Zobrazeno 1 - 10
of 69 108
pro vyhledávání: '"Joseph F"'
Autor:
Stephanie Langella, Kyra Bonta, Yinghua Chen, Yi Su, Daniel Vasquez, David Aguillon, Natalia Acosta-Baena, Ana Y. Baena, Gloria Garcia-Ospina, Margarita Giraldo-Chica, Victoria Tirado, Claudia Muñoz, Silvia Ríos-Romenets, Claudia Guzman-Martínez, Jeremy J. Pruzin, Valentina Ghisays, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik, Pierre N. Tariot, Eric M. Reiman, Francisco Lopera, Yakeel T. Quiroz
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-9 (2024)
Abstract Background Apolipoprotein E (APOE) genotypes have been suggested to influence cognitive impairment and clinical onset in presenilin-1 (PSEN1) E280A carriers for autosomal dominant Alzheimer’s disease (ADAD). Less is known about their impac
Externí odkaz:
https://doaj.org/article/3234fbf9ef1a4a4bae611ce4cce7ba51
Autor:
Matthew J. O’Neill, Tao Yang, Julie Laudeman, Maria E. Calandranis, M. Lorena Harvey, Joseph F. Solus, Dan M. Roden, Andrew M. Glazer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Interpreting the clinical significance of putative splice-altering variants outside canonical splice sites remains difficult without time-intensive experimental studies. To address this, we introduce Parallel Splice Effect Sequencing (ParSE-
Externí odkaz:
https://doaj.org/article/8f555e7c501b489da69369ad216d2e01
Publikováno v:
Hydrobiology, Vol 3, Iss 3, Pp 263-278 (2024)
Leaf litter is an important input to freshwater systems. Leaves provide carbon, nutrients, and secondary compounds. We examined the effects of tree leaf species on chlorophyll a concentration—a proxy for phytoplankton biomass. We found that an inpu
Externí odkaz:
https://doaj.org/article/139c32afea634e62916fa82bc71ba329
Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type
Autor:
Maisa Pinheiro, Nicolas Wentzensen, Michael Dean, Meredith Yeager, Zigui Chen, Amulya Shastry, Joseph F. Boland, Sara Bass, Laurie Burdett, Thomas Lorey, Sambit Mishra, Philip E. Castle, Mark Schiffman, Robert D. Burk, Bin Zhu, Lisa Mirabello
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Invasive cervical cancers (ICC), caused by HPV infections, have a heterogeneous molecular landscape. We investigate the detection, timing, and HPV type specificity of somatic mutations in 3929 HPV-positive exfoliated cervical cell samples fr
Externí odkaz:
https://doaj.org/article/c1bcd6c690174c39b5a8206f244b5eba
Autor:
Philip J. Mease, Joseph F. Merola, Yoshiya Tanaka, Laure Gossec, Iain B. McInnes, Christopher T. Ritchlin, Robert B. M. Landewé, Akihiko Asahina, Barbara Ink, Andrea Heinrichs, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Laura C. Coates
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 5, Pp 1363-1382 (2024)
Abstract Introduction Psoriatic arthritis (PsA) is a chronic inflammatory disease requiring long-term treatment. Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, has demonstrated tolerabili
Externí odkaz:
https://doaj.org/article/4bbb5fc59b154e17b4cb6d05b6603d8e
Autor:
Devlina Chakravarty, Joseph W. Schafer, Ethan A. Chen, Joseph F. Thole, Leslie A. Ronish, Myeongsang Lee, Lauren L. Porter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Recent work suggests that AlphaFold (AF)–a deep learning-based model that can accurately infer protein structure from sequence–may discern important features of folded protein energy landscapes, defined by the diversity and frequency of
Externí odkaz:
https://doaj.org/article/7b3f673b8890490baeb8156a9bc56344
Autor:
Joseph F. Welch, Gordon S. Mitchell
Publikováno v:
Experimental Physiology, Vol 109, Iss 8, Pp 1217-1237 (2024)
Abstract During mild or moderate exercise, alveolar ventilation increases in direct proportion to metabolic rate, regulating arterial CO2 pressure near resting levels. Mechanisms giving rise to the hyperpnoea of exercise are unsettled despite over a
Externí odkaz:
https://doaj.org/article/4e67b7cf7bf2479883329d87907c958f
Autor:
Jennifer Soung, Vivian Laquer, Joseph F. Merola, Angela Moore, Hany Elmaraghy, Chaoran Hu, Maria Lucia Buziqui Piruzeli, Evangeline Pierce, Esther Garcia Gil, Abel D. Jarell
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 8, Pp 2181-2193 (2024)
Abstract Introduction Lebrikizumab, a high-affinity IgG4 monoclonal antibody that selectively inhibits interleukin-13 with high binding affinity and slow dissociation rate, prevents the formation of the interleukin-4Rα/interleukin-13Rα1 heterodimer
Externí odkaz:
https://doaj.org/article/19f34decb7ff4f5fb3bab2dce88b368d
Autor:
Bart J.J. Velders, MD, Michiel D. Vriesendorp, MD, PhD, Federico M. Asch, MD, Michael J. Reardon, MD, Francois Dagenais, MD, Michael G. Moront, MD, Joseph F. Sabik III, MD, Rolf H.H. Groenwold, MD, PhD, Robert J.M. Klautz, MD, PhD
Publikováno v:
JTCVS Open, Vol 19, Iss , Pp 68-90 (2024)
Objective: New echocardiographic definitions have been proposed for hemodynamic structural valve deterioration. We aimed to study their consistency in classifying structural valve deterioration after surgical aortic valve replacement. Methods: Data w
Externí odkaz:
https://doaj.org/article/648e8c282c5d4440984617aebf6ff796
Autor:
Joseph F. Pilat
Publikováno v:
Journal for Peace and Nuclear Disarmament, Pp 1-6 (2024)
Transparency can increase confidence in irreversibility in nuclear disarmament by enhancing verification and increasing the openness of fuel cycle choices and operations. This paper raises key verification challenges and describes how they can be add
Externí odkaz:
https://doaj.org/article/1c3e32b825884cd9960d65f5f9ccc461