Výsledky vyhledávání - "Joseph E. LoSardo"

Ras-dependent maturation of Xenopus oocytes is blocked by modified peptides of GTPase activating protein (GAP)

Autor: Edgar P. Heimer, J. E. Scheffler, Anthony Neri, Joseph E. LoSardo, Eva Bekesi, Kathleen Prinzo

Publikováno v: International Journal of Peptide and Protein Research. 45:194-199

Guanosine triphosphatase activating protein (GAP) is an important modulator of p21ras (Ras)-dependent signal transduction in mammalian cells and in insulin-induced maturation of Xenopus oocytes. A synthetic octapeptide from the catalytic domain of GA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3274cddc195980a486afe01e9502d40
https://doi.org/10.1111/j.1399-3011.1995.tb01040.x

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Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene

Autor: Joseph E. LoSardo, Barry Goggin, Oksana Bohoslawec, Anthony Neri

Publikováno v: Clinical & Experimental Metastasis. 13:236-248

A conditional expression system was established whereby the human K-ras, v-src, and v-mos genes were cloned into a conditional expression vector downstream of the dexamethasone-inducible mouse mammary tumor virus long terminal repeat. Rat-1 fibroblas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceb2663cb23508ec50b5e936bd695c5
https://doi.org/10.1007/bf00133479

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Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP

Autor: Kathleen Prinzo, Joseph E. LoSardo, B. Wegrzynski, S.E. Kiefer, S. D. Emerson, J. E. Scheffler, Kwei-Lan Tsao, Anthony Neri, Eva Bekesi, David S. Waugh

Publikováno v: Journal of Biological Chemistry. 269:22340-22346

Four overlapping peptide fragments of human c-Raf-1 (residues 55-132, 55-117, 77-132, and 77-117) were expressed in Escherichia coli as carboxyl-terminal extensions of maltose binding protein (MBP). The MBP-Raf fusions were purified by affinity chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87f1edc085e5dede0d57155fe12d76b1
https://doi.org/10.1016/s0021-9258(17)31795-7

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Identification of a mammalian nuclear factor and human cDNA-encoded proteins that recognize DNA containing apurinic sites

Autor: Joseph E. Losardo, Paul W. Doetsch, Jack Lenz, Sharon A. Okenquist, Krista K. Hamilton

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 87(9)

Damage to DNA can have lethal or mutagenic consequences for cells unless it is detected and repaired by cellular proteins. Repair depends on the ability of cellular factors to distinguish the damaged sites. Electrophoretic binding assays were used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdf40132cf4f758f150db6d7cd6a356
https://pubmed.ncbi.nlm.nih.gov/2185469

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