Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joseph E. Clayton"'
Autor:
Carolyn Marquis, Cindy L. Fonseca, Katelyn A. Queen, Lisa Wood, Sarah E. Vandal, Heidi L. H. Malaby, Joseph E. Clayton, Jason Stumpff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Kinesin motor proteins are critical for maintaining mitotic spindle integrity, which is important for chromosome stability. Here, the authors show that the kinesin motor protein, KIF18A, permits the proliferation of chromosomally unstable cells and k
Externí odkaz:
https://doaj.org/article/155fe186fe17428f9306cda918e23864
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Many neurodegenerative diseases induce high levels of sustained cellular stress and alter a number of cellular processes. To examine how different mutations associated with neurodegenerative disease affect cell stress and signaling, we created live-c
Externí odkaz:
https://doaj.org/article/e1322e664d264c2599b645d397ac6d4f
Autor:
Joseph E. Clayton, Lisa Wood, Carolyn Marquis, Heidi L.H. Malaby, Katelyn A. Queen, Sarah E. Vandal, Cindy L. Fonseca, Jason Stumpff
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells may respond differently than diploid cells to treatments that target mitotic
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Many neurodegenerative diseases induce high levels of sustained cellular stress and alter a number of cellular processes. To examine how different mutations associated with neurodegenerative disease affect cell stress and signaling, we created live-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9736533cf2de817a0b9160c794427c4a
https://doi.org/10.1101/735878
https://doi.org/10.1101/735878
Publikováno v:
Cytoskeleton. 72:131-145
Myosins and tropomyosins represent two cytoskeletal proteins that often work together with actin filaments in contractile and motile cellular processes. While the specialized role of tropomyosin in striated muscle myosin-II regulation is well charact
Autor:
Daniel J Chiu, R. Mako Saito, Barbara Conradt, Laura D Young, Joseph E. Clayton, Nadin Memar, Sarah H. Roy, Eleanor M. Beltz, Jenna Holmen, Travis H Green, Isabella Lubin, David V. Tobin, Yuying Liu
Publikováno v:
G3: Genes|Genomes|Genetics
The development and homeostasis of multicellular animals requires precise coordination of cell division and differentiation. We performed a genome-wide RNA interference screen in Caenorhabditis elegans to reveal the components of a regulatory network
Publikováno v:
Mechanisms of Development. 128:317-326
Much of our understanding of the function and regulation of the Cdc14 family of dual-specificity phosphatases originates from studies in yeasts. In these unicellular organisms Cdc14 is an important regulator of M-phase events. In contrast, the Caenor
Autor:
Vladimir Sirotkin, Joseph E. Clayton, Michael L. James, Matthew Lord, Thomas E. Sladewski, Matthew R. Sammons
Publikováno v:
Journal of Cell Science. 124:2466-2477
Fission yeast myosin-I (Myo1p) not only associates with calmodulin, but also employs a second light chain called Cam2p. cam2Δ cells exhibit defects in cell polarity and growth consistent with a loss of Myo1p function. Loss of Cam2p leads to a reduct
Publikováno v:
Cytoskeleton (Hoboken, N.J.). 72(3)
Myosins and tropomyosins represent two cytoskeletal proteins that often work together with actin filaments in contractile and motile cellular processes. While the specialized role of tropomyosin in striated muscle myosin-II regulation is well charact
Autor:
Matthew Lord, Alex R. Hodges, Kathleen M. Trybus, Luther W. Pollard, Joseph E. Clayton, Maria Sckolnick, Carol S. Bookwalter
Publikováno v:
Molecular biology of the cell. 25(1)
A hallmark of class-V myosins is their processivity—the ability to take multiple steps along actin filaments without dissociating. Our previous work suggested, however, that the fission yeast myosin-V (Myo52p) is a nonprocessive motor whose activit