Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Joseph E. Baggott"'
Autor:
Joseph E. Baggott, Sarah L. Morgan
Publikováno v:
Medical Hypotheses. 122:10-15
Methotrexate (MTX), an antifolate, is the anchor drug for the treatment of rheumatoid arthritis (RA). It is inexpensive, effective, and generally safe. When clinical response is inadequate, biological therapies are commonly used in combination with M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54510291b4ff911ff6d187acdda877cc
https://doi.org/10.1016/j.mehy.2018.10.002
https://doi.org/10.1016/j.mehy.2018.10.002
Autor:
Tsunenobu Tamura, Joseph E. Baggott
Publikováno v:
Advances in Nutrition. 6:564-571
Purine nucleotide biosynthesis de novo (PNB) requires 2 folate-dependent transformylases—5′-phosphoribosyl-glycinamide (GAR) and 5′-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) transformylases—to introduce carbon 8 (C8) and carbon 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57043d7f3e599403b1a52374802afc7
https://doi.org/10.3945/an.115.008300
https://doi.org/10.3945/an.115.008300
Autor:
Tsunenobu Tamura, Joseph E. Baggott
Publikováno v:
Nutrients, Vol 7, Iss 2, Pp 1108-1118 (2015)
Nutrients
Nutrients
Elevated circulating total homocysteine (tHcy) concentrations (hyperhomocysteinemia) have been regarded as an independent risk factor for cardiovascular disease (CVD). However, several large clinical trials to correct hyperhomocysteinemia using B-vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084f4fc31a3798f9f468b78032034a4a
https://doi.org/10.3390/nu7021108
https://doi.org/10.3390/nu7021108
Autor:
James R. O'Dell, Stella Aslibekyan, Elizabeth E. Brown, Larry W. Moreland, S. L. Bridges, Richard J. Reynolds, David T. Redden, Sarah L. Morgan, Jin Sha, Jeffrey R. Curtis, Joseph E. Baggott, Donna K. Arnett, Ted R. Mikuls
Publikováno v:
The pharmacogenomics journal
Methotrexate (MTX) has emerged as first-line therapy for early moderate-to-severe rheumatoid arthritis (RA), but individual variation in treatment response remains unexplained. We tested the associations between 863 known pharmacogenetic variants and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5fde9ecb30026afcabf9d8f29ae9b3
https://doi.org/10.1038/tpj.2013.11
https://doi.org/10.1038/tpj.2013.11
Publikováno v:
Cancer Epidemiology. 36:78-81
Several reports suggest that folate has a procarcinogenic effect. Folate has a unique role because its coenzymes are needed for de novo purine and thymine nucleotide biosynthesis. Antifolates, such as methotrexate, are used in cancer treatment. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fba3ef05057189f10dd831b5a67607
https://doi.org/10.1016/j.canep.2011.05.003
https://doi.org/10.1016/j.canep.2011.05.003
Autor:
Laura B. Hughes, Sarah L. Morgan, Joseph E. Baggott, Donna K. Arnett, Elizabeth E. Brown, S. Louis Bridges, Maria I. Danila
Publikováno v:
Current Rheumatology Reports. 12:342-347
Methotrexate (MTX) is one of the most commonly prescribed and most effective drugs for the treatment of rheumatoid arthritis (RA). Given the partial response of many patients and the side effect profile of the drug, there is considerable interest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8869fb2f628d00e187284f1e3feaaab
https://doi.org/10.1007/s11926-010-0120-3
https://doi.org/10.1007/s11926-010-0120-3
Publikováno v:
Journal of Medicinal Food
This study was designed to determine the safety of a medical food, flavocoxid, a proprietary blend of free-B ring flavonoids and flavans from the root of Scutellaria baicalensis (Chinese skullcap) and the bark of Acacia catechu in the dietary managem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1499d8624babe34dc154c0f90e674567
Publikováno v:
Metabolism. 56:708-715
The 10-formyl moiety of 10-formyltetrahydrofolate is the source of carbons at the positions 8 (C(8)) and 2 (C(2)) of the purine ring, originating from formate and a few amino acids. Uric acid is the final catabolic product of purines. In adult humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66015d71e3408d286a8e66b8a6e2e3c9
https://doi.org/10.1016/j.metabol.2006.12.020
https://doi.org/10.1016/j.metabol.2006.12.020
Autor:
Graciela S. Alarcón, Sarah L. Morgan, H Patel, T. M. Beasley, Laura B. Hughes, Hemant K. Tiwari, S. L. Bridges, Joseph E. Baggott, Kenneth G. Saag, J McNicholl, Larry W. Moreland
Publikováno v:
Annals of the Rheumatic Diseases. 65:1213-1218
Background: The anti-folate drug methotrexate (MTX) is commonly used to treat rheumatoid arthritis. Objective: To determine the allele frequencies of five common coding single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cfce11b8385a03d1ec11b85858a1fb
https://doi.org/10.1136/ard.2005.046797
https://doi.org/10.1136/ard.2005.046797
Autor:
Tsunenobu Tamura, Joseph E. Baggott
Publikováno v:
SpringerPlus
Dear Editor We believed for over a half century that the landmark study by Herbert (1962) of experimental human folate deficiency is the one and only of its kind. However, there is a recent study by Golding (2014) published in SpringerPlus (2014, 3:4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd67433c6cef97c4597a5d4d00ceb7f
https://doi.org/10.1186/2193-1801-3-719
https://doi.org/10.1186/2193-1801-3-719