sun, Jennifer A Bohl, Leon P McLean, Kathleen B Madden, Nico van Rooijen, Tim Vanuytsel, Joseph F Urban, Aiping Zhao, Terez Shea-Donohue
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84763 (2014)
Parasitic enteric nematodes induce a type 2 immune response characterized by increased production of Th2 cytokines, IL-4 and IL-13, and recruitment of alternatively activated macrophages (M2) to the site of infection. Nematode infection is associated
Externí odkaz:
https://doaj.org/article/70764d8679d44ee0b250739042ca423c
Autor:
Yan Hu, Brian L Ellis, Ying Y Yiu, Melanie M Miller, Joseph F Urban, Linda Z Shi, Raffi V Aroian
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70702 (2013)
Soil-transmitted helminths are parasitic nematodes that inhabit the human intestine. These parasites, which include two hookworm species, Ancylostomaduodenale and Necator americanus, the whipworm Trichuristrichiura, and the large roundworm Ascarislum
Externí odkaz:
https://doaj.org/article/f7da7da7d8f746c6b4a4529babcf96ff
Autor:
Zhonghan Yang, Viktoriya Grinchuk, Joseph F Urban, Jennifer Bohl, Rex Sun, Luigi Notari, Shu Yan, Thirumalai Ramalingam, Achsah D Keegan, Thomas A Wynn, Terez Shea-Donohue, Aiping Zhao
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59441 (2013)
Type 2 immunity is essential for host protection against nematode infection but is detrimental in allergic inflammation or asthma. There is a major research focus on the effector molecules and specific cell types involved in the initiation of type 2
Externí odkaz:
https://doaj.org/article/4901a0ced78f41729be0c6536d026844
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2263 (2013)
Ascaris suum and Ascaris lumbricoides are two closely related geo-helminth parasites that ubiquitously infect pigs and humans, respectively. Ascaris suum infection in pigs is considered a good model for A. lumbricoides infection in humans because of
Externí odkaz:
https://doaj.org/article/87b50503691f4c5b92d681d5407bf288
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35470 (2012)
Helminth infection in pigs serves as an excellent model for the study of the interaction between human malnutrition and parasitic infection and could have important implications in human health. We had observed that pigs infected with Trichuris suis
Externí odkaz:
https://doaj.org/article/f02dde58eded4e92b7bf39c0e908d859
Autor:
John T Pesce, Thirumalai R Ramalingam, Mark S Wilson, Margaret M Mentink-Kane, Robert W Thompson, Allen W Cheever, Joseph F Urban, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000393 (2009)
Retnla (Resistin-like molecule alpha/FIZZ1) is induced during Th2 cytokine immune responses. However, the role of Retnla in Th2-type immunity is unknown. Here, using Retnla(-/-) mice and three distinct helminth models, we show that Retnla functions a
Externí odkaz:
https://doaj.org/article/2421bca13ec8421da25ecd9eb184c829
Autor:
Rama K. Gurram, Danping Wei, Qiao Yu, Matthew J. Butcher, Xi Chen, Kairong Cui, Gangqing Hu, Mingzhu Zheng, Xiaoliang Zhu, Jangsuk Oh, Bing Sun, Joseph F. Urban, Jr., Keji Zhao, Warren J. Leonard, Jinfang Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112073- (2023)
Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are s
Externí odkaz:
https://doaj.org/article/ce97580fbbb1471a8ada47a0cdde3d23
Publikováno v:
Metabolites, Vol 13, Iss 3, p 358 (2023)
Over 33% of Americans are labeled as obese, leading the World Health Organization to designate obesity as a major public health problem. One consequence of obesity is the development of metabolic syndrome, a condition which has been correlated to an
Externí odkaz:
https://doaj.org/article/75c9e6b222e74054ba9c81b4272541eb