Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Joseph F Costello"'
Autor:
Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider a
Externí odkaz:
https://doaj.org/article/4c9ca26f096d46feb278b4dfc8e66f04
Autor:
Kimberly R Blahnik, Lei Dou, Lorigail Echipare, Sushma Iyengar, Henriette O'Geen, Erica Sanchez, Yongjun Zhao, Marco A Marra, Martin Hirst, Joseph F Costello, Ian Korf, Peggy J Farnham
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17121 (2011)
The H3K9me3 histone modification is often found at promoter regions, where it functions to repress transcription. However, we have previously shown that 3' exons of zinc finger genes (ZNFs) are marked by high levels of H3K9me3. We have now further in
Externí odkaz:
https://doaj.org/article/bc6ab42b82fb4774b11be5e4eb7057e1
Publikováno v:
PLoS Medicine, Vol 3, Iss 12, p e479 (2006)
Externí odkaz:
https://doaj.org/article/c2f929239efe4615a53d8b2d68db5c15
Autor:
Noriaki Minami, Donghyun Hong, Celine Taglang, Georgios Batsios, Anne Marie Gillespie, Pavithra Viswanath, Nicholas Stevers, Carter J. Barger, Joseph F. Costello, Sabrina M. Ronen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract TERT promoter mutations are a hallmark of glioblastoma (GBM). Accordingly, TERT and GABPB1, a subunit of the upstream mutant TERT promoter transcription factor GABP, are being considered as promising therapeutic targets in GBM. We recently r
Externí odkaz:
https://doaj.org/article/c433abd90f8f40d38f8b6730e44721d1
Autor:
Carter J. Barger, Abigail K. Suwala, Katarzyna M. Soczek, Albert S. Wang, Min Y. Kim, Chibo Hong, Jennifer A. Doudna, Susan M. Chang, Joanna J. Phillips, David A. Solomon, Joseph F. Costello
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
TERT promoter mutations are the most common noncoding alterations in cancers, although some remain to be characterised. Here, the authors identify TERT promoter duplications across seven cancer types that are functionally equivalent to well-known hot
Externí odkaz:
https://doaj.org/article/a11e544533df4a98816dfb5ed7b18481
Autor:
Saket Jain, Jonathan W. Rick, Rushikesh S. Joshi, Angad Beniwal, Jordan Spatz, Sabraj Gill, Alexander Chih-Chieh Chang, Nikita Choudhary, Alan T. Nguyen, Sweta Sudhir, Eric J. Chalif, Jia-Shu Chen, Ankush Chandra, Alexander F. Haddad, Harsh Wadhwa, Sumedh S. Shah, Serah Choi, Josie L. Hayes, Lin Wang, Garima Yagnik, Joseph F. Costello, Aaron Diaz, Dieter Henrik Heiland, Manish K. Aghi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF morphology and single-cell transcriptomic profiles based on their la
Externí odkaz:
https://doaj.org/article/14cced134af940a49b4d6fa72e0c4da9
Autor:
Stephen V. Carney, Kaushik Banerjee, Anzar Mujeeb, Brandon Zhu, Santiago Haase, Maria L. Varela, Padma Kadiyala, Claire E. Tronrud, Ziwen Zhu, Devarshi Mukherji, Preethi Gorla, Yilun Sun, Rebecca Tagett, Felipe J. Núñez, Maowu Luo, Weibo Luo, Mats Ljungman, Yayuan Liu, Ziyun Xia, Anna Schwendeman, Tingting Qin, Maureen A. Sartor, Joseph F. Costello, Daniel P. Cahill, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Clinical Cancer Research. 29:1763-1782
Purpose: Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ae6e6bd650e50ff11d9a3202477c21
https://doi.org/10.1158/1078-0432.ccr-22-1896
https://doi.org/10.1158/1078-0432.ccr-22-1896
Autor:
Calixto-Hope G. Lucas, Emily A. Sloan, Rohit Gupta, Jasper Wu, Drew Pratt, Harish N. Vasudevan, Ajay Ravindranathan, Jairo Barreto, Erik A. Williams, Anny Shai, Nicholas S. Whipple, Carol S. Bruggers, Ossama Maher, Burt Nabors, Michael Rodriguez, David Samuel, Melandee Brown, Jason Carmichael, Rufei Lu, Kanish Mirchia, Daniel V. Sullivan, Melike Pekmezci, Tarik Tihan, Andrew W. Bollen, Arie Perry, Anuradha Banerjee, Sabine Mueller, Nalin Gupta, Shawn L. Hervey-Jumper, Nancy Ann Oberheim Bush, Mariza Daras, Jennie W. Taylor, Nicholas A. Butowski, John de Groot, Jennifer L. Clarke, David R. Raleigh, Joseph F. Costello, Joanna J. Phillips, Alyssa T. Reddy, Susan M. Chang, Mitchel S. Berger, David A. Solomon
Publikováno v:
Acta Neuropathologica. 144:747-765
Gliomas arising in the setting of neurofibromatosis type 1 (NF1) are heterogeneous, occurring from childhood through adulthood, can be histologically low-grade or high-grade, and follow an indolent or aggressive clinical course. Comprehensive profili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9443b332541d26f7f773096d51b660
https://doi.org/10.1007/s00401-022-02478-5
https://doi.org/10.1007/s00401-022-02478-5
Autor:
Georgios Batsios, Céline Taglang, Meryssa Tran, Nicholas Stevers, Carter Barger, Anne Marie Gillespie, Sabrina M. Ronen, Joseph F. Costello, Pavithra Viswanath
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 16
Clin Cancer Res
Radiol Imaging Cancer
Clin Cancer Res
Radiol Imaging Cancer
Purpose: Telomere maintenance is a hallmark of cancer. Most tumors maintain telomere length via reactivation of telomerase reverse transcriptase (TERT) expression. Identifying clinically translatable imaging biomarkers of TERT can enable noninvasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8fa686b7071202c2dff7ce2a09cd40
https://doi.org/10.1158/1078-0432.ccr-21-4418
https://doi.org/10.1158/1078-0432.ccr-21-4418
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Supplementary Figures and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bec136e20960303ccc970834308449
https://doi.org/10.1158/1078-0432.22725171.v1
https://doi.org/10.1158/1078-0432.22725171.v1
