Mondo: Unifying diseases for the world, by the world

Autor: Nicole A Vasilevsky, Nicolas A Matentzoglu, Sabrina Toro, Joseph E Flack, Harshad Hegde, Deepak R Unni, Gioconda F Alyea, Joanna S Amberger, Larry Babb, James P Balhoff, Taylor I Bingaman, Gully A Burns, Orion J Buske, Tiffany J Callahan, Leigh C Carmody, Paula Carrio Cordo, Lauren E Chan, George S Chang, Sean L Christiaens, Michel Dumontier, Laura E Failla, May J Flowers, H. Alpha Garrett, Jennifer L Goldstein, Dylan Gration, Tudor Groza, Marc Hanauer, Nomi L Harris, Jason A Hilton, Daniel S Himmelstein, Charles Tapley Hoyt, Megan S Kane, Sebastian Köhler, David Lagorce, Abbe Lai, Martin Larralde, Antonia Lock, Irene López Santiago, Donna R Maglott, Adriana J Malheiro, Birgit H M Meldal, Monica C Munoz-Torres, Tristan H Nelson, Frank W Nicholas, David Ochoa, Daniel P Olson, Tudor I Oprea, David Osumi-Sutherland, Helen Parkinson, Zoë May Pendlington, Ana Rath, Heidi L Rehm, Lyubov Remennik, Erin R Riggs, Paola Roncaglia, Justyne E Ross, Marion F Shadbolt, Kent A Shefchek, Morgan N Similuk, Nicholas Sioutos, Damian Smedley, Rachel Sparks, Ray Stefancsik, Ralf Stephan, Andrea L Storm, Doron Stupp, Gregory S Stupp, Jagadish Chandrabose Sundaramurthi, Imke Tammen, Darin Tay, Courtney L Thaxton, Eloise Valasek, Jordi Valls-Margarit, Alex H Wagner, Danielle Welter, Patricia L Whetzel, Lori L Whiteman, Valerie Wood, Colleen H Xu, Andreas Zankl, Xingmin Aaron Zhang, Christopher G Chute, Peter N Robinson, Christopher J Mungall, Ada Hamosh, Melissa A Haendel

There are thousands of distinct disease entities and concepts, each of which are known by different and sometimes contradictory names. The lack of a unified system for managing these entities poses a major challenge for both machines and humans that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb95e9f275c4c5ac6590aa22f6896dbb
https://doi.org/10.1101/2022.04.13.22273750

Myocardial infarction in non-dissecting aortic root aneurysm

Autor: Joseph E. Flack, Yvonne A. Alameddine, Victor K. Alimov, Richard J. Hicks, Abdallah K. Alameddine

Publikováno v: World Journal of Cardiovascular Diseases. :257-260

We describe a case of a 49-year-old man who presented with an uncomplicted aortic root aneurysm, aortic insufficiency, and ST-elevation myocardial infarction (STEMI) without obstructive coronary artery disease on angiography. The computed tomo- graph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bfa9261a4ea18a12cb581af32528007
https://doi.org/10.4236/wjcd.2013.32040

Risk of dysphagia after transesophageal echocardiography during cardiac operations

Autor: David W. Deaton, John A. Rousou, Howard Krasner, Dennis A. Tighe, Jane Garb, Joseph E. Flack, Richard M. Engelman

Publikováno v: The Annals of Thoracic Surgery. 69:486-489

Dysphagia can be a significant complication following cardiac operations. This study evaluates its incidence and relationship to intraoperative transesophageal echocardiography (TEE) for specific indications versus known factors such as stroke or pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3ee57735c8d77ced077db56d2fb34e
https://doi.org/10.1016/s0003-4975(99)01086-3

Influence of the preoperative signal-averaged electrocardiogram on left ventricular function after coronary artery bypass graft surgery in patients with left ventricular dysfunction

Autor: James R. Cook, Joseph E. Flack, Cheryl A. Gregory, David W. Deaton, John A. Rousou, Richard M. Engelman

Publikováno v: The American Journal of Cardiology. 82:285-289

Patients with ischemic left ventricular (LV) dysfunction often have an improved survival and life quality after coronary artery bypass grafting (CABG), in part due to an improvement in LV function. A lack of LV ejection fraction (EF) improvement post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcfc76a62cc48f76068ac3c37a3c8f7f
https://doi.org/10.1016/s0002-9149(98)00335-x

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Autor: Dipak K. Das, Joseph E. Flack, Nilanjana Maulik, Richard M. Engelman, John A. Rousou, David W. Deaton, Tetsuya Yoshida

Publikováno v: Molecular and Cellular Biochemistry. 186:139-145

Apoptosis or programmed cell death is a genetically controlled response for cells to commit suicide and is associated with DNA fragmentation or laddering. The common inducers of apoptosis include oxygen free radicals/oxidative stress and Ca2+ which a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cce27f509755cf9cce69ab2727bf27a
https://doi.org/10.1023/a:1006883717174